Basic research for elucidation and control of lymphatic metastasis for pancreatic cancer
| Project/Area Number |
26462067
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
又木 雄弘 鹿児島大学, 医歯学域附属病院, 特任講師 (10444902)
前村 公成 鹿児島大学, 医歯学域医学系, 准教授 (30398292)
新地 洋之 鹿児島大学, 医歯学域医学系, 教授 (60284874)
夏越 祥次 鹿児島大学, 医歯学域医学系, 教授 (70237577)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | リンパ節転移 / リンパ節微小環境 / 上皮間葉移行 / 血行性転移 / 炎症 |
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| Outline of Final Research Achievements |
1. M2-tumor associated macrophages those differentiated to immunosuppression increase lymphangiogenesis and promote lymphatic metastasis in pancreatic cancer.TAM that express folate receptor-β play important roles in invasion and metastasis via angiogenesis in pancreatic cancer.2. Pretreatment serum CA 19-9 and DUPAN-2 levels, and expression of p53 and PDGFR-β in the primary tumor are predictors of hematogenous metastasis; and important factors for determination of therapeutic strategy for pancreatic cancer.3.MicroRNA screening using a next-generation sequencer revealed that FZP36L2 which is regulated by microRNA-375 increase invasive ability of pancreatic cancer cells and promote tumor progression.4. We identify a novel metastasis suppressor gene HMP 19 by genome-wide shRNA screening using non-metastatic pancreatic cancer cell line and revealed the mechanisms of inhibition of progression and invasion.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Relationship between the surgical margin status, prognosis, and recurrence in extrahepatic bile duct cancer patients.2017
Author(s)
Kurahara H, Maemura K, Mataki Y, Sakoda M, Iino S, Kawasaki Y, Mori S, Kijima Y, Ueno S, Shinchi H, Takao S, Natsugoe S.
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Journal Title
Langenbeck's Archives of Surgery
Volume: 402
Issue: 1
Pages: 87-93
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical significance of serum carbohydrate antigen 19.9 and duke pancreatic monoclonal antigen type 2 for the prediction of hematogenous metastases in patients with pancreatic ductal adenocarcinoma2016
Author(s)
Kurahara H, Maemura K, Mataki Y, Sakoda M, Iino S, Arigami T, Mori S, Ueno S, Shinchi H, Takao S, Natsugoe S.
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Journal Title
Pancreatology
Volume: 16
Issue: 6
Pages: 1051-6
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Appropriate treatment strategy for IPMN2016
Author(s)
Kurahara H, Maemura K, Mataki Y, Sakoda M, Iino S, Minami K, Kawasaki Y, Yonemori K, Shinchi H, Natsugoe S.
Organizer
The 20th meeting of the International Association of Pancreatology (IAP)
Place of Presentation
仙台国際センター（宮城県仙台市）
Related Report
Int'l Joint Research
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