Efficacy of neoadjuvant chemoradiotherapy for pancreatic ductal adenocarcinoma

• Project/Area Number: 26462068
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kagoshima University
• Principal Investigator: Shinchi Hiroyuki 鹿児島大学, 医歯学域医学系, 教授 (60284874)
• Co-Investigator(Kenkyū-buntansha): 又木 雄弘 鹿児島大学, 医歯学域附属病院, 特任講師 (10444902) ; 前村 公成 鹿児島大学, 医学部・歯学部附属病院, 助手 (30398292) ; 夏越 祥次 鹿児島大学, 医歯学域医学系, 教授 (70237577) ; 蔵原 弘 鹿児島大学, 医学部・歯学部附属病院, その他 (70464469)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 膵癌 / 化学放射線療法 / 術前治療 / 外科治療 / すい臓がん / 放射線治療 / 化学療法 / 手術

Outline of Final Research Achievements

We have examined the efficacy of neoadjuvant chemoradiotherapy (NACRT) for pancreatic ductal adenocarcinoma (PDAC). This study included 17 patients who underwent upfront surgery, 11 patients with surgical resection after NACRT, and 22 patients w/o resection after NACRT, respectively. The median survival time (MST) of patients with surgical resection after NACRT was significantly better than other groups.

Research Products

• [Journal Article] Relationship between the surgical margin status, prognosis, and recurrence in extrahepatic bile duct cancer patients. (2017)
  • Author(s): Kurahara H, Maemura K, Mataki Y, Sakoda M, Iino S, Kawasaki Y, Mori S, Kijima Y, Ueno S, Shinchi H, Takao S, Natsugoe S.
  • Journal Title: Langenbeck's Archives of Surgery Volume: 402 Issue: 1 Pages: 87-93
  • DOI: 10.1007/s00423-016-1491-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gemcitabine and S-1 Induction Chemotherapy Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancers. (2017)
  • Author(s): Maemura K, Mataki Y, Kurahara H, Kawasaki Y, Iino S, Sakoda M, Uchikado Y, Arigami T, Uenosono Y, Mori S, Ueno S, Shinchi H, Natsugoe S.
  • Journal Title: Anticancer Res. Volume: 37 Pages: 233-237
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of proton beam radiotherapy and hyper-fractionated accelerated chemoradiotherapy for locally advanced pancreatic cancer. (2017)
  • Author(s): Maemura K1, Mataki Y2, Kurahara H2, Kawasaki Y2, Iino S2, Sakoda M2, Ueno S3, Arimura T4, Higashi R5, Yoshiura T5, Shinchi H6, Natsugoe S2.
  • Journal Title: Pancreatology. Volume: 17-5 Issue: 5 Pages: 833-838
  • DOI: 10.1016/j.pan.2017.07.191
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Preoperative biliary drainage-related inflammation is associated with shorter survival in biliary tract cancer patients. (2016)
  • Author(s): Kurahara H, Maemura K, Mataki Y, Sakoda M, Iino S, Kawasaki Y, Arigami T, Uenosono Y, Kijima Y, Shinchi H, Takao S, Natsugoe S.
  • Journal Title: Int J Clin Oncol. Volume: 21 Pages: 934-939
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ｉｍｐａｃｔ ｏｆ ｐ53 ａｎｄ ＰＤＧＦＲ－β expression on metastasis and prognosis of patients with pancreatic cancer (2016)
  • Author(s): Ｈｉｒｏｓｈｉ Ｋｕｒａｈａｒａ
  • Journal Title: Ｗｏｒｌｄ Ｊｏｕｒｎａｌ ｏｆ Ｓｕｒｇｅｒｙ Volume: Ｅｐｕｂ ａｈｅａｄ ｏｆ ｐｒｉｎｔ Issue: 8 Pages: 1977-1984
  • DOI: 10.1007/s00268-016-3477-2
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Clinical significance of serum carbohydrate antigen 19.9 and duke pancreatic monoclonal antigen type 2 for the prediction of hematogenous metastases in patients with pancreatic ductal adenocarcinoma (2016)
  • Author(s): Kurahara H, Maemura K, Mataki Y, Sakoda M, Iino S, Arigami T, Mori S, Ueno S, Shinchi H, Takao S, Natsugoe S.
  • Journal Title: Pancreatology Volume: 16 Issue: 6 Pages: 1051-6
  • DOI: 10.1016/j.pan.2016.09.014
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] CD133 Modulate HIF-1α Expression under Hypoxia in EMT Phenotype Pancreatic Cancer Stem-Like Cells. (2016)
  • Author(s): Maeda K, Ding Q, Yoshimitsu M, Kuwahata T, Miyazaki Y, Tsukasa K, Hayashi T, Shinchi H, Natsugoe S, Takao S.
  • Journal Title: Int J Mol Sci. Volume: 17 Issue: 7 Pages: 1025-1025
  • DOI: 10.3390/ijms17071025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of Maternal Embryonic Leucine Zipper Kinase (MELK) Correlates to Malignant Potentials in Hepatocellular Carcinoma. (2016)
  • Author(s): Hiwatashi K, Ueno S, Sakoda M, Iino S, Minami K, Yonemori K, Nishizono Y, Kurahara H, Mataki Y, Maemura K, Shinchi H, Natsugoe S.
  • Journal Title: Anticancer Res. Volume: 36 Pages: 5183-5188
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Predictors of early stages of histological progression of branch duct IPMN. (2015)
  • Author(s): Kurahara H, Maemura K, Mataki Y, Sakoda M, Iino S, Kijima Y, Ishigami S, Ueno S, Shinchi H, Natsugoe S.
  • Journal Title: Langenbecks Arch Surg. Volume: 400 Issue: 1 Pages: 49-56
  • DOI: 10.1007/s00423-014-1259-6
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Assessment of percutaneous laparoscopic ultrasonography-guided core needle biopsy for the advanced diagnosis of unresectable pancreatic cancer. (2015)
  • Author(s): Maemura K, Shinchi H, Mataki Y, Kurahara H, Iino S, Sakoda M, Ueno S, Takao S, Natsugoe S.
  • Journal Title: JOP. Volume: 16 Pages: 45-49
  • DOI: 10.6092/1590-8577/2891
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Mucin expression in endoscopic ultrasound-guided fine-needle aspiration specimens is a useful prognostic factor in pancreatic ductal adenocarcinoma. (2015)
  • Author(s): Higashi M, Yokoyama S, Yamamoto T, Goto Y, Kitazono I, Hiraki T, et al.
  • Journal Title: Pancreas Volume: 44 Issue: 5 Pages: 728-34
  • DOI: 10.1097/mpa.0000000000000362
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Pancreaticogastrostomy after Pancreaticoduodenectomy Using Twin Square Wrapping with Duct-to-Mucosa Anastomosis. (2015)
  • Author(s): ２．Maemura K, Mataki Y, Kurahara H, Mori S, Higo N, Sakoda M, Iino S, Nakajo A, Ishigami S, Ueno S, Takao S, Shinchi H, Natsugoe S.
  • Journal Title: Eur Surg Res Volume: 55 Issue: 1-2 Pages: 109-118
  • DOI: 10.1159/000433425
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostication by inflammation-based score in patients with locally advanced pancreatic cancer treated with chemoradiotherapy (2015)
  • Author(s): Hiroshi Kurahara
  • Journal Title: Pancreatology Volume: 15 Issue: 6 Pages: 688-693
  • DOI: 10.1016/j.pan.2015.09.015
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 教室にて術前化学療法を行った切除可能膵癌の検討 (2014)
  • Author(s): 又木 雄弘, 新地 洋之, 前村 公成, 蔵原 弘, 川崎 洋太, 出先 亮介, 上野 真一, 迫田 雅彦, 飯野 聡, 高尾 尊身, 夏越 祥次
  • Journal Title: 胆膵の病態生理 Volume: 30 Pages: 25-29
  • NAID: 40020125468
  • Peer Reviewed
• [Journal Article] 傍大動脈リンパ節転移を伴うcStage IVb膵癌に対してS-1+gemcitabine療法により組織学的CRが得られた1例 (2014)
  • Author(s): 蔵原 弘, 前村 公成, 又木 雄弘, 迫田 雅彦, 飯野 聡, 樋渡 清司, 南 幸次, 石神 純也, 上野 真一, 新地 洋之, 夏越 祥次
  • Journal Title: 膵臓 Volume: 29 Pages: 898-904
  • NAID: 130004873950
  • Peer Reviewed
• [Journal Article] Clinical impact of intraoperative navigation using a Doppler ultrasonographic guided vessel tracking technique for pancreaticoduodenectomy. (2014)
  • Author(s): 1.Maemura K, Mataki Y, Kurahara H, Iino S, Sakoda M, Ueno S, Shinchi H, Takao S, Natsugoe S
  • Journal Title: Int Surg Volume: 99 Issue: 6 Pages: 770-778
  • DOI: 10.9738/intsurg-d-14-00060.1
  • Peer Reviewed / Open Access
• [Journal Article] Contrast-enhanced CT and diffusion-weighted MR imaging: Performance as a prognostic factor in patients with pancreatic ductal adenocarcinoma (2014)
  • Author(s): Fukukura, Y. Takumi, K. Higashi, M. Shinchi, H. Kamimura, K. Yoneyama, T. Tateyama, A.
  • Journal Title: Eur J Radiol Volume: 83 Issue: 4 Pages: 612-619
  • DOI: 10.1016/j.ejrad.2013.12.016
  • Peer Reviewed / Open Access
• [Journal Article] Hypoxia inducible factor-1 alpha plays a pivotal role in hepatic metastasis of pancreatic cancer: an immunohistochemical study. (2014)
  • Author(s): Matsuo Y, Ding Q, Desaki R, Maemura K, Mataki Y, Shinchi H, Natsugoe S, Takao S.
  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 21 Issue: 2 Pages: 105-112
  • DOI: 10.1002/jhbp.6
  • Peer Reviewed / Open Access
• [Presentation] 膵断端の完全被覆化による膵瘻防止を目指した水平マット レス式膵胃吻合法-Twin square wrapping 法 (2017)
  • Author(s): 前村公成、又木雄弘、蔵原弘、川崎洋太、橋口真征、飯野聡、迫 田雅彦、上野真一、新地洋之、夏越祥次
  • Organizer: 第 72 回日本消化器外科学会総会
• [Presentation] 教室で Conversion surgery を施行しえた切除不能膵癌の 検討 (2017)
  • Author(s): 又木雄弘、前村公成、蔵原弘、川﨑洋太、橋口真征、迫田雅彦、 飯野聡、上野真一、新地洋之、夏越祥次
  • Organizer: 第 72 回日本消化器外科学会総会
• [Presentation] 切除可能膵癌に対する予後改善を目指した治療戦略 (2017)
  • Author(s): 蔵原弘、前村公成、又木雄弘、迫田雅彦、飯野聡、川崎洋太、橋 口真征、上野真一、新地洋之、夏越祥次
  • Organizer: 第 72 回日本消化器外科学会総会
• [Presentation] 局所進行切除不能膵癌におけるS-1併用化学放射線療法前のゲムシタビン＋S-1導入化学療法の効果、 (2016)
  • Author(s): 前村公成、又木雄弘、蔵原弘、川崎洋太、南幸次、米盛圭一、飯野聡、迫田雅彦、上野真一、高尾尊身、新地洋之、夏越祥次
  • Organizer: 第54回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-20
• [Presentation] Clinical impact of Gemcitabine with S-1 and chemoradiation concomitant S-1 for locally advanced unresectable pancreatic cancer、 (2016)
  • Author(s): 前村公成、又木雄弘、蔵原弘、川崎洋太、迫田雅彦、飯野聡、樋渡清司、上野真一、高尾尊身、新地洋之、夏越祥次
  • Organizer: 第47回日本膵臓学会大会
  • Place of Presentation: 仙台国際会議場（宮城県仙台市）
  • Year and Date: 2016-08-04
• [Presentation] Doppler超音波による術中リアルタイム血流追跡法の膵頭十二指腸切除術に対する効果 (2016)
  • Author(s): 前村公成、又木雄弘、蔵原弘、川崎洋太、南幸次、米盛圭一、迫田雅彦、飯野聡、上野真一、高尾尊身、新地洋之、夏越祥次
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2016-04-16
• [Presentation] 局所進行切除不能膵癌に対するTS-1併用化学放射線療法 vs TS-1単独化学療法． (2015)
  • Author(s): 新地洋之，前村公成，又木雄弘，蔵原 弘，高尾尊身，夏越祥次
  • Organizer: 第46回日本膵臓学会大会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-06-19
• [Presentation] 切除可能および境界膵癌に対する術前化学（放射線）療法の意義． (2015)
  • Author(s): 新地洋之，前村公成，又木雄弘，蔵原 弘，樋渡清司，飯野 聡，迫田雅彦，上野真一，高尾尊身，夏越祥次
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-04-17
• [Presentation] Oral S-1 with concurrent radiotherapy versus S-1 alone in patients with locally unresectable pancreatic cancer. (2014)
  • Author(s): Shinchi H, Takao S, Maemura K, Mataki Y, Kurahara H, Hiwatashi K, Ino S, Sakoda M, Ueno S, Natsugoe S
  • Organizer: American Pancreatic Association (45th Anniversary meeting)
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2014-11-08
• [Presentation] 進行膵癌に対するTS-1併用化学放射線療法 vs TS-1単独化学療法のランダム化比較試験． (2014)
  • Author(s): 新地洋之，前村公成，又木雄弘，蔵原 弘，樋渡清司，飯野 聡，迫田雅彦，上野真一，高尾尊身，夏越祥次
  • Organizer: 第52回日本癌治療学会
  • Place of Presentation: 横浜市，パシフィコ横浜
  • Year and Date: 2014-08-29
• [Presentation] 臨床試験に基づいた進行膵癌に対するTS-1併用化学放射線療法の有用性． (2014)
  • Author(s): 新地洋之，前村公成，又木雄弘，蔵原 弘，樋渡清司，飯野 聡，迫田雅彦，上野真一，高尾尊身，夏越祥次
  • Organizer: 第26回日本肝胆膵外科学会
  • Place of Presentation: 和歌山市，和歌山県民文化会館
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] 局所進行膵癌に対する新しい治療法としてのTS-1併用化学放射線治療の有効性． (2014)
  • Author(s): 新地洋之，前村公成，又木雄弘，蔵原 弘，樋渡清司，飯野 聡，迫田雅彦，上野真一，高尾尊身，夏越祥次
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 京都市国際会議場
  • Year and Date: 2014-04-03
• [Book] 胆と膵 (2016)
  • Author(s): 新地洋之， 前村公成，又木雄弘，蔵原 弘，川崎洋太，南 幸次，飯野 聡，迫田雅彦，上野真一，高尾尊身，夏越祥次
  • Publisher: 医学図書出版
• [Book] 日本臨床 (2015)
  • Author(s): 新地洋之， 前村公成，又木雄弘，蔵原 弘，高尾尊身，夏越祥次
  • Total Pages: 7
  • Publisher: 日本臨床社
• [Book] 切除可能および境界膵癌に対する術前化学（放射線）療法の試み．膵癌治療up-to-date (2014)
  • Author(s): 新地洋之，又木雄弘，前村公成，蔵原 弘，迫田雅彦，飯野 聡，樋渡清司，上野真一，高尾尊身，夏越祥次
  • Total Pages: 6
  • Publisher: 医学図書出版（株）
• [Funded Workshop] Society of American Gastrointestinal and Endoscopic Surgeons (2016)
  • Place of Presentation: Boston,USA
  • Year and Date: 2016-03-16