| Project/Area Number |
26462072
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Kawai Manabu 和歌山県立医科大学, 医学部, 准教授 (40398459)
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| Co-Investigator(Kenkyū-buntansha) |
清水 敦史 和歌山県立医科大学, 医学部, 学内助教 (00637910)
山上 裕機 和歌山県立医科大学, 医学部, 教授 (20191190)
岡田 健一 和歌山県立医科大学, 医学部, 講師 (50407988)
谷 眞至 和歌山県立医科大学, 医学部, 准教授 (60236677)
廣野 誠子 和歌山県立医科大学, 医学部, 講師 (60468288)
宮澤 基樹 和歌山県立医科大学, 医学部, 助教 (90549734)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 膵頭十二指腸切除術 / 術後合併症 / 胆汁 / サイトカイン / 網羅的解析 / 胆道ドレナージ / 胆汁中サイトカイン / 胆管ドレナージ / 膵切除 / 膵切除後合併症 / 診断法 |
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| Outline of Final Research Achievements |
The aim is to evaluate the impact of cytokine to predict intra-abdominal abscess after pancreaticoduodenectomy by analysis of cytokine in bile. Cytokine including IL-1α、IL-1β、IL-4、IL-6、IL-8、IL-10、IL-13、MCP-1、IFN-γ、TNF-α in bile which was collected intraoperatively were measured by global analysis. Levels of IL-1α、IL-1β、IL-4、and TNF-α in bile of patients with intra-abdominal abscess after pancreaticoduodenectomy were significantly higher than those of patients without intra-abdominal abscess. Furthermore studies should be required to detect cut-off levels of IL-1α、IL-1β、IL-4、and TNF-α in bile to predict the risk of intra-abdominal abscess after pancreaticoduodenectomy.
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