Identification of PKM as a target for pancreatic cancer therapy
| Project/Area Number |
26462077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
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Principal Investigator |
Yamamoto Kuniharu 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員 (00375073)
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 賢一 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (10282055)
田沼 延公 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵癌 / ピルビン酸キナーゼ / 癌代謝 |
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| Outline of Final Research Achievements |
The aim of this study is to evaluate the role of PKM2 in the development of pacreatic cancer. We will identify PKM2 as a good target for anti-pancreatic cancer therapy. We analyzed the molecular mechanisms of PKM2 using pancreatic cancer tissue and pancreatic cancer cell lines. As a result, we demonstrated that PKM2 promotes panceratic cancer cell growth through Warburg effect.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Enhanced expression of PKM2 is involved in the gastric cancer development via regulating cancer specific metabolism.2017
Author(s)
Shiroki T, Yokoyama M, Tanuma N, Maejima R, Tamai K, Yamaguchi K, Oikawa T, Noguchi T, Miura K, Fujiya T, Shima H, Sato I, Kamiya N, Hatakeyama M, Iijima K, Shimosegawa T and Satoh K.
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Journal Title
Cancer Science
Volume: 印刷中
Issue: 5
Pages: 931-940
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] ピルビン酸キナーゼM2(PKM2)と膵癌細胞増殖第2016
Author(s)
1)横山 美沙, 渋谷 莉恵, 坂本 良美, 田沼 延公, 望月 麻衣, 中村 真央, 玉井 恵一, 山口 壹範, 田中 伸幸, 菅村 和夫, 佐藤 賢一
Organizer
日本膵臓学会大会
Place of Presentation
仙台
Year and Date
2016-08-04
Related Report
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