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Identification of PKM as a target for pancreatic cancer therapy

Research Project

Project/Area Number 26462077
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionMiyagi Prefectural Hospital Organization Miyagi Cancer Center

Principal Investigator

Yamamoto Kuniharu  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員 (00375073)

Co-Investigator(Kenkyū-buntansha) 佐藤 賢一  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (10282055)
田沼 延公  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords膵癌 / ピルビン酸キナーゼ / 癌代謝
Outline of Final Research Achievements

The aim of this study is to evaluate the role of PKM2 in the development of pacreatic cancer. We will identify PKM2 as a good target for anti-pancreatic cancer therapy. We analyzed the molecular mechanisms of PKM2 using pancreatic cancer tissue and pancreatic cancer cell lines. As a result, we demonstrated that PKM2 promotes panceratic cancer cell growth through Warburg effect.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results)

  • [Journal Article] Enhanced expression of PKM2 is involved in the gastric cancer development via regulating cancer specific metabolism.2017

    • Author(s)
      Shiroki T, Yokoyama M, Tanuma N, Maejima R, Tamai K, Yamaguchi K, Oikawa T, Noguchi T, Miura K, Fujiya T, Shima H, Sato I, Kamiya N, Hatakeyama M, Iijima K, Shimosegawa T and Satoh K.
    • Journal Title

      Cancer Science

      Volume: 印刷中 Issue: 5 Pages: 931-940

    • DOI

      10.1111/cas.13211

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ピルビン酸キナーゼM2(PKM2)と膵癌細胞増殖2016

    • Author(s)
      1)横山 美沙, 渋谷 莉恵, 坂本 良美, 田沼 延公, 玉井 恵一, 田中 伸幸, 山口 壹範, 菅村 和夫, 佐藤 賢一
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ピルビン酸キナーゼM2(PKM2)と膵癌細胞増殖第2016

    • Author(s)
      1)横山 美沙, 渋谷 莉恵, 坂本 良美, 田沼 延公, 望月 麻衣, 中村 真央, 玉井 恵一, 山口 壹範, 田中 伸幸, 菅村 和夫, 佐藤 賢一
    • Organizer
      日本膵臓学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-08-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] ピルビン酸キナーゼM2(PKM2)は膵癌で高発現し、細胞増殖能を亢進させる2014

    • Author(s)
      横山 美沙、白木 健悠、田沼 延公、玉井 恵一、山口 壹範、田中 伸幸、菅村 和夫、佐藤 賢一
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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