Microsimulation of Patients Undergone Aortic Valve Replacement.

• Project/Area Number: 26462085
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Nagoya University
• Principal Investigator: Abe Tomonobu 名古屋大学, 医学部附属病院, 病院講師 (20378037)
• Co-Investigator(Kenkyū-buntansha): 安藤 昌彦 名古屋大学, 医学部附属病院, 准教授 (10322736) ; 碓氷 章彦 名古屋大学, 医学系研究科, 教授 (30283443) ; 大島 英揮 名古屋大学, 医学系研究科, 准教授 (40378188) ; 荒木 善盛 名古屋大学, 医学部附属病院, 病院講師 (70437010)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 人工弁 / 心臓弁膜症 / シミュレーション / メタアナリシス / 機械弁 / 出血 / 塞栓 / 弁膜症 / 長期成績 / 合併症

Outline of Final Research Achievements

A meta-analysis of long term results of mechanical valve replacement was performed. We found that the incidence of valve relatred complication was different from western countries. The rate of bleeding complication was much less in Japan compared to western countries. We also performed microsimulation of deaths and complications following valve replacement using numbers obtained from the meta-analysis and found that best valve choice is very different between western countries and Japan. The paper, Influence of characteristics of Japanese patients on the long-term outcomes after aortic valve replacement: results of a microsimulation. received the best achievement award of Japanese society of thoracic surgery.

Research Products

• [Journal Article] The oral administration of clarithromycin prevents the progression and rupture of aortic aneurysm (2018)
  • Author(s): Uchida W, Narita Y, Yamawaki-Ogata A, Tokuda Y, Mutsuga M1 Lee Fujimoto K, Abe T, Oshima H, Usui A
  • Journal Title: J Vasc Surg Volume: epub Issue: 6 Pages: 82S-92S.e2
  • DOI: 10.1016/j.jvs.2017.12.047
  • Peer Reviewed
• [Journal Article] Coronary Artery Bypass Surgery for the Patient with a History of Anaphylaxis due to Neuromuscular Blocking Agent ; Report of a Case (2018)
  • Author(s): Toyama M, Abe T, Nakayama M, Takahashi T, Shiba T, Nakajima C
  • Journal Title: Kyobu Geka Volume: 71 Pages: 115-119
  • NAID: 40021455913
  • Peer Reviewed
• [Journal Article] Clinical outcomes and quality of life after surgery for dilated ascending aorta at the time of aortic valve replacement; wrapping versus graft replacement (2017)
  • Author(s): Abe T, Terazawa S, Ito H, Tokuda Y, Fujimoto K, Mutsuga M, Narita Y, Oshima H, Usui A
  • Journal Title: Nagoya Journal of Medical Science Volume: 79 Issue: 4 Pages: 443-451
  • DOI: 10.18999/nagjms.79.4.443
  • NAID: 120006365319
  • ISSN: 2186-3326
  • URL: https://nagoya.repo.nii.ac.jp/records/24893
  • Peer Reviewed
• [Journal Article] Entire Circumferential Reconstruction of the Right Atrium Surrounded by Angiosarcoma (2017)
  • Author(s): Hibino M, Abe T, Oshima H, Narita Y, Mutsuga M, Fujimoto KL, Tokuda Y, Yamana K, Kuroda T, Usui A.
  • Journal Title: Ann Thorac Surg Volume: 103 Issue: 6 Pages: 483-485
  • DOI: 10.1016/j.athoracsur.2016.11.032
• [Journal Article] Comparison of the Long-Term Outcomes of Mechanical and Bioprosthetic Aortic Valves ― A Propensity Score Analysis ― (2017)
  • Author(s): Minakata K, Tanaka S, Tamura N, Yanagi S, Ohkawa Y, Okonogi S, Kaneko T, Usui A, Abe T, Shimamoto M, Takahara Y, Yamanaka K, Yaku H, Sakata R.
  • Journal Title: Circulation Journal Volume: 81 Issue: 8 Pages: 1198-1206
  • DOI: 10.1253/circj.CJ-17-0154
  • NAID: 130005859037
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] The efficacy and risk of cerebrospinal fluid drainage for thoracoabdominal aortic aneurysm repair: a retrospective observational comparison between drainage and non-drainage (2017)
  • Author(s): Sugiura J, Oshima H, Abe T, Narita Y, Araki Y, Fujimoto K, Mutsuga M, Usui A.
  • Journal Title: Interact Cardiovasc Thorac Surg Volume: 24（４） Pages: 609-614
  • DOI: 10.1093/icvts/ivw436
  • Peer Reviewed
• [Journal Article] Ultrasound visualization of the left circumflex artery by direct endocardial scanning of the mitral annulus during surgery. (2017)
  • Author(s): Abe T, Uchida W, Narita Y, Usui A.
  • Journal Title: J Thorac Cardiovasc Surg. Volume: 153(4) Issue: 1 Pages: 53-55
  • DOI: 10.1016/j.jtcvs.2016.08.022
  • NAID: 120005981208
  • Peer Reviewed
• [Journal Article] The cannulation strategy in surgery for acute type A dissection. (2017)
  • Author(s): Abe T, Usui A.
  • Journal Title: Gen Thorac Cardiovasc Surg. Volume: 65(4) Issue: 1 Pages: 1-9
  • DOI: 10.1007/s11748-016-0711-7
  • Peer Reviewed
• [Journal Article] The long-term results and changing patterns of biological valves at the mitral position in contemporary practice in Japan (2016)
  • Author(s): Abe T, Ito H, Mutsuga M, Fujimoto K, Terazawa S, Narita Y, Oshima H, Usui A
  • Journal Title: Nagoya Journal of Medical Science Volume: 78 Issue: 4 Pages: 369-376
  • DOI: 10.18999/nagjms.78.4.369
  • NAID: 120005889974
  • ISSN: 2186-3326
  • URL: https://nagoya.repo.nii.ac.jp/records/22937
  • Peer Reviewed
• [Journal Article] Extended total arch replacement via the L-incision approach: single-stage repair for extensive aneurysms of the aortic arch. (2016)
  • Author(s): Tokuda Y, Oshima H, Narita Y, Abe T, Mutsuga M, Fujimoto K, Terazawa S, Ito H, Hibino M, Uchida W, Komori K, Usui A.
  • Journal Title: Interact Cardiovasc Thorac Surg Volume: 2016 Feb 29
  • Peer Reviewed / Open Access
• [Journal Article] Hybrid versus open repair of aortic arch aneurysms: comparison of postoperative and mid-term outcomes with a propensity score-matching analysis. (2016)
  • Author(s): Tokuda Y, Oshima H, Narita Y, Abe T, Araki Y, Mutsuga M, Fujimoto K, Terazawa S, Yagami K, Ito H, Yamamoto K, Komori K, Usui A.
  • Journal Title: Eur J Cardiothorac Surg Volume: 49(1) Issue: 1 Pages: 149-56
  • DOI: 10.1093/ejcts/ezv063
  • Peer Reviewed / Open Access
• [Journal Article] An Epicardial Mesothelial Cyst Attached to the Ascending Aorta. (2015)
  • Author(s): Suenaga Y, Abe T, Mutsuga M, Araki Y, Usu A.
  • Journal Title: Heart Surg Forum Volume: 18(5) Issue: 5 Pages: 194-5
  • DOI: 10.1532/hsf.1293
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] An L-Shaped Incision for an Extensive Thoracic Aortic Aneurysm and Coronary Artery Bypass Using the Left Internal Thoracic Artery. (2015)
  • Author(s): Abe T, Suenaga H, Oshima H, Araki Y, Mutsuga M, Fujimoto K, Usui A.
  • Journal Title: Aorta (Stamford) Volume: 3(2) Issue: 02 Pages: 86-89
  • DOI: 10.12945/j.aorta.2015.14-061
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Influence of the characteristics of Japanese patients on the long-term outcomes after aortic valve replacement: results of a microsimulation. (2015)
  • Author(s): Abe T, Oshima H, Narita Y, Araki Y, Mutsuga M, Fujimoto K, Tokuda Y, Terazawa S, Yagami K, Usui A.
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 63(5) Issue: 5 Pages: 260-6
  • DOI: 10.1007/s11748-014-0499-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] nfluence of the characteristics of Japanese patients on the long-term outcomes after aortic valve replacement: results of a microsimulation (2014)
  • Author(s): Abe T, Oshima H, Narita Y, Araki Y, Mutsuga M, Fujimoto K, Tokuda Y, Terazawa S, Yagami K, Usui A.
  • Journal Title: Gen Thorac Cardiovasc Sur Volume: e-pub ahead of print Pages: 17-17
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 虚血性僧帽弁閉鎖不全に対する僧帽弁輪形成術と両尖温存弁置換術の長期成績の比較 (2017)
  • Author(s): 阿部 知伸, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 成田 裕司, 大島 英揮, 碓氷 章彦
  • Organizer: 第47回日本心臓血管外科学会
  • Place of Presentation: グランドニッコー東京台場（東京都港区）
  • Year and Date: 2017-02-27
• [Presentation] 僧帽弁手術における、左房内腔からの僧帽弁輪直接エコーによる冠状動脈回旋枝の描出 (2017)
  • Author(s): 阿部 知伸, 内田 亘, 伊藤 英樹, 山名 孝治, 寺澤 幸枝, 徳田 順之, 藤本 和郎, 六鹿 雅登, 成田 裕司, 大島 英揮, 碓氷 章彦
  • Organizer: 日本心臓血管外科学会
• [Presentation] On-X二葉弁の中長期成績 (2017)
  • Author(s): 阿部 知伸, 前田 正信, 加藤 亙, 田嶋 一喜, 宮原 健, 松浦 昭雄, 尾関 貴啓, 伊藤 敏明, 野中 利通, 桜井 一, 萩原 啓明, 江田 匡仁, 成田 裕司, 大島 英揮, 碓氷 章彦
  • Organizer: 日本心臓血管外科学会
• [Presentation] 虚血性僧帽弁閉鎖不全に対する僧帽弁輪形成と両尖温存弁置換術の長期成績の比較 (2017)
  • Author(s): 阿部 知伸, 伊藤 英樹, 山名 孝治, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 成田 裕司, 大島 英揮, 碓氷 章彦
  • Organizer: 日本心臓血管外科学会
• [Presentation] The Safety and Efficacy of the Maze Type Procedure in Reoperative Mitral Valve Surgery (2017)
  • Author(s): T. Abe, Y. Tokuda, K. Fujimoto, M. Mutsuga, Y. Narita, H. Oshima, A. Usui
  • Organizer: AATS Mitral Conclave
  • Int'l Joint Research
• [Presentation] ビッグデータ時代の外科医療 JACVSD/NCDビッグデータの臨床応用への課題 (2017)
  • Author(s): 徳田 順之, 伊藤 英樹, 寺澤 幸枝, 山名 孝治, 六鹿 雅登, 藤本 和朗, 阿部 知伸, 成田 裕司, 大島 英揮, 碓氷 章彦
  • Organizer: 日本外科学会
• [Presentation] 中・長期成績からみた透析患者に対する人工弁選択 機械弁・生体弁による透析患者の弁置換後の長期予後 マイクロシミュレーション (2016)
  • Author(s): 阿部 知伸, 岡田 典隆, 田嶋 一喜, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 成田 裕司, 大島 英揮, 碓氷 章彦
  • Organizer: 第54回日本人工臓器学会大会
  • Place of Presentation: 米子コンベンションセンター（鳥取県米子市）
  • Year and Date: 2016-11-23
• [Presentation] 心房細動を伴う心臓再手術症例においてメイズ手術を併施すべきか (2016)
  • Author(s): 阿部 知伸, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 成田 裕司, 大島 英揮, 碓氷 章彦
  • Organizer: 第69回日本胸部外科学会
  • Place of Presentation: 岡山コンベンションセンター（岡山県岡山市）
  • Year and Date: 2016-09-28
• [Presentation] Management Of Fusiform Aeurysmal Ascending Aorta At The Time Of Aortic Valve Replacement: Aorta Wrapping Versus Graft Replacement; Mid-term Results (2016)
  • Author(s): Tomonobu Abe, Sachie Terazawa, Yoshiyuki Tokuda, Kazuro Fujimoto Masato Mutsuga, Yuji Narita, Hideki Oshima, Akihiko Usui
  • Organizer: American Association for Throacic Surgery, Aortic Symposium 2016
  • Place of Presentation: New York（USA）
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] 一般患者の人工弁選択基準を 血液透析患者にあてはめることは 妥当か？ モデルによる解析 (2016)
  • Author(s): 阿部知伸
  • Organizer: 第４６回日本心臓血管外科学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2016-02-16
• [Presentation] メタアナリシスから見た本邦の機械弁置換術後長期成績の特徴とそれが人工弁選択に与え る影響 (2015)
  • Author(s): 阿部 知伸
  • Organizer: 第５３回日本人工臓器学会大会
  • Place of Presentation: 東京ドームホテル（東京都文京区）
  • Year and Date: 2015-11-20
• [Presentation] Thromboembolic and Bleeding Complications in Patients with Mechanical Heart Valve Prosthesis in Japan A Systematic Review (2015)
  • Author(s): Tomonobu Abe
  • Organizer: ASCVTS 2015
  • Place of Presentation: Hong Kong,CHINA
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] 本邦の大動脈弁置換術後の 弁関連合併症の特徴と それが人工弁選択に与える影響 (2015)
  • Author(s): 阿部知伸、大島英揮、成田裕司、荒木善盛 六鹿雅登、藤本和朗、寺澤幸枝、八神啓、伊藤英樹 碓氷章彦
  • Organizer: 第４５回日本心臓血管外科学会総会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2015-02-16 – 2015-02-18
• [Presentation] Mitral Valve Repair versus Replacement in the Elderly; Long-term Results in Clinical Outcomes and Quality of Life (2014)
  • Author(s): 阿部知伸、大島英揮、成田裕司、荒木善盛 六鹿雅登、藤本和朗、寺澤幸枝、八神啓、伊藤英樹 碓氷章彦
  • Organizer: 第６７回日本胸部外科学会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-09-30 – 2014-10-03
• [Book] 最新人工心肺 (2017)
  • Author(s): 碓氷章彦 上田裕一
  • Total Pages: 292
  • Publisher: 名古屋大学出版