Development of novel elastic biodegradable material for improve cardiac function with regenerating cardiomyocytes post myocardial infarction

• Project/Area Number: 26462086
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Nagoya University
• Principal Investigator: FUJIMOTO KAZURO 名古屋大学, 医学部附属病院, 病院講師 (70644665)
• Co-Investigator(Kenkyū-buntansha): 碓氷 章彦 名古屋大学, 医学系研究科, 教授 (30283443) ; 大島 英揮 名古屋大学, 医学系研究科, 准教授 (40378188) ; 成田 裕司 名古屋大学, 医学部附属病院, 講師 (60378221) ; 緒方 藍歌 名古屋大学, 医学系研究科, 特任助教 (70718311)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 生体吸収材料 / 心臓 / 物理的特性 / 生体材料 / 形状記憶ポリマー / 心筋再生 / 心筋梗塞 / 弾力生体材料 / 再生医療

Outline of Final Research Achievements

We developed the biodegradable material for the preservation of the cardiac function to restrict cardiac remodeling post myocardial infarction. We synthesized the biodegradable material with the biochemical with are approved for the usage in Human. And we proved that the ratio of the compounds can change the physical property. Also we identified the most appropriate mechanical property of the material for the heart in Human. The suitable biocompatibility of the material was proven in the transplant into rat hearts.

Research Products

• [Presentation] 心臓血管外科領域の再生医療～生体吸収性形状記憶材料開発と右室流出路での有用性評価 (2017)
  • Author(s): 藤本和朗
  • Organizer: 第47回日本心臓血管外科学会定期学術集会
  • Place of Presentation: グランドニッコー東京台場（東京都港区）
  • Year and Date: 2017-02-27
• [Presentation] 心臓血管外科領域の再生医療～生体吸収性形状記憶材料開発と右室流出路での有用性評価 (2017)
  • Author(s): 藤本和朗, 碓氷章彦, 大島英揮, 成田裕司, 緒方藍歌, 荏原充宏
  • Organizer: 第47回日本心臓血管外科学会学術総会
• [Presentation] 心臓再生医療への形状記憶生体材料の開発と生体適合性の評価 (2015)
  • Author(s): 藤本和朗
  • Organizer: 第68回日本胸部外科学会定期学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県神戸市）
  • Year and Date: 2015-10-17