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Development of novel elastic biodegradable material for improve cardiac function with regenerating cardiomyocytes post myocardial infarction

Research Project

Project/Area Number 26462086
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionNagoya University

Principal Investigator

FUJIMOTO KAZURO  名古屋大学, 医学部附属病院, 病院講師 (70644665)

Co-Investigator(Kenkyū-buntansha) 碓氷 章彦  名古屋大学, 医学系研究科, 教授 (30283443)
大島 英揮  名古屋大学, 医学系研究科, 准教授 (40378188)
成田 裕司  名古屋大学, 医学部附属病院, 講師 (60378221)
緒方 藍歌  名古屋大学, 医学系研究科, 特任助教 (70718311)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords生体吸収材料 / 心臓 / 物理的特性 / 生体材料 / 形状記憶ポリマー / 心筋再生 / 心筋梗塞 / 弾力生体材料 / 再生医療
Outline of Final Research Achievements

We developed the biodegradable material for the preservation of the cardiac function to restrict cardiac remodeling post myocardial infarction. We synthesized the biodegradable material with the biochemical with are approved for the usage in Human. And we proved that the ratio of the compounds can change the physical property. Also we identified the most appropriate mechanical property of the material for the heart in Human. The suitable biocompatibility of the material was proven in the transplant into rat hearts.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2017 2015

All Presentation (3 results)

  • [Presentation] 心臓血管外科領域の再生医療~生体吸収性形状記憶材料開発と右室流出路での有用性評価2017

    • Author(s)
      藤本和朗
    • Organizer
      第47回日本心臓血管外科学会定期学術集会
    • Place of Presentation
      グランドニッコー東京台場(東京都港区)
    • Year and Date
      2017-02-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 心臓血管外科領域の再生医療~生体吸収性形状記憶材料開発と右室流出路での有用性評価2017

    • Author(s)
      藤本和朗, 碓氷章彦, 大島英揮, 成田裕司, 緒方藍歌, 荏原充宏
    • Organizer
      第47回日本心臓血管外科学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 心臓再生医療への形状記憶生体材料の開発と生体適合性の評価2015

    • Author(s)
      藤本和朗
    • Organizer
      第68回日本胸部外科学会定期学術集会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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