Establishment of physiological hemodynamic simulation for optimization of coronary artery bypass grafting anastomosis

• Project/Area Number: 26462092
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Kitasato University
• Principal Investigator: Miyaji Kagami 北里大学, 医学部, 教授 (40281703)
• Co-Investigator(Kenkyū-buntansha): 板谷 慶一 京都府立医科大学, 医学(系)研究科(研究院), 講師 (70458777)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 冠動脈バイパス術 / 血行動態 / 血流解析 / 仮想手術シミュレーション / CFD / コンピューター血流シミュレーション / 仮想手術 / 一般化モデル / コンピュータ血流シミュレーション

Outline of Final Research Achievements

The hemodynamic evaluation system by using mock operation of coronary artery bypass grafting were established and was implemented to clinical settings. Validation was also performed in several cases. The optimal morphology of the anastomoses were confirmed, these findings will contribute to long-term patency of the graft. The research results were presented at conferences and published.

Research Products

• [Journal Article] Two-stage operation for Stanford type A acute aortic dissection originating from Kommerell's diverticulum. (2016)
  • Author(s): Tanaka Y, Kitamura T, Horai T, Miyaji K
  • Journal Title: Interact Cardiovasc Thorac Surg Volume: 22 Issue: 5 Pages: 695-7
  • DOI: 10.1093/icvts/ivw011
  • Peer Reviewed / Open Access
• [Journal Article] Aorto-Left Ventricular Tunnel Successfully Repaired Immediately After Birth (2016)
  • Author(s): Nakamura Y, Miyaji K, Yoshii T, Ootomo Y, Kimura S
  • Journal Title: Ann Thorac Surg Volume: 101 Issue: 5 Pages: 1988-90
  • DOI: 10.1016/j.athoracsur.2015.06.105
  • Peer Reviewed / Open Access
• [Journal Article] Randomized Study of a New Noninvasive Skin Closure Device for Use After Congenital Heart Operations (2016)
  • Author(s): Tanaka Y, Miyamoto T, Naito Y, Yoshitake S, Sasahara A, Miyaji K
  • Journal Title: Ann Thorac Surg Volume: 102 Issue: 4 Pages: 1368-74
  • DOI: 10.1016/j.athoracsur.2016.03.072
  • Peer Reviewed / Open Access
• [Journal Article] Synchronization of the Flow and Pressure Waves Obtained With Non-Simultaneous Multipoint Measurements (2016)
  • Author(s): Goto S, Nakamura M, Itatani K, Miyazaki S, Oka N, Honda T, Kitamura T, Horai T, Ishii M, Miyaji K
  • Journal Title: International Heart Journal Volume: 57 Issue: 4 Pages: 449-455
  • DOI: 10.1536/ihj.15-440
  • NAID: 130006895904
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed
• [Journal Article] Contributions of Respiration and Heartbeat to the Pulmonary Blood Flow in the Fontan Circulation (2016)
  • Author(s): Honda T, Itatani K, Takanashi M, Kitagawa A, Ando H, Kimura S, Nakahata Y, Oka N, Miyaji K, Ishii M
  • Journal Title: Ann Thorac Surg Volume: 102 Issue: 5 Pages: 1596-160
  • DOI: 10.1016/j.athoracsur.2016.03.101
  • Peer Reviewed / Open Access
• [Journal Article] Impact of top end anastomosis design on patency and flow stability in coronary artery bypass grafting. (2016)
  • Author(s): Koyama S, Kitamura T, Itatani K, Yamamoto T, Miyazaki S, Oka N, Nakashima K, Horai T, Ono M, Miyaji K.
  • Journal Title: Heart Vessels. Volume: 31 Issue: 5 Pages: 643-8
  • DOI: 10.1007/s00380-015-0680-2
  • Peer Reviewed
• [Journal Article] Optimal Graft Size of Modified Blalock-Taussig Shunt for Biventricular Circulation in Neonates and Small Infants (2015)
  • Author(s): Shibata M, Itatani K, Oka N, Yoshii T, Nakamura Y, Kitamura T, Horai T, Miyaji K.
  • Journal Title: International Heart Journal Volume: 56 Issue: 5 Pages: 533-536
  • DOI: 10.1536/ihj.15-042
  • NAID: 130005102131
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed
• [Journal Article] Increased systemic cardiac output improves arterial oxygen saturation in bidirectional cavopulmonary shunt. (2015)
  • Author(s): Oka N, Miyaji K, Kitamura T, Itatani K, Yoshii T, Inoue N, Fukunishi T, Shibata K, Torii S
  • Journal Title: Heart Vessels. Volume: 30 Issue: 1 Pages: 56-60
  • DOI: 10.1007/s00380-013-0438-7
  • Peer Reviewed
• [Journal Article] Vortex flow energy loss reflects therapeutic effect in dilated cardiomyopathy. (2015)
  • Author(s): Nabeta T, Itatani K, Miyaji K, Ako J
  • Journal Title: Eur Heart J Volume: 36 Issue: 11 Pages: 637-637
  • DOI: 10.1093/eurheartj/ehu394
  • Peer Reviewed
• [Journal Article] Impact of the entry site on late outcome in acute Stanford type B aortic dissection (2015)
  • Author(s): Kitamura T, Torii S, Oka N, Horai T, Itatani K, Yoshii T, Nakamura Y, Shibata M, Tamura T, Araki H, Matsunaga Y, Sato H, Miyaji K
  • Journal Title: Eur J Cardiothorac Surg Volume: in-press
  • Peer Reviewed
• [Journal Article] Optimal bypass graft design for left anterior descending and diagonal territory in multivessel coronary disease (2014)
  • Author(s): Koyama S, Itatani K, Yamamoto T, Miyazaki S, Kitamura T, Taketani T, Ono M, Miyaji K
  • Journal Title: Interact Cardiovasc Thorac Surg. Volume: 19(3)
  • Peer Reviewed
• [Journal Article] グラフトデザインと冠動脈 (2014)
  • Author(s): 小山紗千 板谷慶一
  • Journal Title: 呼吸と循環 Volume: 62
• [Presentation] Computational Blood Flow Analysis of the Aortic Arch and the Neck Vessels: Total Arch Replacement vs Stent Graft With Neck Vessel Debranching (2016)
  • Author(s): Horai T, Kitamura T, Torii S, Sughimoto K, Kobayashi K, Irisawa Y, Hayashi H, Matsushiro T, Tsuchida Y, Miyata Y, Miyaji K
  • Organizer: The American Heart Association's Scientific Sessions 2016
  • Place of Presentation: New Orleans (U.S.A)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Surgical Strategy for Aortic Arch Reconstruction after Norwood Procedure based on a Virtual Operation with Numerical Flow Analysis (2016)
  • Author(s): Miyazaki S, Itatani k, Oka N, Goto S, Nakamura M, Kitamura T, Horai T, Nakamura Y, Miyaji K
  • Organizer: American Association for Thoracic Surgery 99th Annual Meeting
  • Place of Presentation: Baltimore (U.S.A.)
  • Year and Date: 2016-05-14
  • Int'l Joint Research
• [Presentation] Accuracy of small sized vessel flow measurements in 3D cine PC MRI with respiratory navigator gating (2015)
  • Author(s): Miyazaki S,Itatani K,Hata H,Inoue
  • Organizer: 10th World Congress for Microcirculation
  • Place of Presentation: 京都国際会議場（京都市）
  • Year and Date: 2015-09-25
  • Int'l Joint Research
• [Presentation] Influence of Vessel Curvature and Bifurcation on Risk of Plaque Progression and Rupture in Coronary Artery Disease (2015)
  • Author(s): Koyama S, Yamamoto T, Itatani K, Miyazaki S, Ono M
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2015-04-25 – 2015-04-26
• [Presentation] Influence of Vessel Curvature and Bifurcation on Risk of PPlaque Progression and Rupture in Coronary Artery Disease (2015)
  • Author(s): Yamamoto T, Itatani K, Miyazaki S, Ono M
  • Organizer: 日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2015-04-25
• [Presentation] Energy Dynamics of the Intraventricular Vortex after the Mitral Valve Surgery (2015)
  • Author(s): Itatani K, Nakashima K, Kitamura T, Oka N, Horai T, Miyazaki S,Miyaji K
  • Organizer: AATS Mitral Conclave
  • Place of Presentation: ニューヨーク（アメリカ）
  • Year and Date: 2015-04-23
  • Int'l Joint Research
• [Presentation] 大動脈弁置換術後生体弁機能評価における心臓超音波血流評価法 Vector Flow Mappingの有用性 (2015)
  • Author(s): 荒記春奈 板谷慶一 柿崎良太 宝来哲也 北村律 宮地鑑
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-04-16