| Project/Area Number |
26462093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
内山 雅照 帝京大学, 医学部, 助手 (60713295)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | HMG-CoA還元酵素阻害薬 / マウス / 心臓移植 / 拒絶反応 / 冠動脈 / 内膜肥厚 / 制御性T細胞 / プラバスタチン / BTLA / 移植免疫 / 冠動脈内膜肥厚 / 慢性拒絶反応 |
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| Outline of Final Research Achievements |
We investigated the effects on the graft survival of HMG-CoA reductase inhibitor Pravastatin, an anti-arteriosclerosis drug, in the murine cardiac transplant model. Our models injected intraperitoneally with one dose of 10 µg/day of Pravastatin for 7 days after grafting had the significant prolongation of graft survival and the generation of regulatory T cells. Morphometric analysis showed the suppression of intimal hyperplasia in left coronary arteries of donor B6 heart from Pravastatin-exposed recipients. Moreover, the addition of Pravastatin to allogeneic mix leukocyte culture could inhibit alloproliferation in a dose-dependent manner. This study has been published in Transplantation Proceedings.
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