Analysis of cardiac allograft protective effect by HMG-CoA reductase inhibitor and anti-BTLA monoclonal antibody
Project/Area Number |
26462093
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular surgery
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Research Institution | Teikyo University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
内山 雅照 帝京大学, 医学部, 助手 (60713295)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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Keywords | HMG-CoA還元酵素阻害薬 / マウス / 心臓移植 / 拒絶反応 / 冠動脈 / 内膜肥厚 / 制御性T細胞 / プラバスタチン / BTLA / 移植免疫 / 冠動脈内膜肥厚 / 慢性拒絶反応 |
Outline of Final Research Achievements |
We investigated the effects on the graft survival of HMG-CoA reductase inhibitor Pravastatin, an anti-arteriosclerosis drug, in the murine cardiac transplant model. Our models injected intraperitoneally with one dose of 10 µg/day of Pravastatin for 7 days after grafting had the significant prolongation of graft survival and the generation of regulatory T cells. Morphometric analysis showed the suppression of intimal hyperplasia in left coronary arteries of donor B6 heart from Pravastatin-exposed recipients. Moreover, the addition of Pravastatin to allogeneic mix leukocyte culture could inhibit alloproliferation in a dose-dependent manner. This study has been published in Transplantation Proceedings.
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Report
(5 results)
Research Products
(25 results)
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[Journal Article] Regulatory T cells for tolerance2018
Author(s)
Kento Kawai, Masateru Uchiyama, Joanna Hester, Kathryn Wood, Fadi Issa
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Journal Title
Human Immunology
Volume: 79
Issue: 5
Pages: 294-303
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Seven Japanese Herbals Prolonged Cardiac Allograft Survival.2018
Author(s)
Enzhi Yin, Xiangyuan Jin, Masateru Uchiyama, Qi Zhang, Takako Yanagisawa, Akira Inoue, Yu Guo, Masanori Hara, Shigefumi Matsuyama, Tomohiro Imazuru, Masafumi Kawamura, and Masanori Niimi
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Journal Title
Transplantation Proceedings
Volume: 印刷中
Issue: 9
Pages: 2789-93
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Anti-CD272 antibody (6B2) induced prolongation of fully MHC-mismatched murine cardiac allograft and generation of Foxp3+ regulatory T cells2017
Author(s)
Masateru Uchiyama, Xiangyuan Jin, Enzhi Yin, Takako Yanagisawa, Akira Inoue, Masanori Hara, Shigefumi Matsuyama, Tomohiro Imazuru, Hideo Yagita, Masafumi Kawamura, and Masanori Niimi
Organizer
アジア移植学会2017
Place of Presentation
フィリピン・セブ
Year and Date
2017-11-27
Related Report
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[Presentation] 心臓リハビリテーションにおける嚥下機能評価について2015
Author(s)
川勝 寛之, 川崎 宗泰, 長雄 寛之, 徳弘 圭一, 新津 勝士, 原 真範, 萩野谷 哲秀, 榎 恵美子, 澤田 由紀子, 武田 友佳, 齋藤 小春, 三好 英一, 高橋 杏奈, 森田 祥之
Organizer
第21回 日本心臓リハビリテーション学会学術集会
Place of Presentation
福岡県・福岡国際会議場、福岡サンパレス
Year and Date
2015-07-18
Related Report
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