| Project/Area Number |
26462094
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cardiovascular surgery
|
|---|
| Research Institution | Osaka Medical College |
|---|
Principal Investigator |
OZAWA HIDEKI 大阪医科大学, 医学部, 講師 (20277156)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
根本 慎太郎 大阪医科大学, 医学部, 教授 (20237811)
中澤 靖元 東京農工大学, 工学(系)研究科(研究院), 准教授 (20456255)
星賀 正明 大阪医科大学, 医学部, 教授 (90309154)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Ryo 東京農工大学, 農学部, 准教授 (70334480)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Keywords | 心臓修復材料 / fibroin / 高分子ポリマー / エレクトロスピニング法 / 先天性心疾患 / 外科治療 / 手術材料 / パッチ |
|---|
| Outline of Final Research Achievements |
The existing sheets widely used in pediatric cardiac surgery often need to be replaced as in reoperation because of degradation, calcification, and infection of the sheets. A new synthetic sheet was developed to solve the problems by optimizing mechanical property and biocompatibility. The sheet was made by electrospinning method using a mixture of silk fibroin (SF) and a synthetic polymer, thermoplastic polyurethane (TPU). Flexibility, water permeability, and suture retention strength of the SF/TPU sheet were excellent and equivalent to the existing sheets. When the SF/TPU sheet was implanted in the canine aorta, the intraluminal surface of the sheet was covered with restored tissue with no calcium deposition and modest inflammatory reaction. There was no sign of patch degradation in short time after the implantation. These favorable features and possible biodegradability of the SF portion warrant a long-term follow-up study.
|
