| Project/Area Number |
26462095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
伊井 正明 大阪医科大学, その他部局等, 講師 (10442922)
神吉 佐智子 大阪医科大学, 医学部, 助教 (40411350)
打田 裕明 大阪医科大学, 医学部, 助教 (70736834)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脂肪由来幹細胞 / 虚血性心筋症 / 再生医療 / 心筋組織由来間葉系幹細胞 / 心不全 / 脂肪組織由来間葉系幹細胞 |
|---|
| Outline of Final Research Achievements |
Adipose tissue derived stromal cells (AdSC) have been reported to differentiate into multiple lineages such as osteoblasts, skeletal muscle cells, cardiomyocytes, vascular endothelial cells, and nerve cells. In this study, we isolated human pericardial adipose-derived stem cells (CA-AdSC) and human subcutaneous fat derived stem cells (SC-AdSC) from surgical patients with informed consent under institutional ethical committee approval. The isolated and propagated AdSC showed higher density than SC-AdSC. The proliferation capacity, migratory ability and anti-apoptotic property were significantly higher in CA-AdSC.
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