• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Paraplegia preventsion by oral pretreatment with memanthine in a animal model

Research Project

Project/Area Number 26462099
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionToho University

Principal Investigator

SAITO Aya  東邦大学, 医学部, 准教授 (10431868)

Co-Investigator(Kenkyū-buntansha) 本村 昇  東邦大学, 医学部, 教授 (40332580)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords脊髄虚血 / メマンチン / 大血管外科手術
Outline of Final Research Achievements

We evaluated the role of memantine (N-methyl-D-aspartate receptor antagonist) pretreatment for the prevention of spinal cord ischemia after infrarenal aortic clamping in a rabbit model. New Zealand White rabbits were pretreated with memantine (180mg/7days) before the procedure.Oral memantine preteatment was initially scheduled however, it was changed to subdermal administration for possibly more stable pretreatment. During the experiment, parameters indicating hemodynamic changes (arterial pressure, heart rate, Cardio-Ankle Vascular Index) were monitered, and no particular changes / patterns were observed in the pretreated rabbits. Then, the animals were sacrificed, and spinal chords were removed / submitted to pathological examination with HE stain, which no specific / non-specific changes were observed in the pretreated rabbits. In conclusions, subdermal memantine pretreatmend had minimal influence on the hemodynamic and qualitative changed to spinal chord in our animal experiment.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2018 2016

All Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] Evaluation of Vascular Function after AVR in AS patients by CAVI and FMD2018

    • Author(s)
      Ito Y, Saito A, Motomura N
    • Organizer
      82th annual meeting of th Japanese Circulation Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Assessment of dynamic changes in aortic wall stiffness during aortic clamp/declamp maneuver in rabbits2016

    • Author(s)
      Aya Saito, Noboru Motomura, Yuya Ito, Kazuhiro Shimizu, Mao Takahashi, Akira Takahara, Koji Shirai
    • Organizer
      第69回日本胸部外科学会定期学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Year and Date
      2016-09-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Changes of Aortic Stiffness during Aortic Clamp / Declamp maneuver2016

    • Author(s)
      Aya SAITO,Noboru Motomura, Yuya Ito, Kazuhiro Shimizu, Mao Takahashi, Akira Takahara, Koji Shirai
    • Organizer
      Hypertension Seoul 2016
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-09-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Changes of Aortic Stiffness during Aortic Clamp / Declamp Maneuver2016

    • Author(s)
      Aya Saito, Noboru Motomura, Yuya Ito, Kazuhiro Shimizu, Mao Takahashi, Akira Takahara, Koji Shirai
    • Organizer
      Hypertension Seoul 2016
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] CHANGES OF AORTIC STIFFNESS DURING AORTIC CLAMP / DECLAMP MANEUVER2016

    • Author(s)
      Aya SAITO、Noboru MOTOMURA, Yuya Ito, Kazuhiro Shimizu, Mao Takahashi, Akira TAKAHARA, Kohji SHIRAI
    • Organizer
      Asian Society of Cardiovascular and Thoracic Surgery
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-04-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi