Paraplegia preventsion by oral pretreatment with memanthine in a animal model

• Project/Area Number: 26462099
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Toho University
• Principal Investigator: SAITO Aya 東邦大学, 医学部, 准教授 (10431868)
• Co-Investigator(Kenkyū-buntansha): 本村 昇 東邦大学, 医学部, 教授 (40332580)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 脊髄虚血 / メマンチン / 大血管外科手術

Outline of Final Research Achievements

We evaluated the role of memantine (N-methyl-D-aspartate receptor antagonist) pretreatment for the prevention of spinal cord ischemia after infrarenal aortic clamping in a rabbit model. New Zealand White rabbits were pretreated with memantine (180mg/7days) before the procedure.Oral memantine preteatment was initially scheduled however, it was changed to subdermal administration for possibly more stable pretreatment. During the experiment, parameters indicating hemodynamic changes (arterial pressure, heart rate, Cardio-Ankle Vascular Index) were monitered, and no particular changes / patterns were observed in the pretreated rabbits. Then, the animals were sacrificed, and spinal chords were removed / submitted to pathological examination with HE stain, which no specific / non-specific changes were observed in the pretreated rabbits. In conclusions, subdermal memantine pretreatmend had minimal influence on the hemodynamic and qualitative changed to spinal chord in our animal experiment.

Research Products

• [Presentation] Evaluation of Vascular Function after AVR in AS patients by CAVI and FMD (2018)
  • Author(s): Ito Y, Saito A, Motomura N
  • Organizer: 82th annual meeting of th Japanese Circulation Society
• [Presentation] Assessment of dynamic changes in aortic wall stiffness during aortic clamp/declamp maneuver in rabbits (2016)
  • Author(s): Aya Saito, Noboru Motomura, Yuya Ito, Kazuhiro Shimizu, Mao Takahashi, Akira Takahara, Koji Shirai
  • Organizer: 第69回日本胸部外科学会定期学術集会
  • Place of Presentation: 岡山コンベンションセンター（岡山県岡山市）
  • Year and Date: 2016-09-28
• [Presentation] Changes of Aortic Stiffness during Aortic Clamp / Declamp maneuver (2016)
  • Author(s): Aya SAITO,Noboru Motomura, Yuya Ito, Kazuhiro Shimizu, Mao Takahashi, Akira Takahara, Koji Shirai
  • Organizer: Hypertension Seoul 2016
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-09-28
  • Int'l Joint Research
• [Presentation] Changes of Aortic Stiffness during Aortic Clamp / Declamp Maneuver (2016)
  • Author(s): Aya Saito, Noboru Motomura, Yuya Ito, Kazuhiro Shimizu, Mao Takahashi, Akira Takahara, Koji Shirai
  • Organizer: Hypertension Seoul 2016
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-09-25
• [Presentation] CHANGES OF AORTIC STIFFNESS DURING AORTIC CLAMP / DECLAMP MANEUVER (2016)
  • Author(s): Aya SAITO、Noboru MOTOMURA, Yuya Ito, Kazuhiro Shimizu, Mao Takahashi, Akira TAKAHARA, Kohji SHIRAI
  • Organizer: Asian Society of Cardiovascular and Thoracic Surgery
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2016-04-08
  • Int'l Joint Research