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Analysis of phlebolymphedema in edema

Research Project

Project/Area Number 26462103
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Yamamoto Naoto  浜松医科大学, 医学部附属病院, 助教 (80402262)

Co-Investigator(Kenkyū-buntansha) 海野 直樹  浜松医科大学, 医学部, 准教授 (20291958)
Research Collaborator TANAKA Hiroki  
SANO Masaki  
SAITO Takaaki  
SUGISAWA Ryota  
KATAHASHI Kazuto  
YATA Tatsuro  
KAYAMA Takafumi  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords浮腫 / リンパ浮腫 / 慢性静脈不全 / 深部静脈血栓症 / 静脈血栓症
Outline of Final Research Achievements

We investigate the effects of insuffi¬cient lymph drainage on vein walls. In rats, the lymphatic collecting vessels sur¬rounding the femoral vein were ligated, which caused the local retention of lymphatic fluid. A histological study of the fem¬oral vein and the surrounding tissue was con¬ducted. IMS was used to analyze the distribution of lipid molecules in the perivascular tissue.
After the procedure, the lymphatic vessels in the model tissue were significantly dilated. Compared with the control tissue, the model tissue exhibited marked perivascular accumulation of lysophosphatidylcholine, phosphatidylcholine, and triglycerides. The walls of the femoral veins were 3.4-fold thicker than the control. The number of TNF-α positive adipocytes was increased in the perivascular regions of the model tissue. The accumulation of lymphatic fluid changes the structure of vein walls, and such changes might be associated with chronic venous insufficiency.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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