Relationship between wall shear stress and angiogenesis, lymphangiogenesis in abdominal aortic aneurysm

• Project/Area Number: 26462105
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: INUZUKA Kazunori 浜松医科大学, 医学部附属病院, 助教 (00397415)
• Co-Investigator(Kenkyū-buntansha): 海野 直樹 浜松医科大学, 医学部, 准教授 (20291958)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 血管外科 / 腹部大動脈瘤 / MRI / ずり応力 / リンパ管 / 血管新生 / リンパ管新生 / 蛍光造影 / エンドリーク / 刷り応力 / PET / WRI

Outline of Final Research Achievements

Histological examination revealed chronic inflammation and angiogenesis / lymphangiogenesis in the intima and tunica media of the aortic aneurysm. 　Inflammatory cells, lymphangiogenesis, and lymphatic stasis were histologically observed in sites where lymphatic luminescence was remarkably evoked by ICG fluorescence imaging examination of the aortic wall. It was suggested that chronic inflammation and lymphangiogenesis are related to development and increase of aortic aneurysm.
The distribution of wall shear stress was not related to lymphangiogenesis or chronic inflammation.

Research Products

• [Journal Article] Topologic distributions of vasa vasorum and lymphatic vasa vasorum in the aortic adventitia - Implications for the prevalence of aortic diseases. (2016)
  • Author(s): Sano M, Unno N, Sasaki T, Baba S, Sugisawa R, Tanaka H, Inuzuka K, Yamamoto N, Sato K, Konno H.
  • Journal Title: Atherosclerosis Volume: 247 Pages: 127-134
  • DOI: 10.1016/j.atherosclerosis.2016.02.007
  • Peer Reviewed / Open Access
• [Journal Article] Hemodynamic Analysis of Endoleaks After Endovascular Abdominal Aortic Aneurysm Repair by Using 4-Dimensional Flow-Sensitive Magnetic Resonance Imaging (2016)
  • Author(s): Sakata M, Takehara Y, Katahashi K, Sano M, Inuzuka K, Yamamoto N, Sugiyama M, Sakahara H, Wakayama T, Alley MT, Konno H, Unno N
  • Journal Title: Circulation Journal Volume: 80 Issue: 8 Pages: 1715-1725
  • DOI: 10.1253/circj.CJ-16-0297
  • NAID: 130005166111
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Surgical Treatment of Abdominal Aortic Aneurysm with Congenital Solitary Pelvic Kidney and Superior Mesenteric Artery Stenosis (2016)
  • Author(s): Saito T, Tanaka H, Yamamoto N, Inuzuka K, Sano M, Unno N
  • Journal Title: Annals of Vascular Diseases Volume: 9 Issue: 3 Pages: 216-219
  • DOI: 10.3400/avd.cr.16-00022
  • NAID: 130005266720
  • ISSN: 1881-641X, 1881-6428
  • Peer Reviewed
• [Journal Article] 当院における術後・入院中に発症した有症状静脈血栓塞栓症症例の検討 (2016)
  • Author(s): 山本 尚人, 海野 直樹, 犬塚 和徳, 佐野 真規, 斉藤 貴明, 杉澤 良太, 片橋 一人, 矢田 達朗, 嘉山 貴文
  • Journal Title: 静脈学 Volume: 27 Pages: 13-20
  • NAID: 130005127594
  • Peer Reviewed
• [Journal Article] 巨大膝窩動脈瘤に対して内側・後方アプローチが有用であった1例 (2016)
  • Author(s): 嘉山 貴文, 山本 尚人, 佐野 真規, 矢田 達朗, 片橋 一人, 杉澤 良太, 斉藤 貴明, 犬塚 和徳, 海野 直樹
  • Journal Title: 血管外科 Volume: 35 Pages: 85-89
  • Peer Reviewed
• [Journal Article] Effects of Compression Stockings on Elevation of Leg Lymph Pumping Pressure and Improvement of Quality of Life in Healthy Female Volunteers: A Randomized Controlled Trial (2016)
  • Author(s): Sugisawa R, Unno N, Saito T, Yamamoto N, Inuzuka K, Tanaka H, Sano M, Katahashi K, Uranaka H, Marumo T, Konno H
  • Journal Title: Lymphatic Research and Biology Volume: 14
  • Peer Reviewed
• [Journal Article] Lymphatic Pumping Pressure in the Legs Is Associated with Leg Edema and Lower Quality of Life in Healthy Volunteers (2015)
  • Author(s): Saito T, Unno N, Yamamoto N, Inuzuka K, Tanaka H, Sano M, Sugisawa R, Katahashi K, Konno H. Low
  • Journal Title: Lymphatic Research and Biology Volume: 13 Pages: 154-159
  • Peer Reviewed
• [Journal Article] Utility of a preloaded fenestrated graft in thoracoabdominal aneurysm repair (2015)
  • Author(s): Unno N, Yamamoto N, Higashiura W, Inuzuka K, Sano M, Konno H
  • Journal Title: Asian Cardiovascular and Thoracic Annals Volume: 24
  • Peer Reviewed
• [Journal Article] Imaging Mass Spectrometry Reveals a Unique Distribution of Triglycerides in the Abdominal Aortic Aneurysmal Wall. (2015)
  • Author(s): Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Sano M, Saito T, Hayasaka T, Goto-Inoue N, Sato K, Kugo H, Moriyama T, Konno H, Setou M, Unno N.
  • Journal Title: J Vasc Res Volume: 52 Issue: 2 Pages: 127-135
  • DOI: 10.1159/000439169
  • Peer Reviewed / Open Access
• [Journal Article] Characteristic Distribution Pattern of Lysophosphatidylcholine in Fibromuscular Dysplasia-Associated Visceral Artery Aneurysms Compared with Atherosclerotic Visceral Artery Aneurysms (2015)
  • Author(s): Hiroki Tanaka, Nobuhiro Zaima, Takeshi Sasaki, Naoto Yamamoto, Kazunori Inuzuka, Masaki Sano, Hiroyuki Konno, Tetsumei Urano, Mitsutoshi Setou, Naoki Unno
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22
  • NAID: 130005154756
  • Peer Reviewed
• [Journal Article] Hypoperfusion of the Adventitial Vasa Vasorum Develops an Abdominal Aortic Aneurysm (2015)
  • Author(s): Tanaka H, Zaima N, Sasaki T, Sano M, Yamamoto N, Saito T, Inuzuka K, Hayasaka T, Goto-Inoue N, Sugiura Y, Sato K, Kugo H, Moriyama T, Konno H, Setou M, Unno N
  • Journal Title: PLoS One Volume: 10
  • Peer Reviewed
• [Journal Article] Early outcomes of iliac branch grafts in the endovascular repair of abdominal aortic aneurysms with concomitant bilateral common iliac artery aneurysms at a Japanese institution (2014)
  • Author(s): Unno N, Yamamoto N, Inuzuka K, Mano Y, Sano M, Saito T, Sugisawa R, Katahashi K, Konno H
  • Journal Title: Surgery Today Volume: 44
  • Peer Reviewed
• [Presentation] 前腕尺側皮静脈を用いたバスキュラーアクセスの成績と意義 (2017)
  • Author(s): 犬塚和徳, 海野直樹, 山本尚人, 佐野真規, 斉藤貴明, 杉澤良太, 片橋一人, 矢田達朗, 嘉山貴文
  • Organizer: 第47回日本心臓血管外科学会学術総会
  • Place of Presentation: グランドニッコー東京・台場（東京）
  • Year and Date: 2017-02-27
• [Presentation] スチール症候群に対する光電式容積脈波法を用いた術中手指血圧の評価 (2016)
  • Author(s): 犬塚和徳, 海野直樹, 山本尚人, 佐野真規, 斉藤貴明, 杉澤良太, 片橋一人, 矢田達朗, 嘉山貴文
  • Organizer: 第20回日本アクセス研究会学術集会
  • Place of Presentation: 熊本県立劇場（熊本）
  • Year and Date: 2016-11-12
• [Presentation] Hemodynamic studies of superior mesenteric arteries to identify underlying causes of the spontaneous isolated dissections using flow-sensitive four-dimensional magnetic resonance imaging (2016)
  • Author(s): Inuzuka K, Unno N, Yamamoto N, Sano M, Saito T, Sugisawa R, Katahashi K, Yata T, Kayama T
  • Organizer: 27th World Congress of the International Union of Angiology
  • Place of Presentation: Centre de Congrs Internationale (Lyon, France)
  • Year and Date: 2016-10-07
  • Int'l Joint Research
• [Presentation] 前腕の尺側皮静脈転位による透析用ブラッドアクセスの早期成績 (2016)
  • Author(s): 犬塚和徳, 海野直樹, 山本尚人, 佐野真規, 斉藤貴明, 杉澤良太, 片橋一人, 矢田達朗, 嘉山貴文
  • Organizer: 第36回日本静脈学会総会
  • Place of Presentation: ホテルナクアシティ弘前（青森）
  • Year and Date: 2016-06-24
• [Presentation] 孤立性上腸間膜動脈解離の好発部位に関する血流力学的検討 (2016)
  • Author(s): 犬塚和徳, 海野直樹, 山本尚人, 佐野真規, 斉藤貴明, 杉澤良太, 片橋一人, 矢田達朗, 嘉山貴文
  • Organizer: 第44回日本血管外科学会学術総会
  • Place of Presentation: ホテル グランパシフィック LE DAIBA（東京）
  • Year and Date: 2016-05-27
• [Presentation] Hostile neckを有する腹部大動脈瘤に対するステントグラフト内挿術の治療成績 (2016)
  • Author(s): 犬塚和徳, 海野直樹, 山本尚人, 佐野真規, 斉藤貴明, 杉澤良太, 片橋一人, 矢田達朗, 嘉山貴文, 今野弘之
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪国際会議場／リーガロイヤルホテル大阪（大阪）
  • Year and Date: 2016-04-15
• [Presentation] 症候性孤立性上腸間膜動脈解離の解剖学的特徴 (2016)
  • Author(s): 犬塚和徳，海野直樹，山本尚人，田中宏樹、佐野真規，斉藤貴明，杉澤良太、片橋一人、矢田達朗、嘉山貴文
  • Organizer: 第52回日本腹部救急医学会総会
  • Place of Presentation: 京王プラザホテル（東京）
  • Year and Date: 2016-03-04
• [Presentation] 孤立性上腸間膜動脈解離の解剖学的特徴についての検討 (2015)
  • Author(s): 犬塚和徳，海野直樹，山本尚人，田中宏樹、佐野真規，斉藤貴明，杉澤良太、片橋一人、矢田達朗、嘉山貴文
  • Organizer: 第56回日本脈管学会総会
  • Place of Presentation: 虎ノ門ヒルズフォーラム（東京）
  • Year and Date: 2015-10-30
• [Presentation] 破裂性腹部大動脈瘤に対するステントグラフト内挿術の治療経験 ～緊急時デバイス入手困難な施設での現状～ (2015)
  • Author(s): 犬塚和徳，海野直樹，山本尚人，田中宏樹、佐野真規，斉藤貴明，杉澤良太、片橋一人、矢田達朗
  • Organizer: 第21回血管内治療学総会
  • Place of Presentation: 名古屋国際会議場（名古屋）
  • Year and Date: 2015-07-24
• [Presentation] 中枢ネックのIFU 外症例に対するステントグラフト内挿術の治療成績 (2015)
  • Author(s): 犬塚和徳，海野直樹，山本尚人，田中宏樹、佐野真規，斉藤貴明，杉澤良太、片橋一人、矢田達朗
  • Organizer: 第43回日本血管外科学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2015-06-03
• [Presentation] 光電式容積脈波法を用いた透析シャント盗血症候群に対する術中手指血圧の評価 (2014)
  • Author(s): 犬塚和徳、海野直樹、山本尚人、眞野勇記、佐野真規、斉藤貴明、杉澤良太、片橋一人
  • Organizer: 第42回日本血管外科学会学術総会
  • Place of Presentation: リンクステーションホール青森（青森）
  • Year and Date: 2014-05-21 – 2014-05-23
• [Presentation] 腹部症状を有する孤立性腹部内臓動脈瘤解離10例の検討 (2014)
  • Author(s): 犬塚和徳、海野直樹、山本尚人、眞野勇記、佐野真規、斉藤貴明、杉澤良太、片橋一人
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-04-03 – 2014-04-05
• [Book] 消化器外科医に必要な ちょっと先いく画像診断 (2015)
  • Author(s): 犬塚和徳、海野直樹、今野弘之ほか
  • Total Pages: 240
  • Publisher: メジカルビュー社