| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The role of Vasohibin-1 on development of Angiotensin II-inducced abdominal aortic aneurysm was examined. Angiotensin II of 1,000ng/kg/min was infused into male Vasohibin-1 +/- mice via osmotic mini-pump for 4 weeks, then abdominal aortic aneurysm was evaluated. Contrary to our expectation, hetero-knock out of Vasohibin-1 had minor effect on abdominal aortic aneurysm formation in comparison to control mice. In addition, no difference was observed between groups regarding several protease activities. This result implies that Vasohibin-1 plays little role on development of abdominal aortic aneurysm.
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