Effect and molecular mechanism of Vasohibin on development of abdominal aortic aneurysm

• Project/Area Number: 26462106
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Okayama University
• Principal Investigator: UCHIDA HARUHITO 岡山大学, 医歯薬学総合研究科, 准教授 (00550857)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 腹部大動脈瘤 / バソヒビン１ / アンジオテンシン / 血管新生 / 大動脈瘤

Outline of Final Research Achievements

The role of Vasohibin-1 on development of Angiotensin II-inducced abdominal aortic aneurysm was examined. Angiotensin II of 1,000ng/kg/min was infused into male Vasohibin-1 +/- mice via osmotic mini-pump for 4 weeks, then abdominal aortic aneurysm was evaluated. Contrary to our expectation, hetero-knock out of Vasohibin-1 had minor effect on abdominal aortic aneurysm formation in comparison to control mice. In addition, no difference was observed between groups regarding several protease activities. This result implies that Vasohibin-1 plays little role on development of abdominal aortic aneurysm.

Research Products

• [Presentation] Vasohibin-2は大動脈瘤モデルマウスにおいて胸部大動脈瘤を増悪させる (2016)
  • Author(s): 奥山倫弘、内田治仁、梅林亮子、垣尾勇樹、田邊克幸、藤井泰宏、大澤 晋、 佐藤靖史、佐野俊二、和田 淳
  • Organizer: 第57回日本脈管学会総会
  • Place of Presentation: ホテル日航奈良、奈良市
  • Year and Date: 2016-10-14
• [Presentation] Exogenous Vasohibin-2 Exacerbates Angiotensin II-induced Ascending Aortic Aneurysms, (2016)
  • Author(s): Okuyama M, Uchida HA, Umebayashi Y, Kakio Y, Tanabe K, Sato Y, Wada J,
  • Organizer: Arteriosclerosis, Thrombosis, and Vascular Biology
  • Place of Presentation: Nashville, TN, USA
  • Year and Date: 2016-05-04
  • Int'l Joint Research
• [Presentation] Cilnidipine Attenuated Angiotensin II-induced Abdominal Aortic Aneurysms in Apolipoprotein E-deficient Mice (2015)
  • Author(s): Yuki Kakio, Haruhito A. Uchida, Ryoko Umebayashi, Jun Wada
  • Organizer: ATVB
  • Place of Presentation: SanFrancisco, CA, USA
  • Year and Date: 2015-05-07
  • Int'l Joint Research
• [Presentation] Leukocyte Calpain Deficiency Reduces Angiotensin II-induced Inflammation and Atherosclerosis in Hypercholesterolemic Mice (2015)
  • Author(s): Deborah A. Howatt, Anju Balakrishnan, Jessica J. Moorleghen, Debra L. Rateri, Haruhito A. Uchida, Jiro Takano, Takaomi Saido, Athar H. Chishti, Laurent Baud, Venkateswaran Subramanian
  • Organizer: ATVB
  • Place of Presentation: SanFrancisco, CA, USA
  • Year and Date: 2015-05-07
  • Int'l Joint Research
• [Presentation] Inducible Depletion of Calpain-2 Attenuates Angiotensin II-induced Abdominal Aortic Aneurysms in Male LDL Receptor Deficient Mice. (2015)
  • Author(s): Anju Balakrishnan, Deborah A. Howatt, Jessica J. Moorleghen, Haruhito A. Uchida, Jiro Takano, Takaomi Saido, Venkateswaran Subramanian.
  • Organizer: ATVB
  • Place of Presentation: SanFrancisco, CA, USA
  • Year and Date: 2015-05-07
  • Int'l Joint Research
• [Presentation] ホスホジエステラーゼIII阻害薬はcAMP-PKA経路を介した抗炎症作用によりアンジオテンシンII による腹部大動脈瘤形成を抑制する (2014)
  • Author(s): 梅林亮子、内田治仁、垣尾勇樹、 和田淳、槇野博史
  • Organizer: 日本脈管学会
  • Place of Presentation: 倉敷市、芸文館
  • Year and Date: 2014-10-30
• [Presentation] Intercellular Adhesion Molecule 1 Deficiency Attenuated Angiotensin II-induced Abdominal Aortic Aneurysms in Apolipoprotein E Deficient Mice. (2014)
  • Author(s): Haruhito Adam Uchida
  • Organizer: 2014 Aortic Symposium
  • Place of Presentation: Kentucky, USA
  • Year and Date: 2014-09-04
• [Presentation] Intercellular Adhesion Molecule 1 Deficiency Attenuated Angiotensin II-induced Abdominal Aortic Aneurysms in Apolipoprotein E Deficient Mice (2014)
  • Author(s): Haruhito Adam Uchida
  • Organizer: ATVB
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-05-02