| Project/Area Number |
26462113
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Saga University |
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Principal Investigator |
Itoh Manabu 佐賀大学, 医学部, 助教 (50555084)
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| Co-Investigator(Kenkyū-buntansha) |
中山 功一 佐賀大学, 医学部, 寄附講座教授 (50420609)
森田 茂樹 佐賀大学, 医学部, 客員研究員 (70243938)
野口 亮 佐賀大学, 医学部, 助教 (70530187)
迎 洋輔 佐賀大学, 医学部, 医員 (90746570)
野出 孝一 佐賀大学, 医学部, 教授 (80359950)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 血管外科 / 組織工学 / 再生医療 / 人工血管 / 心臓血管外科 / 小口径人工血管 / 血管再生 |
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| Outline of Final Research Achievements |
We generated scaffold-free tubular tissues from multicellular spheroids (MCS) composed of endothelial cells , smooth muscle cells and fibroblasts using a new tissue engineering, which were successfully implanted to nude rat and large animal (immunosuppressed mini pig) in an acute study. When the tubular tissues were matured in a perfusion system during more than one month, we confirmed resistance of more than 1000mmHg in the burst. Moreover, a layer structure similar to blood vessel was confirmed upon histopathologic testing and extracellular matrix production (outer side) as well as partial CD34-positive vascular endothelial cells on the inner side were confirmed.
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