Development of vascular regenerative therapy using new tissue engineering
| Project/Area Number |
26462113
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cardiovascular surgery
|
|---|
| Research Institution | Saga University |
|---|
Principal Investigator |
Itoh Manabu 佐賀大学, 医学部, 助教 (50555084)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
中山 功一 佐賀大学, 医学部, 寄附講座教授 (50420609)
森田 茂樹 佐賀大学, 医学部, 客員研究員 (70243938)
野口 亮 佐賀大学, 医学部, 助教 (70530187)
迎 洋輔 佐賀大学, 医学部, 医員 (90746570)
野出 孝一 佐賀大学, 医学部, 教授 (80359950)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 血管外科 / 組織工学 / 再生医療 / 人工血管 / 心臓血管外科 / 小口径人工血管 / 血管再生 |
|---|
| Outline of Final Research Achievements |
We generated scaffold-free tubular tissues from multicellular spheroids (MCS) composed of endothelial cells , smooth muscle cells and fibroblasts using a new tissue engineering, which were successfully implanted to nude rat and large animal (immunosuppressed mini pig) in an acute study. When the tubular tissues were matured in a perfusion system during more than one month, we confirmed resistance of more than 1000mmHg in the burst. Moreover, a layer structure similar to blood vessel was confirmed upon histopathologic testing and extracellular matrix production (outer side) as well as partial CD34-positive vascular endothelial cells on the inner side were confirmed.
|
Report
(4 results)
Research Products
(30 results)
-
-
-
-
-
-
-
[Journal Article] 内視鏡による術中評価を行った大動脈弁形成術2015
Author(s)
土井一義, 野口 亮, 迎 洋輔, 伊藤 学, 末永悦郎, 古川浩二郎, 森田茂樹, 伊藤 翼, 松本徳昭, 江﨑さおり, 原 明美, 恒松あゆみ．
-
Journal Title
胸部外科
Volume: 68(7)
Pages: 496-499
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
[Presentation] The effectiveness of using a bio-3D printer in the development of a scaffold-free regenerative vascular graft.2015
Author(s)
Itoh M, Mukae Y, Matsubayashi K, Kawakatsu M, Furukawa K, Uchihashi K, Toda S, Oyama J, Node K, Nakayama K, Morita S.
Organizer
TERMIS World Congres
Place of Presentation
Boston
Year and Date
2015-09-08
Related Report
Int'l Joint Research
-
-
-
-
-
[Presentation] 新規組織工学技術による次世代型小口径人工血管の開発2014
Author(s)
伊藤 学, 野口 亮, 山元博文, 佐藤 久, 諸隈宏之, 柚木純二, 蒲原啓司, 古川浩二郎, 中山功一, 尾山純一, 野出孝一, 森田茂樹
Organizer
第42回日本血管外科学会学術総会
Place of Presentation
青森
Year and Date
2014-05-21 – 2014-05-23
Related Report
-
-
-
-
-
-
-
-
