Integrated analysis followed by establishment of treatment strategy of Aortic aneurysm using genetic analysis and its derivatives.

• Project/Area Number: 26462114
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Yokohama City University
• Principal Investigator: MASUDA Munetaka 横浜市立大学, 医学研究科, 教授 (10190365)
• Co-Investigator(Kenkyū-buntansha): 井元 清隆 横浜市立大学, 附属市民総合医療センター, 教授 (40203335) ; 内田 敬二 横浜市立大学, 附属市民総合医療センター, 准教授 (50275062) ; 鈴木 伸一 横浜市立大学, 医学部, 准教授 (90285130)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 大動脈瘤 / 大動脈解離 / 遺伝子解析 / プロテオミクス解析 / 外科手術 / 解離性大動脈瘤 / 真性大動脈瘤 / プロテオミクス / 外科治療 / 動脈硬化 / 大血管外科学

Outline of Final Research Achievements

① Basic research:MYH11 chosen as a possible gene for aneurysm formation in human being using human aneurysm tissue by genetic analysis. . Proteomics analysis of human aneurysmal tissue revealed MYH11 is a useful biomarker of aneurysm formation and a useful predictor of atherosclerosis in human being.
② Clinical research:We revealed characteristics of patients with acute type A dissection of the aorta, and showed recent progress of surgical outcome of acute type A dissection in Japan. Impact of re-entry at the brachiocephalic artery after surgical repair on its prognosis evaluated. Various improvement of diagnosis tools and surgical technique reported.

Research Products

• [Journal Article] Evaluation and Influence of Brachiocephalic Branch Re-entry in Patients With Type A Acute Aortic Dissection (2017)
  • Author(s): Yasuda S, Imoto K, Uchida K, karube N, Minami T, Goda M, Suzuki S, Masuda M
  • Journal Title: Circulation Journal Volume: 81 Issue: 1 Pages: 30-35
  • DOI: 10.1253/circj.CJ-16-0462
  • NAID: 130005252653
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intermittent distal perfusion shortens hypothermic circulatory arrest time in aortic arch replacement surgery (2017)
  • Author(s): Goda M, Suzuki S, Yabu N, Goda M, Machida D, Masuda M
  • Journal Title: GeneralThoracic and Cardiovascular Surgery Volume: 65 Issue: 4 Pages: 239-241
  • DOI: 10.1007/s11748-016-0690-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Glutamate promotes constraction of the rat ductus arteriosus. (2016)
  • Author(s): Fujita S, Yokoyama U, Ishiwata R, Aoki R, Nagao K, masukawa D, Umemura M, Fujita T, Iwasaki S, Nishimaki S, Seki K, Ito S, Goshima Y, Asou T, Masuda M, Ishikawa Y
  • Journal Title: Circulation Journal Volume: 80 Pages: 2388-2396
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Confirmation of intimal tear in thrombosed-type acute aortic dissection by virtual angiocscopy (2016)
  • Author(s): Cho T, Tokunaga S, Izubuchi R, Masuda M
  • Journal Title: European Journal of vascular Endovascular Surgery Volume: 51 Issue: 6 Pages: 885-886
  • DOI: 10.1016/s1078-5884(16)30106-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Total arch replacement for coarctation of the aorta in an adolescent (2015)
  • Author(s): Kasama K, Suzuki S, Isomatsu Y, Yamazaki K, Yanagi H, Masuda M
  • Journal Title: Asian Cardiovascular & Thoracic Annals Volume: 23 Issue: 5 Pages: 576-578
  • DOI: 10.1177/0218492314523626
  • Peer Reviewed / Open Access
• [Journal Article] Coronary Subclavian Steal Syndrome Detected During Coronary Bypass Surgery in a Hemodialysis Patient (2015)
  • Author(s): Minami T, Imoto K, Uchida K, Karube N, Yasuda S, Choh T, Suzuki S, Masuda M
  • Journal Title: Journal of Cardiovascular Surgery Volume: 30 Pages: 154-156
  • Peer Reviewed / Open Access
• [Journal Article] The use of a self-expanding ring to facilitate distal anastomosis in total arch replacement (2015)
  • Author(s): Tokunaga S, Tanaka Y, Cho T, Izubuchi R, Masuda M
  • Journal Title: Turk gogus kalp damar cerrahisi dergisi Volume: 23 Pages: 176-177
  • Peer Reviewed / Open Access
• [Journal Article] A型急性大動脈解離の病態と治療成績 (2015)
  • Author(s): 内田敬二、輕部義久、安田章沢、宮本卓馬、松元佑介、磯田晋、郷田素彦、鈴木伸一、益田宗孝、井元清隆
  • Journal Title: 日本血管外科学会雑誌 Volume: 24 Pages: 127-134
  • NAID: 130005072428
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling. (2014)
  • Author(s): Yokoyama U, Minamisawa S, Sh ioda A, Ishiwata R, Jin MH, Masuda M, Asou T, Sugimoto Y, Aoki II, Nakamura T, and Ishikawa Y
  • Journal Title: Circulation. Volume: 129 Issue: 4 Pages: 487-496
  • DOI: 10.1161/circulationaha.113.004726
  • Peer Reviewed / Open Access
• [Journal Article] Decreased serum osmolality promotes ductus arteriosus constriction. (2014)
  • Author(s): Aoki R, Yokoyama U, Ichikawa Y, Taguri M, Kumagaya S, Ishiwata R, Yanai C, Fujita S, Umemura M, Fujita T, Okumura S, Sato M, Minamisawa S, Asou T, Masuda M, Iwasaki S, Nishimaki S, Seki K, Yokota S, Ishikawa Y.
  • Journal Title: Cardiovascular Research Volume: 104(2) Issue: 2 Pages: 326-36
  • DOI: 10.1093/cvr/cvu199
  • Peer Reviewed / Open Access
• [Journal Article] The use of surgical glue in acute type A aortic dissection (2014)
  • Author(s): Suzuki S, Masuda M, Imoto K
  • Journal Title: General Thoracic and cardiovascular Surgery Volume: 62 Issue: 4 Pages: 207-231
  • DOI: 10.1007/s11748-013-0343-0
  • Peer Reviewed / Open Access
• [Presentation] Fibulin-1は平滑筋郵送を介して動脈管内膜肥厚を誘導する (2016)
  • Author(s): 伊藤智子、横山歌子、益田宗孝、麻生俊英、石川義弘
  • Organizer: 第61回日本新生児成育医学会学術総会
  • Place of Presentation: 大阪国際会議場（大阪府）
  • Year and Date: 2016-12-01
• [Presentation] EP4 signaling in smooth muscle cells attracts inflamatory immune response in the aorta. (2016)
  • Author(s): Ishiwata R, Yokoyama U, Ichikawa Y, Kurotaki D, Yasuda S, Goda M, Suzuki S, Masuda M, tamura T, Ishikawa Y
  • Organizer: The 89th Scientific session, American Heart Association
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Patent(Industrial Property Rights)] 動脈硬化を検出するための血中バイオマーカー (2017)
  • Inventor(s): 横山歌子
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017-02-16