Cytokine valance in Patients with Immunoglobulin G4-Related Aortic Aneurysm
| Project/Area Number |
26462119
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cardiovascular surgery
|
|---|
| Research Institution | Department of Clinical Research, National Hospital Organization Kanazawa Medical Center |
|---|
Principal Investigator |
Kasashima Satomi 独立行政法人国立病院機構(金沢医療センター臨床研究部), その他部局等, その他 (20444200)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
尾崎 聡 金沢大学, 保健学系, 助教 (40401921)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KAWASHIMA Atsuhiro (KASASHIMA Fuminori) 金沢医療センター, 臨床検査科, 病理診断科, 部長 (90303304)
MATSUMOTO Yasushi 金沢医療センター, 心臓血管外科, 部長 (20262579)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
|---|
| Keywords | 大動脈瘤 / IgG4関連疾患 / サイトカイン / 炎症性大動脈瘤 / 自己免疫異常 / 動脈疾患 / サイトカインバランス |
|---|
| Outline of Final Research Achievements |
In this study, we identify a cytokine profile in the blood and local tissue of the patients with IgG4-AA, IgG4-AA), non-IgG4-related inflammatory abdominal aortic aneurysm, atherosclerotic AAA, almost normal aorta without dilatation were examined by (1) serum levels interleukin (IL)-4, IL-10, IL-13, and interferon (IFN)-g; (2) using resected the aortic tissues, immunohistochemical and mRNA-in situ hybrydization (ISH), local expression of the cytokines described above, CD34 , and CD163. Serum IL-10 in IgG4-AA were significantly higher than in atherosclerotic arteriopathies. IL-13 levels were elevated in 2 patients, all with IgG4-AA. Immunohistochemical analysis revealed that the number of immunopositive cells for IL-4, IL-10 and IL-13 were increased significantly in the adventitia of IgG4-AA than in aAAA and autopsy controls. ISH confirmed IL-10 and IL-13 mRNA expression in the adventitia of IgG4-AA. Co-expression of IL-13-mRNA and CD34-mRNA or CD168-mRNA was detected in IgG4-AA.
|
Report
(4 results)
Research Products
(20 results)
-
-
-
-
-
-
-
[Journal Article] Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: a retrospective multicenter study.2014
Author(s)
Mizushima I, Inoue D, Yamamoto M, Yamada K, Saeki T, Ubara Y, Matsui S, Masaki Y, Wada T, Kasashima S, Harada K, Takahashi H, Notohara K, Nakanuma Y, Umehara H, Yamagishi M, Kawano M.
-
Journal Title
Arthritis Res Ther.
Volume: 16
Issue: 4
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
