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Estrogen concentration in peripheral lung of Synchronous multiple lung adenocarcinomas

Research Project

Project/Area Number 26462131
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionKumamoto University

Principal Investigator

Shiraishi Kenji  熊本大学, 大学院生命科学研究部(医), 助教 (70363538)

Co-Investigator(Kenkyū-buntansha) 池田 公英  熊本大学, 医学部附属病院, 助教 (20448525)
鈴木 実  熊本大学, 大学院生命科学研究部(医), 教授 (80312940)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords多発肺腺癌 / エストロゲン / エスロトゲン / アロマターゼ / CYP19A1 / 肺腺癌
Outline of Final Research Achievements

In this study, we quantitated estrogen concentration in the peripheral lungs of postmenopausal female patients with synchronous multiple lung adenocarcinomas SMLA. The tissue concentration of estrogens (estrone [E1] and estdadiol [E2]) in the noncancerous peripheral lung were measured with liquid chromatography/electrospray tandem mass spectrometry in postmenopausal female patients with lung adenocarcinoma. The concentrations of E1 and E2 in the noncancerous tissue were significantly higher in SMLA cases than control cases. The minor allele (A) of single nucleotide polymorphism rs3764221 were significantly associated with higher concentration of E1 and E2 and higher CYP19A1 mRNA expression.
The tissue estrogen concentration of peripheral lung was significantly higher in SMLA than control cases. The high concentration of estrogen may be one of the causes of multicentric development of peripheral lung adenocarcinomas.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Synchronous Multiple Lung Adenocarcinomas: Estrogen Concentration in Peripheral Lung.2016

    • Author(s)
      Koei Ikeda
    • Journal Title

      PLoS One

      Volume: 11

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 閉経後女性における多発肺腺癌の発生とエストロゲン代謝の関連性の検討2016

    • Author(s)
      池田公英
    • Organizer
      第33回日本呼吸器外科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肺癌切除症例の背景肺におけるエストロゲン濃度の検討2015

    • Author(s)
      池田公英
    • Organizer
      日本肺癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2015-11-26
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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