Estrogen concentration in peripheral lung of Synchronous multiple lung adenocarcinomas

• Project/Area Number: 26462131
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Kumamoto University
• Principal Investigator: Shiraishi Kenji 熊本大学, 大学院生命科学研究部(医), 助教 (70363538)
• Co-Investigator(Kenkyū-buntansha): 池田 公英 熊本大学, 医学部附属病院, 助教 (20448525) ; 鈴木 実 熊本大学, 大学院生命科学研究部(医), 教授 (80312940)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 多発肺腺癌 / エストロゲン / エスロトゲン / アロマターゼ / CYP19A1 / 肺腺癌

Outline of Final Research Achievements

In this study, we quantitated estrogen concentration in the peripheral lungs of postmenopausal female patients with synchronous multiple lung adenocarcinomas SMLA.　The tissue concentration of estrogens (estrone [E1] and estdadiol [E2]) in the noncancerous peripheral lung were measured with liquid chromatography/electrospray tandem mass spectrometry in postmenopausal female patients with lung adenocarcinoma. The concentrations of E1 and E2 in the noncancerous tissue were significantly higher in SMLA cases than control cases. The minor allele (A) of single nucleotide polymorphism rs3764221 were significantly associated with higher concentration of E1 and E2 and higher CYP19A1 mRNA expression.
The tissue estrogen concentration of peripheral lung was significantly higher in SMLA than control cases. The high concentration of estrogen may be one of the causes of multicentric development of peripheral lung adenocarcinomas.

Research Products

• [Journal Article] Synchronous Multiple Lung Adenocarcinomas: Estrogen Concentration in Peripheral Lung. (2016)
  • Author(s): Koei Ikeda
  • Journal Title: PLoS One Volume: １１
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 閉経後女性における多発肺腺癌の発生とエストロゲン代謝の関連性の検討 (2016)
  • Author(s): 池田公英
  • Organizer: 第33回日本呼吸器外科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2016-05-12
• [Presentation] 肺癌切除症例の背景肺におけるエストロゲン濃度の検討 (2015)
  • Author(s): 池田公英
  • Organizer: 日本肺癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2015-11-26