Ameliorating bronchiolitis oblietrans after transplantation using hemoglobin vesicles by controlling ADAM/MMP expressions.
| Project/Area Number |
26462134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Keio University |
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Principal Investigator |
Ohtsuka Takashi 慶應義塾大学, 医学部(信濃町), 准教授 (40306717)
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| Co-Investigator(Kenkyū-buntansha) |
下田 将之 慶應義塾大学, 医学部(信濃町), 講師 (70383734)
安樂 真樹 東京大学, 医学部附属病院, 特任准教授 (70598557)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肺移植 / 拒絶反応 / メタロプロテアーゼ / マトリックスメタロプロテアーゼ / 肺移植拒絶反応 |
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| Outline of Final Research Achievements |
Acute rejection after lung transplantation is the main risk factor for the development of bronchiolitis obliterans (BO). We investigated inhibitor of Matrix metalloproteinases (MMPs) could ameliorate acute rejection in mouse trachea transplantation model. MMP inhibitor was given to the transplanted mice. The acute rejection of tracheal transplant was decreased in the allograft treated with MMP inhibitor. Regulatory T-cell infiltration and IL-10 mRNA expression increased in the allograft treated with MMP inhibitor. MMP inhibitor could be the treatment option for BO after lung transplantation.
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Report
(4 results)
Research Products
(2 results)
