The roles of cancer stem cells and driver genes for clarifying the mechanism of lung cancer from COPD

• Project/Area Number: 26462139
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: SEKINE YASUO 東京女子医科大学, 医学部, 教授 (70312957)
• Co-Investigator(Kenkyū-buntansha): 黄 英哲 東京女子医科大学, 医学部, 准講師 (40375689) ; 廣島 健三 東京女子医科大学, 医学部, 教授 (80218833)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 肺癌 / 扁平上皮癌 / 遺伝子多型 / PD-L1 / 肺気腫合併肺線維症 / Driver gene

Outline of Final Research Achievements

It has been reported that squamous cell carcinoma (SCC) has many polymorphisms and that expression of PD-L1 is frequently observed. SCC is highly observed in patients with COPD. We investigated the relationship between SCC and many types of cancer-related genes by immunohistochemistry (IHC). IHC (p65, PTEN, p16, PI3K, FGFR1) has been done for 50 cases of SCC. SCC patients with COPD (25 cases) tended to express PTEN and FGFR1 more strongly than non-COPD patients. Currently we investigate expression of PD-L1 for SCC.

Research Products

• [Journal Article] Impact of combined pulmonary fibrosis and emphysema on surgical complications and long-term survivals in patients undergoing surgery for non-small cell lung cancer (2016)
  • Author(s): Hata A, Sekine Y, Ohashi K, Koh E, Yoshino I
  • Journal Title: Int J COPD Volume: 11 Pages: 1261-1268
  • DOI: 10.2147/copd.s94119
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cytologic Differential Diagnosis of Malignant Mesothelioma and Reactive Mesothelial Cells With FISH Analysis of p16 (2016)
  • Author(s): Hiroshima K, Wu D, Hasegawa M, Koh E, Sekine Y, Ozaki D, Yusa T, Walts AE, Marchevsky AM, Nabeshima K, Tada Y, Shimada H, Tagawa M
  • Journal Title: Diagn Cytopathol Volume: 44 Issue: 7 Pages: 591-598
  • DOI: 10.1002/dc.23490
  • Peer Reviewed
• [Journal Article] Preoperative exercise testing is a better predictor of postoperative complications than pulmonary function testing for patients with lung cancer (2015)
  • Author(s): Hata A, Sekine Y, Koh E, Yamaguchi N
  • Journal Title: Open J Thorac Surg. Volume: 5 Issue: 01 Pages: 15-20
  • DOI: 10.4236/ojts.2015.51004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] COPDの肺癌合併 (2015)
  • Author(s): 関根康雄
  • Journal Title: 診断と治療 Volume: 103 Pages: 475-480
• [Journal Article] Detection of chronic obstructive pulmonary disease in community-based annual lung cancer screening: Chiba COPD lung cancer screening study group (2014)
  • Author(s): Sekine Y, Fujisawa T, Suzuki K, Tsutatani S, Kubota K, Ikegami H, Isobe Y, Nakamura M, Takiguchi, Y, Tatsumi K
  • Journal Title: Respirology Volume: 19 Issue: 1 Pages: 98-104
  • DOI: 10.1111/resp.12179
  • Peer Reviewed
• [Journal Article] The impact of combined pulmonary fibrosis and chronic obstructive pulmonary disease on long-term survival after lung cancer surgery (2014)
  • Author(s): Sekine Y, Sakairi Y, Yoshino M, Koh E, Hata A, Suzuki H, Yoshino I
  • Journal Title: Thorac Cardiovasc Surg Volume: (in press) Issue: 04 Pages: 332-337
  • DOI: 10.1055/s-0033-1363478
  • NAID: 130003366327
  • Peer Reviewed
• [Journal Article] Surveillance of chronic obstructive pulmonary disease in high-risk individuals by using regional lung-cancer mass screenin (2014)
  • Author(s): Sekine Y, Yanagihori R, Suzuki K, Sugiyama S, Yamaji H, Ishibashi M, Fujisawa T
  • Journal Title: Int J COPD Volume: 9 Pages: 647-656
  • DOI: 10.2147/copd.s62053
  • Peer Reviewed / Open Access
• [Journal Article] Lung carcinogenesis from chronic obstructive pulmonary disease: characteristics of lung cancer from COPD and contribution of signal transducers and lung stem cells in the inflammatory microenvironment. (2014)
  • Author(s): Sekine Y, Hata A, Koh E, Hiroshima K.
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 62 Issue: 7 Pages: 415-421
  • DOI: 10.1007/s11748-014-0386-x
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] The Efficacy of Lung Volume Analyzer for Measuring Resection Margin in Pulmonary Segmentectomy for Malignant Diseases (2016)
  • Author(s): Sekine Y, Yun T, Toyoda T, Kaiho D, Koh E, Kamata T.
  • Organizer: World Congress on Lung Cancer 2016
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] 手術における画像支援（3D画像など）Volume Analyzer synapse (2016)
  • Author(s): 関根康雄、海寳大輔、豊田行英、尹 貴正、黄英哲、鎌田稔子、飯田智彦
  • Organizer: 第33回日本呼吸器外科学会総会
  • Place of Presentation: 京都国際会議場，京都
  • Year and Date: 2016-05-12
• [Presentation] 肺区域切除VINCENTとICGの気管支注入および近赤外線胸腔鏡 (2016)
  • Author(s): 関根康雄、豊田行英、海寳大輔、尹 貴正、黄英哲、鎌田稔子、飯田智彦
  • Organizer: 第33回日本呼吸器外科学会総会
  • Place of Presentation: 京都国際会議場，京都
  • Year and Date: 2016-05-12
• [Presentation] 合併症を有する肺がんに対する外科的治療戦略 CPFE合併肺がんの外科治療成績 (2015)
  • Author(s): 関根康雄
  • Organizer: 第56回日本肺癌学会総会
  • Place of Presentation: 横浜，横浜国際会議場
  • Year and Date: 2015-11-26
  • Invited
• [Presentation] A preliminary study on detection of chronic obstructive pulmonary disease and lung cancer by using regional lung cancer mass screening (2015)
  • Author(s): Fujisawa T, Sekine Y, Yanagibori R, Suzuki K, Yamaji H, Tokuda A, Sugiyama S
  • Organizer: International Association for Study of Lung Cancer Sydney
  • Place of Presentation: Denver, USA
  • Year and Date: 2015-09-06
  • Int'l Joint Research
• [Presentation] Impact of Combined Pulmonary Fibrosis and Emphysema on surgical complication and long-term survival of patients undergoing surgery for non-small cell lung cancer (2015)
  • Author(s): Hata A, Sekine Y, Koh E, Yoshino I
  • Organizer: 23rd annual meeting of European Society of Thoracic Surgeon
  • Place of Presentation: Lisbon Prtugie, 2015
  • Year and Date: 2015-05-29
  • Int'l Joint Research
• [Presentation] Video ICG-guided segmentectomy (2015)
  • Author(s): Sekine Y
  • Organizer: 95th Annual Meeting of the American Association for Thoracic Surgery
  • Place of Presentation: Seattle, USA
  • Year and Date: 2015-04-24
  • Int'l Joint Research / Invited
• [Presentation] 肺線維症・CPFEが予後に与えるインパクト (2015)
  • Author(s): 関根康雄
  • Organizer: 第55回日本呼吸器学会
  • Place of Presentation: 東京，東京国際フォーラム
  • Year and Date: 2015-04-14
  • Invited
• [Presentation] Preoperative exercise test is more predictive for postopearative complications than pulmonary function test for lung cancer (2014)
  • Author(s): Sekine Y, Hata A, Koh E
  • Organizer: Asian-Pacific Lung Cancer Conference
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2014-11-06 – 2014-11-08
• [Book] 肺がん治療における医療経済の評価法第８章 疾患領域ごとの医療経済評価の評価法と活用すべきデータの選択 (2015)
  • Author(s): 関根康雄
  • Total Pages: 7
  • Publisher: 技術情報協会