The roles of cancer stem cells and driver genes for clarifying the mechanism of lung cancer from COPD
Project/Area Number |
26462139
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory surgery
|
Research Institution | Tokyo Women's Medical University |
Principal Investigator |
SEKINE YASUO 東京女子医科大学, 医学部, 教授 (70312957)
|
Co-Investigator(Kenkyū-buntansha) |
黄 英哲 東京女子医科大学, 医学部, 准講師 (40375689)
廣島 健三 東京女子医科大学, 医学部, 教授 (80218833)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 肺癌 / 扁平上皮癌 / 遺伝子多型 / PD-L1 / 肺気腫合併肺線維症 / Driver gene |
Outline of Final Research Achievements |
It has been reported that squamous cell carcinoma (SCC) has many polymorphisms and that expression of PD-L1 is frequently observed. SCC is highly observed in patients with COPD. We investigated the relationship between SCC and many types of cancer-related genes by immunohistochemistry (IHC). IHC (p65, PTEN, p16, PI3K, FGFR1) has been done for 50 cases of SCC. SCC patients with COPD (25 cases) tended to express PTEN and FGFR1 more strongly than non-COPD patients. Currently we investigate expression of PD-L1 for SCC.
|
Report
(4 results)
Research Products
(18 results)
-
-
[Journal Article] Cytologic Differential Diagnosis of Malignant Mesothelioma and Reactive Mesothelial Cells With FISH Analysis of p162016
Author(s)
Hiroshima K, Wu D, Hasegawa M, Koh E, Sekine Y, Ozaki D, Yusa T, Walts AE, Marchevsky AM, Nabeshima K, Tada Y, Shimada H, Tagawa M
-
Journal Title
Diagn Cytopathol
Volume: 44
Issue: 7
Pages: 591-598
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Detection of chronic obstructive pulmonary disease in community-based annual lung cancer screening: Chiba COPD lung cancer screening study group2014
Author(s)
Sekine Y, Fujisawa T, Suzuki K, Tsutatani S, Kubota K, Ikegami H, Isobe Y, Nakamura M, Takiguchi, Y, Tatsumi K
-
Journal Title
Respirology
Volume: 19
Issue: 1
Pages: 98-104
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-