| Project/Area Number |
26462142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
MORIYA Yasumitsu 千葉県がんセンター(研究所), がんゲノムセンター, 客員研究員 (90375692)
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| Co-Investigator(Kenkyū-buntansha) |
飯笹 俊彦 千葉県がんセンター(研究所), 医療局, 医療局長 (10272303)
横井 左奈 千葉県がんセンター(研究所), がんゲノムセンター, 部長 (30372452)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肺癌 / ゲノム / マイクロRNA / 遺伝子 / 外科 / 喫煙関連肺癌 / 扁平上皮癌 / 喫煙関連肺癌ｎ / マイクロＲＮＡ |
|---|
| Outline of Final Research Achievements |
Squamous cell carcinoma (SqCC) is second major histological subtype of lung cancer. Unlike in the case of lung adenocarcinoma (Ad), SqCC has only few molecular target drugs. In the mature microRNA(miR) fragments, 34 miRs were identified as the candidates especially for SqCC distinguished from Ad. Furthermore, four miRs were up regulated in amplified regions and independently associated with poor prognosis in SqCC. Moreover, those who had the tumor with high expression in three of four miRs simultaneously showed the worst prognosis. To explore miR-mRNA network, we also predicted the target genes for each miRs. MicroRNA will regulate target molecules related to carcinogenesis and malignancy in SqCC.
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