| Project/Area Number |
26462146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
片野 光男 九州大学, 医学研究院, 教授 (10145203)
大西 秀哉 九州大学, 医学研究院, 准教授 (30553276)
中野 賢二 九州大学, 先端融合医療レドックスナビ研究拠点, 教授 (00315061)
小田 義直 九州大学, 医学研究院, 教授 (70291515)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 胸腺癌 / TrkB / BDNF / 増殖能 / 浸潤能 / 治療標的 / 胸腺癌増殖能 / 腫瘍形成能 / 診断マーカー / ＢＤＮＦ / 増殖 / 浸潤 / 予後予測因子 / 浸潤性胸腺腫 |
|---|
| Outline of Final Research Achievements |
In the analysis of TrkB expression using surgically resected specimen, only 1 case out of 48 cases was positive for TrkB in benign thymoma. However, all 5 cases were positive for TrkB in thymic cancer. It suggests that TrkB expression could be a diagnostic marker for thymic cancer. In the experiment using thymic cancer cell line, Ty-82, TrkB/BDNF signaling pathway contributed to proliferation and tumorigenesis. Therefore, TrkB/BDNF signaling pathway could be a new therapeutic target for thymic cancer.
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