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The cytostatic effects of zoledronic acid on ACC-MESO-1 cells

Research Project

Project/Area Number 26462148
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionKeio University

Principal Investigator

Asakura Keisuke  慶應義塾大学, 医学部(信濃町), 共同研究員 (90383786)

Co-Investigator(Kenkyū-buntansha) 河野 光智  東海大学, 医学部, 准教授 (10276272)
大塚 崇  慶應義塾大学, 医学部(信濃町), 准教授 (40306717)
涌井 昌俊  慶應義塾大学, 医学部(信濃町), 講師 (90240465)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords悪性胸膜中皮腫 / ゾレドロン酸 / ビスフォスフォネート / オートファジー
Outline of Final Research Achievements

Malignant pleural mesothelioma is widely resistant to therapies, and new treatment starategies are needed. We clarified that zoledronic acid reduces cell viavility and cell migration of human malignant pleural mesothelioma cells in vitro, and that induction of autophagic changes may at least in part be involved in this process.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] 高脂血症治療薬ロバスタチンのヒト悪性胸膜中皮腫細胞株に対するオート ファジー誘導を介した抗腫瘍効果2015

    • Author(s)
      朝倉 啓介
    • Organizer
      日本肺癌学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-11-27
    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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