The cytostatic effects of zoledronic acid on ACC-MESO-1 cells

Research Project

Project/Area Number	26462148
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Respiratory surgery
Research Institution	Keio University
Principal Investigator	Asakura Keisuke 慶應義塾大学, 医学部(信濃町), 共同研究員 (90383786)
Co-Investigator(Kenkyū-buntansha)	河野光智東海大学, 医学部, 准教授 (10276272) 大塚崇慶應義塾大学, 医学部(信濃町), 准教授 (40306717) 涌井昌俊慶應義塾大学, 医学部(信濃町), 講師 (90240465)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	悪性胸膜中皮腫 / ゾレドロン酸 / ビスフォスフォネート / オートファジー
Outline of Final Research Achievements	Malignant pleural mesothelioma is widely resistant to therapies, and new treatment starategies are needed. We clarified that zoledronic acid reduces cell viavility and cell migration of human malignant pleural mesothelioma cells in vitro, and that induction of autophagic changes may at least in part be involved in this process.