| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
To establish the animal model of dural arteriovenous fistula, mouse model of chronic cerebral ischemia was created by common carotid artery stenosis using external microcoils with inner diameter of 0.2 mm or less. The changes of cerebral blood flow in the cerebral cortex were measured by laser-Doppler flowmetry for 30 days after common carotid artery stenosis. The CBF values decreased to about 35% immediately after carotid stenosis, however, the CBF recovered to about 70% of baseline at 30 days. Histological analysis revealed selective detachment of neurons at the hippocampal CA1 region and myelin degeneration at the white matter of corpus callosum.
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