| Project/Area Number |
26462153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | University of Toyama |
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Principal Investigator |
KUWAYAMA Naoya 富山大学, 大学院医学薬学研究部(医学), 准教授 (30178157)
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| Co-Investigator(Kenkyū-buntansha) |
秋岡 直樹 富山大学, 附属病院, 助教 (70422631)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 脳血管障害 / 高次脳機能 / 頚動脈狭窄症 / 認知機能低下 / 頚動脈ステント留置術 / 脳梗塞 / 脳血管障害学 |
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| Outline of Final Research Achievements |
The cognitive impairment was analyzed in 105 patients (mean age: 70.6 years) with asymptomatic carotid artery stenosis (mean rate: 81.8%). The WAIS-R2 subtests and JART did not reveal the cognitive impairment in these patients, however the discrepancy analysis between the RBANS and the WAIS-R subtests/JART clearly demonstrated the significant decline in at least one RBANS domain (immediate memory, visuospatial/construction, language, attention, delayed memory and total score) in more than 90% of the patients. Sixty of these 105 patients underwent carotid artery stenting. The postoperative RBANS scores improved in all domains in all 60 patients. The analysis of the Fazekas classification suggested that the deep white matter lesions would be the important factor to predict the postoperative improvement of the impaired cognitive function.
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