Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Outline of Final Research Achievements |
We investigated the relaxant effects of β-adrenoceptor agonist on isolated rabbit basilar artery. As a result, β-adrenoceptor agonists including ritodrine hydrochloride dose-dependently relaxed on KCl-induced contraction of rabbit basilar artery. Thereafter, we examined the messenger RNAs (mRNAs) expression of β-adorenoceptor on rabbit, dog and human basilar artery. The mRNA of β1 and β2- adrenoceptor were detected on these basilar arteries .The in vivo pharmacological properties were tested, the effect of ritodrine hydrochloride on subarachnoid hemorrhage - induced cerebral vasospasm dog model. However, ritodrine hydrochloride did not improve this vasospasm.
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