| Project/Area Number |
26462160
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
河北 賢哉 香川大学, 医学部附属病院, 准教授 (10505803)
河井 信行 香川大学, 医学部, 准教授 (40294756)
小川 大輔 香川大学, 医学部附属病院, 病院助教 (70524057)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | microRNA / MiR-451 / brain trauma / 重症脳外傷 / 髄液採取 / くも膜下出血 / 脳低温療法 / S100B / 脳脊髄液 / ELISA |
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| Outline of Final Research Achievements |
We investigated that miRNA expression patterns and levels in plasma and cerebrospinal fluid are different from those of non-brain trauma patients and examined the possibility that their expression may be a prognostic factor or a biomarker. Plasma of head injured patients was measured with microRNA microarray, and as a result, there were three types with high absolute expression amount, miR-451, miR 223 and miR-16. Regarding the changes in microRNA in the cerebrospinal fluid, the expression levels of miR-451a, miR-21, and miR-16 were three types. MiR-451 was expressed most in all microRNAs. Further studies are needed to determine whether these microRNAs will become biomarkers of brain trauma from now on.
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