| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Brain microvasular pericytes plays a pivotal role in blood-brain barrier (BBB) maintenance. We did not succeed in developing spontaneous intracerebral hemorrhage model through angiotensin II-mediated hypertension in aged mice with overexpression of Nox4, an enzyme producing reactive oxygen species, in pericytes. However, we found that 1) Nox4 expression was upregulted through angiotensin II stimulus in cultured brain pericytes, and that 2) Nox4 overexpression in cultured brain pericytes upregulated expression and activity of NFkB and MMP-9, both of which are highly associated with BBB breakdown. Our results may indicate that Nox4 upregulation in brain pericytes could be one of possible mechanism for hypertensive ntracerebral hemorrhage.
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