Pathogenic mechanism of spontaneous hypertensive intracerebral hemorrhage focused on ROS-producing enzyme Nox4 expressed in brain microvascular pericytes
| Project/Area Number |
26462163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
AGO Tetsuro 九州大学, 大学病院, 講師 (30514202)
KURODA Junya 九州大学, 大学病院, 助教 (70614858)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 脳出血 / 脳卒中 / 高血圧 / 酸化ストレス / 高血圧性脳出血 / 脳血管周皮細胞 / 活性酸素生成酵素種 / アンギオテンシン |
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| Outline of Final Research Achievements |
Brain microvasular pericytes plays a pivotal role in blood-brain barrier (BBB) maintenance. We did not succeed in developing spontaneous intracerebral hemorrhage model through angiotensin II-mediated hypertension in aged mice with overexpression of Nox4, an enzyme producing reactive oxygen species, in pericytes. However, we found that 1) Nox4 expression was upregulted through angiotensin II stimulus in cultured brain pericytes, and that 2) Nox4 overexpression in cultured brain pericytes upregulated expression and activity of NFkB and MMP-9, both of which are highly associated with BBB breakdown. Our results may indicate that Nox4 upregulation in brain pericytes could be one of possible mechanism for hypertensive ntracerebral hemorrhage.
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Report
(5 results)
Research Products
(34 results)
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[Journal Article] Influence of Statin Pretreatment on Initial Neurological Severity and Short-Term Functional Outcome in Acute Ischemic Stroke Patients: The Fukuoka Stroke Registry2016
Author(s)
Hiromi Ishikawa, Yoshinobu Wakisaka, Ryu Matsuo, Noriko Makihara, Jun Hata, Junya Kuroda, Tetsuro Ago, Jiro Kitayama, Hiroshi Nakane, Masahiro Kamouchi, Takanari Kitazono, Fukuoka Stroke Registry Investigators
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Journal Title
Cerebrovasc Dis
Volume: 42
Issue: 5-6
Pages: 395-403
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Possible involvement of basic FGF in the upregulation of PDGFRβ in pericytes after ischemic stroke2016
Author(s)
Nakamura K, Arimura K, Nishimura A, Tachibana M, Yoshikawa Y, Makihara N, Wakisaka Y, Kuroda J, Kamouchi M, Ooboshi H, Kitazono T, Ago T
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Journal Title
Brain Research
Volume: 1630
Pages: 98-108
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke2015
Author(s)
Makihara N, Arimura K, Ago T, Tachibana M, Nishimura A, Nakamura K, Matsuo R, Wakisaka Y, Kuroda J, Sugimori H, Kamouchi M, Kitazono T
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Journal Title
Experimental Neurology
Volume: 264
Pages: 127-134
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke.2014
Author(s)
Wakisaka Y, Ago T, Kamouchi M, Kuroda J, Matsuo R, Hata J, Gotoh S, Isomura T, Awano H, Suzuki K, Fukuda K, Okada Y, Kiyohara Y, Ooboshi H, Kitazono T; REBIOS Investigators.
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Journal Title
J Neurol Sci
Volume: 340
Issue: 1-2
Pages: 75-9
DOI
Related Report
Peer Reviewed
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