| Project/Area Number |
26462165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
HORIE Nobutaka 長崎大学, 病院(医学系), 助教 (70380912)
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| Co-Investigator(Kenkyū-buntansha) |
日宇 健 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (00404260)
西田 教行 長崎大学, 医歯薬学総合研究科(医学系), 教授 (40333520)
佐藤 克也 長崎大学, 医歯薬学総合研究科(保健学科), 教授 (70398147)
山口 将 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (70712131)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳梗塞 / 幹細胞 / 移植 / 再生医療 / 低酸素 |
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| Outline of Final Research Achievements |
Intra-arterial cell transplantation provides timing-dependent cell distribution and post-stroke functional recovery via a combination of neuroprotection, reactive astrocyte enhancement and angiogenesis.At day 8 post-stroke, microglia activation was suppressed significantly, and interleukin (IL)-1β and IL-12p70 were reduced in both groups. Although high-dose MSCs were more widely distributed in the cortex and striatum of rats, the degree of intravascular cell aggregation and mortality was significantly higher in the high-dose group. Aging of hMSC may be a critical factor that affects cell therapy outcomes, and transplantation of young hMSC appears to provide better functional recovery through anti-inflammation effects, vessel maturation, and neurogenesis potentially due to the dominance of trophic factor secretion.
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