| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We have been conducting transplantation experiments on neural cells differentiated from human iPS cells to hemiplegic model mice.Reelin was identified as a protein that controls neuronal cell migration and layered structure formation of the motor cortex during development of humans.In our experimental system, inflammatory cells and transplanted cells in the brain both produced Reelin.The transplanted neural cells expressed receptors of Reelin. After binding of Reelin to its receptors they migrated to the injured cortex where the neural network was then reconstructed. The grafted neural stem / progenitor cells that migrated to the injured cortex were accompanied by their differentiation into the cortical motor neurons during the migration. In the neural cell transplantation to hemiplegic model animal, Reelin was shown to be important for histological repair and function recovery.
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