| Project/Area Number |
26462175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Yamagata University (2015-2016)
Tohoku University (2014) |
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Principal Investigator |
SONODA YUKIHIKO 山形大学, 大学院医学系研究科, 教授 (90302140)
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| Co-Investigator(Kenkyū-buntansha) |
齋藤 竜太 東北大学, 大学病院, 助教 (10400243)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 膠芽腫 / 腫瘍幹細胞 / CED / glioma / stem cell / 幹細胞 / グリオーマ / AICAR |
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| Outline of Final Research Achievements |
We cultured glioma stem cell and added AICAR which acts differentiation of stem cells.
As results, differentiation of gliomas with minimal toxicity was observed. In vivo study, we injected AICAR into normal mice brain by CED methods. No severe toxicity was observed in mice brain. Finally we created mouse brain tumor model by implantation of glioma stem cell, then treated with AICAR by CED. Unfortunately, no survival benefit was observed in treated group compared with control group. In conclusion, AICAR was strong effect for differentiation of glioma stem cell, however inhibition of cell growth was modest.
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