Functional role and contribution to angiogenesis of WT1 /ALCAM molecules in glioma stem cell
Project/Area Number |
26462180
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | Kyoto Prefectural University of Medicine (2015-2016) Osaka University (2014) |
Principal Investigator |
Hashimoto Naoya 京都府立医科大学, 医学(系)研究科(研究院), 教授 (90315945)
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Co-Investigator(Kenkyū-buntansha) |
坪井 昭博 大阪大学, 医学系研究科, 寄附講座教授 (10372608)
千葉 泰良 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, 脳神経外科・医長 (90533795)
永野 大輔 大阪大学, 医学部附属病院, 医員 (70726520)
高野 浩司 大阪大学, 医学系研究科, 招へい教員 (90649203)
福屋 章悟 大阪大学, 医学部附属病院, 医員 (50726502)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | ALCAM/sALCAM / WT1 / glioma stem cell / tumor formation / angiogenesis / tumor invasion / 腫瘍血管新生能 / 腫瘍形成能 |
Outline of Final Research Achievements |
Through a series of experimental procedure on ALCAM (Activated leukocyte cell adhesion molecule) and WT1 (Wilms’ Tumor 1) molecules using glioma stem cell and glioma cell, we found that WT1 plays an important role for tumor formation capability in those cells, and that both molecules are essential for tumor angiogenesis. Also, we revealed that sALCAM (soluble ALCAM) could relate to tumor-angiogenesis and tumor invasion ability.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Direct microsurgical embolectomy for acute occlusion of the internal carotid artery and middle cerebral artery.2016
Author(s)
Hino A, Oka H, Hashimoto Y, Echigo T, Koseki H, Fujii A, Katsumori T, ShiomiN, Nozaki K, Arima H, Hashimoto N.
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Journal Title
World Neurosurg
Volume: 88
Pages: 243-251
DOI
Related Report
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[Journal Article] Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.2016
Author(s)
Thompson EM, Hielscher T, Bouffet E, Remke M, Luu B, Kagawa N, Hashimoto N, Jabado N, Shih DJ, Kijima N, Northcott PA, Kool M, Jones DT, Chan JA, Hawkins CE, Tabori U, Drake J, Kulkarni A, Dirks P, Rutka JT, Korshunov A, Pfister SM, Packer RJ, Ramaswamy V, Taylor MD.
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Journal Title
Lancet Oncol.
Volume: 17(4)
Issue: 4
Pages: 484-495
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Immunotherapy response assessment in neuro-oncology: a report of the RANO working group.2015
Author(s)
Okada H, Weller M, Huang R, Finocchiaro G, Gilbert MR, Wick W, Ellingson BM, Hashimoto N, Pollack IF, Brandes AA, Franceschi E, Herold-Mende C, Nayak L, Panigrahy A, Pope WB, Prins R, Sampson JH, Wen PY, Reardon DA.
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Journal Title
Lancet Oncol.
Volume: 16
Issue: 15
Pages: e534-e542
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response2015
Author(s)
Naoya Hashimoto, Akihiro Tsuboi, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Manabu Kinoshita, Noriyuki Kijima, Yoshihiro Oka, Soyoko Morimoto, Hiroko Nakajima, Satoshi Morita, Junichi Sakamoto, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Norio Arita, Toshiki Yoshimine, Haruo Sugiyama
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Journal Title
Cancer Immunology Immunotherapy
Volume: -
Issue: 6
Pages: 707-16
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] 2.Different spatial distribution between germinal center B and non-germinal center B primary central nervous system lymphoma revealed by magnetic resonance group analysis.2014
Author(s)
Kinoshita M1, Sasayama T, Narita Y, Yamashita F, Kawaguchi A, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohno M, Miyakita Y, Shibui S, Hashimoto N, Yoshimine T
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Journal Title
Neuro Oncol
Volume: 16
Issue: 5
Pages: 728-734
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 神経膠腫に対するWT1ペプチドワクチン療法の新展開2015
Author(s)
橋本直哉, 坪井昭博, 香川尚己, 千葉泰良, 木下 学, 木嶋教行, 有田英之, 平山龍一, 永野大輔, 高野浩二, 福屋章悟, 福永貴典, 岡 芳弘, 尾路祐介, 杉山治夫,吉峰俊樹
Organizer
第74回日本脳神経外科学会総会
Place of Presentation
札幌
Year and Date
2015-10-14
Related Report
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[Presentation] 悪性グリオーマに対するWT1 CTL ペプチドとWT1 ヘルパーペプチドを併用した免疫療法2014
Author(s)
橋本直哉, 坪井昭博, 香川尚己, 福屋章悟, 永野大輔, 高野浩司, 平山龍一, 有田英之, 千葉泰良, 木下学, 森本創世子, 岡芳弘, 尾路祐介, 杉山治夫, 吉峰俊樹.
Organizer
第32回日本脳腫瘍学会学術集会
Place of Presentation
シェラトン・グランデ・トーキョーベイ・ホテル(千葉県浦安市)
Year and Date
2014-11-30
Related Report
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[Presentation] 髄芽腫の再発予測と治療戦略における分子亜型分類の意義2014
Author(s)
香川 尚己, 平山 龍一, 木嶋 教行, 千葉 泰良, 有田 英之, 木下 学, 高野 浩司,永野 大輔, 福屋 章悟, 山本 福子, 金村 米博, 橋井 佳子, 原 純一, 橋本 直哉,吉峰 俊樹
Organizer
日本脳神経外科学会 第73回学術総会
Place of Presentation
グランドプリンスホテル新高輪(東京都港区)
Year and Date
2014-10-10
Related Report
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[Presentation] WT1 peptide vaccination for malignant gliomas as a part of multi-modal therapy2014
Author(s)
Naoya Hashimoto, Akihiro Tuboi, Yasuyoshi Chiba, Ryuichi Hirayama, Koji Takano, Noriyuki Kijima, Yoshihiro Oka, Naoki Kagawa, Shuichi Izumoto, Haruo Sugiyama, Toshiki Yoshimine
Organizer
ICBTRT2014_20th International Conference on Brain Tumor Research and Therapy
Place of Presentation
California, USA
Year and Date
2014-07-22
Related Report
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[Presentation] RESPONSEASSESSMENTS IN WT1 PEPTIDE VACCINATION AND LONG TERM RESULTS OF COMOZOLOMIDE THERAPY2014
Author(s)
Naoya Hashimoto,Akihiro Tsuboi,Yasuyoshi Chiba,Yoshihiro Oka,Soyoko Morimoto,Hiroko Nakajima,Sumiyuki Nishida,Naoki Hosen,Naoki Kagawa,Yusuke Oji,Toshiki Yoshimine,Haruo Sugiyama
Organizer
The7th International Conference on WT1 in human neoplasia
Place of Presentation
Barcelona, Spain
Year and Date
2014-04-23
Related Report
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