| Project/Area Number |
26462180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kyoto Prefectural University of Medicine (2015-2016)
Osaka University (2014) |
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Principal Investigator |
Hashimoto Naoya 京都府立医科大学, 医学(系)研究科(研究院), 教授 (90315945)
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| Co-Investigator(Kenkyū-buntansha) |
坪井 昭博 大阪大学, 医学系研究科, 寄附講座教授 (10372608)
千葉 泰良 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, 脳神経外科・医長 (90533795)
永野 大輔 大阪大学, 医学部附属病院, 医員 (70726520)
高野 浩司 大阪大学, 医学系研究科, 招へい教員 (90649203)
福屋 章悟 大阪大学, 医学部附属病院, 医員 (50726502)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ALCAM/sALCAM / WT1 / glioma stem cell / tumor formation / angiogenesis / tumor invasion / 腫瘍血管新生能 / 腫瘍形成能 |
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| Outline of Final Research Achievements |
Through a series of experimental procedure on ALCAM (Activated leukocyte cell adhesion molecule) and WT1 (Wilms’ Tumor 1) molecules using glioma stem cell and glioma cell, we found that WT1 plays an important role for tumor formation capability in those cells, and that both molecules are essential for tumor angiogenesis. Also, we revealed that sALCAM (soluble ALCAM) could relate to tumor-angiogenesis and tumor invasion ability.
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