Analysis of glioblastoma pathogenesis based on transcriptome analysis
| Project/Area Number |
26462185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
村上 信哉 九州大学, 医学研究院, 共同研究員 (20553283)
溝口 昌弘 九州大学, 医学研究院, 共同研究員 (50380621)
天野 敏之 九州大学, 医学研究院, 共同研究員 (70448413)
飯原 弘二 九州大学, 医学研究院, 教授 (90270727)
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| Research Collaborator |
MURATA Hideki
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Glioblastoma / Mesenchymal / HDAC7 / 膠芽腫 / 間葉系 / mesenchymal / glioblastoma / proneural |
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| Outline of Final Research Achievements |
We evaluated the correlation between the MES score and expression of HDAC and histone demethylase genes and found that the MES score correlated only with HDAC7 expression (correlation coefficient 0.5165; p < 0.0001). To determine HDAC7 protein expression in GBM tissues, we selected and immunostained 10 GBM tissues with high MES scores (>6) and 11 with low MES scores (<2) by using a cutoff of the mean ± SD of the MES score. Immunohistochemical results demonstrated a higher positive immunostaining in the high MES score group than in the low MES score group (Mann-Whitney test, p = 0.0002).We showed that mesenchymal gene expression in glioblastoma is associated with HDAC7 gene and protein expression; thus, HDAC7 might be a novel therapeutic target for glioblastoma.
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Report
(4 results)
Research Products
(7 results)
