Deep sequence analysis of treatment resistance in glioblastoma
| Project/Area Number |
26462186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
HIDE Takuichiro 熊本大学, 医学部附属病院, 診療講師 (40421820)
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| Co-Investigator(Kenkyū-buntansha) |
牧野 敬史 熊本大学, 医学部附属病院, 講師 (90381011)
中村 英夫 熊本大学, 医学部附属病院, 講師 (30359963)
矢野 茂敏 熊本大学, 大学院生命科学研究部(医), 准教授 (60332871)
倉津 純一 熊本大学, 大学院生命科学研究部(医), 教授 (20145296)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膠芽腫 / ディープシークエンス / 治療抵抗性 / 再発 / 視床膠芽腫 / 尾状核膠芽腫 / 新規治療 |
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| Outline of Final Research Achievements |
To identify gene mutations on treatment resistance and recurrence, deep sequence analysis was done. Comparing to primary tumor, mutations were generally accumulate in recurrent tumor, however, some mutations were disappeared in recurrent tumors. These results suggested that recurrent tumors were not always same to primary tumors. This spatio-temporal heterogeneity is regarded as the cause of resistance for chemo-radiotherapy and recurrence of glioblastoma.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Novel metal chelating molecules with anticancer activity. Striking effect of the imidazole substitution of the histidine-pyridine-histidine system2015
Author(s)
Ali, Taha F. S.; Iwamaru, Kana; Ciftci, Halil Ibrahim; Koga, Ryoko; Matsumoto, Masahiro; Oba, Yasunori; Kurosaki, Hiromasa; Fujita, Mikako; Okamoto, Yoshinari; Otsuka, Masami et. al.
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Journal Title
Bioorganic & Medicinal Chemistry
Volume: 23
Issue: 17
Pages: 5476-5482
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The anti-tumor effect of fibrin glue containing temozolomide against malignant glioma2014
Author(s)
Anai, S, Hide T, Takezaki T, Kuroda J, Shinojima, N, Makino K, Nakamura H, Yano S, Kuratsu J,
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Journal Title
Cancer Sci.
Volume: 105
Issue: 5
Pages: 583-591
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy.2014
Author(s)
Guo J, Shinriki S, Su Y, Nakamura T, Hayashi M, Tsuda Y, Murakami Y, Tasaki M, Hide T, Takezaki T, Kuratsu JI, Yamashita S, Ueda M, Li JD, Ando Y, Jono H
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Journal Title
Oncotarget
Volume: 5
Pages: 6353-6364
Related Report
Peer Reviewed
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