Regulation mechanism of intracellular trafficking of somatostatin receptor

• Project/Area Number: 26462190
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Teikyo University
• Principal Investigator: Matsuno Akira 帝京大学, 医学部, 教授 (00242058)
• Co-Investigator(Renkei-kenkyūsha): MIZUTANI AKIKO 帝京平成大学, 健康メディカル学部, 講師 (80465252) ; OSAMURA YOSHIYUKI 国際医療福祉大学, 大学院, 教授 (10100992)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 下垂体腺腫 / ソマトスタチン / 受容体 / GH

Outline of Final Research Achievements

Somatostatin receptor and gsp mutation were analyzed in 56 examples of GH production pituitary adenoma. The adenoma that has plasma membrane expression of somatostatin receptor has significantly more responsive to somatostatin analogues. In 45 examples of pituitary adenomas, expression of somatostatin receptor 2A and 5 was analyzed. GH producing adenomas have expression of both receptors in all samples, and 2 ACTH producing adenomas have expression of somatostatin receptor 5.

Research Products

• [Journal Article] Relationship between Silent Brain Infarction and Amount of Daily Coffee Consumption in Middle Age (2016)
  • Author(s): Nakaguchi H, Matsuno A, Okubo T, Hoya K
  • Journal Title: Journal of Stroke and Cerebrovascular Disease Volume: 25 Issue: 7 Pages: 1678
  • DOI: 10.1016/j.jstrokecerebrovasdis.2016.01.020
  • Peer Reviewed
• [Journal Article] 高ホモシステイン血症に合併した中大脳動脈狭窄症に対し経皮的脳血管形成術を施行した1例 (2016)
  • Author(s): 孫宰賢、松野彰
  • Journal Title: 脳卒中 Volume: 38 Pages: 98-103
  • Peer Reviewed
• [Journal Article] コイル塞栓術後、動脈瘤周囲浮腫を生じた一例 (2016)
  • Author(s): 孫宰賢、藤井教雄、松野彰
  • Journal Title: 脳卒中 Volume: 38 Pages: 120-124
  • Peer Reviewed
• [Journal Article] 動脈瘤を合併した下垂体腺腫の治療戦略 (2016)
  • Author(s): 石井雄道、勝野亮、村井保夫、田原重志、山田昌興、保谷克巳、森田明夫、寺本明、松野彰
  • Journal Title: 日本内分泌学会雑誌 Volume: 91[Suppl, Feb] Pages: 26-28
  • Peer Reviewed
• [Journal Article] 開頭クリッピング術を第一選択とした超高齢者のくも膜下出血の治療成績 (2016)
  • Author(s): 勝野亮、谷川緑野、橋本政明、松野彰
  • Journal Title: Geriatric Neurosurgery Volume: 28 Pages: 9-13
  • Peer Reviewed
• [Journal Article] 脳腫瘍Update （10）Pituitary adenoma（下垂体腺腫） (2016)
  • Author(s): 廣畑倫生、石井雄道、大山健一、松野彰
  • Journal Title: 脳神経外科 Volume: 44 Pages: 793-802
  • Peer Reviewed
• [Journal Article] 脳神経外科領域における内視鏡手術の実際 (2016)
  • Author(s): 大山健一、石井雄道、廣畑倫生、渡邉丈博、松野彰
  • Journal Title: 板橋区医師会医学会誌 Volume: 21 Pages: 202-203
• [Journal Article] Primary diffuse large B-cell lymphomas of central nervous system exhibit remarkably high prevalence of oncogenic MYD88 and CD79B mutations (2015)
  • Author(s): Yamada S, Ishida Y, Matsuno A, Yamazaki K
  • Journal Title: Leukemia and Lymphoma Volume: 56 Issue: 7 Pages: 2141
  • DOI: 10.3109/10428194.2014.979413
  • Peer Reviewed
• [Journal Article] Fascia patchwork closure for endoscopic endonasal skull base surgery (2015)
  • Author(s): Ishii Y, Tahara S, Hattori Y, Teramoto A, Morita A, Matsuno A
  • Journal Title: Neurosurg Rev Volume: 38 Issue: 3 Pages: 551-557
  • DOI: 10.1007/s10143-015-0614-6
  • Peer Reviewed
• [Journal Article] Distal internal carotid artery dissection due to the carotid shunt during carotid endarterectomy (2015)
  • Author(s): Katsuno M, Tanikawa R, Hashimoto M, Matsuno A
  • Journal Title: Brit J Neurosurg Volume: 29 Issue: 6 Pages: 862-864
  • DOI: 10.3109/02688697.2015.1054357
  • Peer Reviewed
• [Journal Article] Landscape of familial isolated and young-onset pituitary adenomas: prospective diagnosis in AIP mutation carriers (2015)
  • Author(s): Hernandez-Ramirez LC, Gabrovska P, Denes J, Stals K,Trivellin G,Tilley D, Ferrau F, Evanson J, Ellard S, Grossman AB, Roncaroli F, Gadelha MR, Korbonits M, and (on behalf of The International FIPA Consortium)
  • Journal Title: J Clin Endocrinol Metab Volume: 100
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Vertebral artery dissection caused by swinging a golf club: case report and literature review (2014)
  • Author(s): Yamada SM, Goto Y, Murakami M, Hoya K, Matsuno A
  • Journal Title: Clin J Sport Med Volume: 24 Pages: 155-157
  • Peer Reviewed
• [Journal Article] Radiation-induced meningiomas in multiple regions, showing rapid recurrence and a high MIB 1 labeling index: a case report and review of the literature. (2014)
  • Author(s): Goto Y, Yamada S, Yamada SM, Nakaguchi H, Hoya K, Murakami M, Yamazaki K, Ishida Y, Matsuno A
  • Journal Title: World J Surg Oncol Volume: 12 Pages: 123-123
  • Peer Reviewed
• [Journal Article] 3,4-dihydroxybenzaldehyde derived from prunus mume seed inhibits oxidative stress and enhances estradiol secretion in human ovarian granulosa tumor cells (2014)
  • Author(s): Kono R, Nomura S, Okuno Y, Nakamura M, Maeno A, Kagiya T, Tokuda A, Inada K, Matsuno A, Utsunomiya T, Utsunomiya H
  • Journal Title: Acta Histochem Cytochem Volume: 47
  • NAID: 130004137833
  • Peer Reviewed
• [Journal Article] A simple, safe, and effective method of cyst wall removal for Rathke's cleft cyst (2014)
  • Author(s): Yamada SM, Ishi Y, Hoya K, Matsuno A
  • Journal Title: Acta Neurochir Volume: 156 Pages: 1923-1924
  • Peer Reviewed
• [Journal Article] Subarachnoid hemorrhage secondary to a ruptured middle cerebral aneurysm in a patient with osteogenesis imperfecta: A case report (2014)
  • Author(s): Hirohata T, Miyawaki S, Mizutani A, Iwakami T, Yamada S, Nishido H, Suzuki Y, Miyamoto S, Hoya K, Murakami M, Matsuno A
  • Journal Title: BMC Neurology Volume: 14 Pages: 150-150
  • Peer Reviewed
• [Journal Article] Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide (2014)
  • Author(s): Matsuno A, Murakami M, Hoya K, Yamada SM, Miyamoto S, Yamada S, Son JH, Nishido H, Ide F, Nagashima H, Sugaya M, Hirohata T, Mizutani A, Okinaga H, Ishii Y, Tahara S, Teramoto A, Osamura RY
  • Journal Title: Med Mol Morphol Volume: 47 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Treatment of pituitary carcinomas and atypical pituitary adenomas: a review (2014)
  • Author(s): Hirohata T, Ishii Y, Matsuno A
  • Journal Title: Neurol Med-Chir (Tokyo) Volume: 54 Pages: 966-973
  • NAID: 130004704538
  • Peer Reviewed
• [Presentation] Neuroendoscopic surgery for pituitary adenomas and parasellar tumor and consideration for difficult cases (2016)
  • Author(s): Matsuno A
  • Organizer: The 7th Academic Congress of International Chinese Neurosurgical Sciences
  • Place of Presentation: Tianjin, China
  • Int'l Joint Research / Invited
• [Presentation] Therapeutic biomarkers in pituitary atypical adenomas and carcinomas (2016)
  • Author(s): Matsuno A
  • Organizer: International Symposium “Endocrine Pathology of Pituitary adenomas Update: in International Symposium on Pituitary Gland and Its Related System
  • Place of Presentation: Hawaii, USA
  • Int'l Joint Research / Invited
• [Presentation] 嚢胞性下垂体及び近傍部病変 (2016)
  • Author(s): 松野彰、石井雄道、大山健一、廣畑倫生
  • Organizer: 第89回日本内分泌学会学術総会
  • Place of Presentation: 京都
  • Invited
• [Presentation] 下垂体腫瘍の病態生理と治療-----生活習慣病治療をふまえて (2016)
  • Author(s): 松野彰
  • Organizer: 第31回奈良脳神経ネットワーク研究会
  • Place of Presentation: 奈良
  • Invited
• [Presentation] Diagnosis and treatment of severe growth hormone deficiency in patients with pituitary and hypothalamic lesions (2015)
  • Author(s): Matsuno A, Ishii Y, Oyama K, Hirohata T
  • Organizer: The 12th annual meeting of Taiwan Neurosurgeons Congress
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-12-05
  • Int'l Joint Research / Invited
• [Presentation] Diagnosis and treatment of severe growth hormone deficiency in patients with pituitary and hypothalamic lesions (2015)
  • Author(s): Matsuno A, Ishii Y, Hirohata T
  • Organizer: WFNS neuroendocrine seminar in the 15th Interim Meeting of WFNS at Rome
  • Place of Presentation: Rome, Italy
  • Year and Date: 2015-09-08
  • Int'l Joint Research / Invited
• [Book] EBMに基づく脳神経疾患の基本治療指針 (2016)
  • Author(s): 石井雄道、廣畑倫生、松野彰
  • Publisher: メジカルビュー社
• [Book] 頭蓋咽頭腫パーフェクトガイド (2016)
  • Author(s): 廣畑倫生、松野彰
  • Publisher: 中外医学社
• [Book] 下垂体疾患診療マニュアル 改訂第2版 (2016)
  • Author(s): 松野彰、廣畑倫生
  • Publisher: 診断と治療社
• [Book] In IN SITU HYBRIDIZATION METHODS in the NEUROMETHODS series 99 (2015)
  • Author(s): Matsuno A, Ishii Y, Murakami M, Hoya K, YamadaSM, Miyamoto S, Son JH, Nishido H, Yamada S, Suzuki Y, Teramoto A, Utsunomiya H, Itoh J, Takekoshi S, Osamura RY, Mizutani A, Okinaga H
  • Publisher: Springer Science + Business Media