Regulation mechanism of intracellular trafficking of somatostatin receptor
| Project/Area Number |
26462190
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | Teikyo University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MIZUTANI AKIKO 帝京平成大学, 健康メディカル学部, 講師 (80465252)
OSAMURA YOSHIYUKI 国際医療福祉大学, 大学院, 教授 (10100992)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 下垂体腺腫 / ソマトスタチン / 受容体 / GH |
|---|
| Outline of Final Research Achievements |
Somatostatin receptor and gsp mutation were analyzed in 56 examples of GH production pituitary adenoma. The adenoma that has plasma membrane expression of somatostatin receptor has significantly more responsive to somatostatin analogues. In 45 examples of pituitary adenomas, expression of somatostatin receptor 2A and 5 was analyzed. GH producing adenomas have expression of both receptors in all samples, and 2 ACTH producing adenomas have expression of somatostatin receptor 5.
|
Report
(4 results)
Research Products
(28 results)
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Landscape of familial isolated and young-onset pituitary adenomas: prospective diagnosis in AIP mutation carriers2015
Author(s)
Hernandez-Ramirez LC, Gabrovska P, Denes J, Stals K,Trivellin G,Tilley D, Ferrau F, Evanson J, Ellard S, Grossman AB, Roncaroli F, Gadelha MR, Korbonits M, and (on behalf of The International FIPA Consortium)
-
Journal Title
J Clin Endocrinol Metab
Volume: 100
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
[Journal Article] 3,4-dihydroxybenzaldehyde derived from prunus mume seed inhibits oxidative stress and enhances estradiol secretion in human ovarian granulosa tumor cells2014
Author(s)
Kono R, Nomura S, Okuno Y, Nakamura M, Maeno A, Kagiya T, Tokuda A, Inada K, Matsuno A, Utsunomiya T, Utsunomiya H
-
Journal Title
Acta Histochem Cytochem
Volume: 47
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] Subarachnoid hemorrhage secondary to a ruptured middle cerebral aneurysm in a patient with osteogenesis imperfecta: A case report2014
Author(s)
Hirohata T, Miyawaki S, Mizutani A, Iwakami T, Yamada S, Nishido H, Suzuki Y, Miyamoto S, Hoya K, Murakami M, Matsuno A
-
Journal Title
BMC Neurology
Volume: 14
Pages: 150-150
Related Report
Peer Reviewed
-
[Journal Article] Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide2014
Author(s)
Matsuno A, Murakami M, Hoya K, Yamada SM, Miyamoto S, Yamada S, Son JH, Nishido H, Ide F, Nagashima H, Sugaya M, Hirohata T, Mizutani A, Okinaga H, Ishii Y, Tahara S, Teramoto A, Osamura RY
-
Journal Title
Med Mol Morphol
Volume: 47
Pages: 1-7
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Book] In IN SITU HYBRIDIZATION METHODS in the NEUROMETHODS series 992015
Author(s)
Matsuno A, Ishii Y, Murakami M, Hoya K, YamadaSM, Miyamoto S, Son JH, Nishido H, Yamada S, Suzuki Y, Teramoto A, Utsunomiya H, Itoh J, Takekoshi S, Osamura RY, Mizutani A, Okinaga H
Publisher
Springer Science + Business Media
Related Report
