| Project/Area Number |
26462194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
黒岩 敏彦 大阪医科大学, 医学部, 教授 (30178115)
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| Research Collaborator |
ISHIKAWA Toshihisa (60193281)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 光線力学診断 / 光線力学療法 / ５－アミノレブリン酸 / ポルフィリン / 手術ロボット / 悪性神経膠腫 / 脳腫瘍 / ５アミノレブリン酸 / 腫瘍可視化 / 5アミノレブリン酸 / 悪性リンパ腫 |
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| Outline of Final Research Achievements |
The 5-ALA fluorescence guided excision method improves the resection rate of malignant glioma and improves the patient's prognosis. However, there are unresolved problems as a diagnostic method. For example, there are problems of false negatives due to lack of excitation light intensity, and ambiguity of diagnosis due to macroscopic subjective judgment. In order to overcome these drawbacks, development of a safe auxiliary light source and development of quantitative fluorescence diagnostic apparatus are desired.
In this study, we developed devices (ultrasound scalpel driven by fluorescence sensor, fluorescence sensor driven LED light source device for diagnosis, LED light source device for diagnosis) that overcome these drawbacks, and applied it clinically and verified its usefulness.
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