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Combined WT1 vaccine immunotherapy and targeted chemotherapy against metastatic brain tumor

Research Project

Project/Area Number 26462195
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionKindai University

Principal Investigator

IZUMOTO Shuichi  近畿大学, 医学部, 准教授 (40324769)

Co-Investigator(Kenkyū-buntansha) 友金 祐介  兵庫医科大学, 医学部, 講師 (10412008)
奥田 武司  近畿大学, 医学部, 講師 (10340796)
藤田 貢  近畿大学, 医学部, 准教授 (40609997)
加藤 天美  近畿大学, 医学部, 教授 (00233776)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords免疫療法 / WT1 / 転移性脳腫瘍 / 悪性脳腫瘍 / 免疫治療 / WT1
Outline of Final Research Achievements

WT1 based cancer immunotherapy is a therapy, in which HLA class I-binding 9-mer WT1 peptide is administered intradermally, to induce WT1-specific cellular immune responses. We investigated the safety and immune-response of vaccine therapy of WT1 against metastatic brain tumors. Metastatic brain tumor cells in the animal model showed expression of WT1, and immune cells during vaccination were accumulated focally, but the response of WT1 vaccination was poor. In patients of metastatic brain tumors-breast cancer, accumulation of WT1-specific immune response and WT1-specific killer T cells were poor on the surface of tumor cells. Immunohistochemical analysis on skin specimens, where WT1 peptide was administered intradermally, revealed reactive proliferation of macrophages with giant cell formation and infiltration of CD4+ and CD8+ T, and CD20+ B lymphocytes in the lower dermis. These findings provide basic information about local immune responses elicited in the vaccination site.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) Book (2 results)

  • [Journal Article] Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide.2016

    • Author(s)
      Oji Y, Hashimoto N, Tsuboi A, Murakami Y, Iwai M, Kagawa N, Chiba Y, Izumoto S, Elisseeva O, Ichinohasama R, Sakamoto J, Morita S, Nakajima H, Takashima S, Nakae Y, Nakata J, Kawakami M, Nishida S, Hosen N, Fujiki F, Morimoto S, Adachi M, Iwamoto M, Oka Y, Yoshimine T, Sugiyama H.
    • Journal Title

      Int J Cancer.

      Volume: 139 Issue: 6 Pages: 1391-401

    • DOI

      10.1002/ijc.30182

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical outcome of node-negative oligometastatic non-small cell lung cancer.2016

    • Author(s)
      Sakai K, Takeda M, Hayashi H, Tanaka K, Okuda T, Kato A, Nishimura Y, Mitsudomi T, Koyama A, Nakagawa K.
    • Journal Title

      Thrac Cancer

      Volume: 7 Issue: 6 Pages: 670-675

    • DOI

      10.1111/1759-7714.12386

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 頭蓋内血管腫(SFTの亜型として)の診断、治療と長期予後レビュー2016

    • Author(s)
      泉本修一(4名省略)
    • Journal Title

      Neuro-Oncologyの進歩

      Volume: 23 Pages: 1-1

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of ABCG2 enhances chemo-sensitivity of murine glioma stem cell-like cells to temozolomide and reduces shoroid-forming capability.2015

    • Author(s)
      Yoshioka H, Izumoto S(5名省略)
    • Journal Title

      Acta Med Kindai Univ

      Volume: 39 Pages: 105-113

    • Related Report
      2015 Research-status Report
    • Open Access
  • [Journal Article] Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response2015

    • Author(s)
      Naoya Hashimoto, Akihiro Tsuboi, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Manabu Kinoshita, Noriyuki Kijima, Yoshihiro Oka, Soyoko Morimoto, Hiroko Nakajima, Satoshi Morita, Junichi Sakamoto, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Norio Arita, Toshiki Yoshimine, Haruo Sugiyama
    • Journal Title

      Cancer Immunology Immunotherapy

      Volume: - Issue: 6 Pages: 707-16

    • DOI

      10.1007/s00262-015-1674-8

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Successful Combination of Pallidal and Thalamic Stimulation for Intractable Involuntary Movements in Patients with Neuroacanthocytosis2015

    • Author(s)
      Nakano N, kato A(4名省略)
    • Journal Title

      World Neurosurg

      Volume: 84 Issue: 4 Pages: 1177-1184

    • DOI

      10.1016/j.wneu.2015.06.052

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The translation elongation factor eEF2 is a novel tumor-associated antigen overexpressed in various types of cancers.2014

    • Author(s)
      Oji Y, Tatsumni N, Izumoto S (34 名省略)
    • Journal Title

      Int J Oncol

      Volume: 44 Issue: 5 Pages: 1461-1469

    • DOI

      10.3892/ijo.2014.2318

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 後頭蓋窩上衣腫の治療、とくに側方進展例に対する手術摘出と後頭蓋窩IMRTについて2016

    • Author(s)
      泉本修一、奥田武司、田崎貴之、友金祐介、加藤天美
    • Organizer
      第34回日本脳腫瘍学会学術集会
    • Place of Presentation
      甲府富士屋ホテル、甲府
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] 膠芽腫におけるWT1ワクチン治療の長期免疫維持と注射局所および血中の免疫反応2015

    • Author(s)
      泉本修一(6名省略)
    • Organizer
      第32回日本脳腫瘍学会学術集会
    • Place of Presentation
      グランドプリンスホテル京都(京都)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Harmonization of imunohistochemical evaluation of WT1 expression and monitoring of WT1-specific humoral immune resonse2014

    • Author(s)
      Oji y, Anguille S, Izumoto S (28名省略)
    • Organizer
      The 7th International Conference on WT1 in human neoplasia
    • Place of Presentation
      Barcelona
    • Year and Date
      2014-04-22 – 2014-04-23
    • Related Report
      2014 Research-status Report
  • [Book] 脳腫瘍学-基礎研究と臨床研究の進歩2016

    • Author(s)
      泉本修一2名省略)
    • Total Pages
      700
    • Publisher
      日本臨床社
    • Related Report
      2015 Research-status Report
  • [Book] 転移性脳腫瘍 診断/治療/管理2014

    • Author(s)
      奥田武司、中洲庸子
    • Total Pages
      158
    • Publisher
      メディカ出版
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2020-01-20  

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