Analysis of the mechanism of repetitive transcranial magnetic stimulation for chronic pain: fMRI analysis of rat model
| Project/Area Number |
26462203
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
Saitoh Youichi 大阪大学, 医学系研究科, 特任教授(常勤) (20252661)
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| Co-Investigator(Kenkyū-buntansha) |
吉岡 芳親 大阪大学, 免疫学フロンティア研究センター, 特任教授(常勤) (00174897)
清水 豪士 大阪大学, 医学部附属病院, 医員 (10721102)
関野 正樹 東京大学, 大学院工学系研究科(工学部), 准教授 (20401036)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | rTMS / 神経障害性疼痛 / 11.7T / 機能的結合 / 11.7Ｔ |
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| Outline of Final Research Achievements |
Repetitive transcranial magnetic stimulation (rTMS) is expected to relieve intractable neuropathic pain. In this research, we made chronic pain model in rats with ligated sciatic nerve, and tried to analyze detailed image to investigate the pathophysiology of chronic pain and best stimulation parameter of rTMS. We prepared anesthesia equipment, rTMS machine and electromyogram. We successfully obtained anatomical image of rat brain in 11.7T MRI according to preceded anesthesia method and MRI parameters in 7T MRI. However, our 11.7T MRI needed placement of the animal in vertical position. We cannot obtain resting-state functional MRI of rat in stable anesthesia.
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Report
(4 results)
Research Products
(104 results)
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[Journal Article] Efficacy of deep rTMS for neuropathic pain in the lower limb; a randomized, double-blinded, crossover trial of an H-coil and figure-8 coil.2017
Author(s)
Shimizu T, Hosomi K, Maruo T, Goto Y, Yokoe M, Kageyama Y, Shimokawa T, Yoshimine T, Saitoh Y
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Journal Title
J Neurosurg.
Volume: 3
Issue: 5
Pages: 1-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Daily repetitive transcranial magnetic stimulation for post-stroke upper limb paresis in the subacute period2016
Author(s)
Hosomi K, Morris S, Sakamoto T, Taguchi J, Maruo T, Kageyama Y, Kinoshita Y, Goto Y, Shimokawa T, Koyama T, Saitoh Y
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Journal Title
J Stroke Cerebrovasc Dis.
Volume: 25(7)
Issue: 7
Pages: 1655-64
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Induced sensorimotor brain plasticity controls pain in phantom limb patients2016
Author(s)
Yanagisawa T, Fukuma R, Seymour B, Hosomi K, Kishima H, Shimizu T, Yokoi H, Hirata M, Yoshimine T, Kamintani Y, Saitoh Y
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Journal Title
Nature Communications
Volume: 7
Issue: 1
Pages: 13209-13209
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus2016
Author(s)
Khoo HM, Kishima H, Tani N, Oshino S, Maruo T, Hosomi K, Yanagisawa T, Kazui H, Watanabe Y, Shimokawa T, Aso T, Kawaguchi A, Yamashita F, Saitoh Y, Yoshimine T
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Journal Title
J Neurosurg.
Volume: 124
Issue: 2
Pages: 350-358
DOI
Related Report
Peer Reviewed
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[Presentation] Neuromodulation of Phantom Limb Pain Using MEG-BMI2016
Author(s)
T. Yanagisawa, R. Fukuma, B. Seymour, K. Hosomi, H. Kishima, T. Shimizu, H. Yokoi, M. Hirata, T. Yoshimine, Y. Kamitani, Y. Saitoh
Organizer
IASP 16th World Congress on Pain
Place of Presentation
Yokohama,japan
Year and Date
2016-09-27
Related Report
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[Presentation] rTMS experiences - present and future2015
Author(s)
Hosomi K, Goto Y, Shimizu T, Nakamura H, Saitoh Y
Organizer
15th European Congress on Clinical Neurophysiology
Place of Presentation
Bruno, Czech Republic
Year and Date
2015-10-01
Related Report
Int'l Joint Research / Invited
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[Presentation] Functional connectivity study on repetitive transcranial magnetic stimulation for central post-stroke pain2015
Author(s)
Hosomi K, Shimizu T, Maruo T, Watanabe Y, Khoo HM, Tani N, Goto Y, Kishima H, Yoshimine Y, Saitoh Y
Organizer
15th European Congress on Clinical Neurophysiology
Place of Presentation
Bruno, Czech Republic
Year and Date
2015-10-01
Related Report
Int'l Joint Research
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