Functional connectivy after operation for spinal cord injury
Project/Area Number |
26462205
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | Osaka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
岩月 幸一 大阪大学, 医学系研究科, 准教授 (80346204)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 神経再生 / 脊髄損傷 / 嗅粘膜 / fMRI / 神経因性疼痛 / 機能的結合 |
Outline of Final Research Achievements |
We performed olfactory mucosa transplantation to 5 patients of complete spinal cord injury. 4 patients showed lower extremity functional recovery. Functional MRI was performed before and after operation. Functional MRI showed activation of left precentral gyrus and right cerebellum. In contrast, activation at left postcentral gyrus, left parahippocampal gyrus and left globus pallidus was decreased. We detected alteration of brain activity by lower extremity recovery after olfactory mucosa transplantation.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Motor evoked potential and voluntary EMG activity after olfactory mucosal autograft transplantation in a case of chronic, complete spinal cord injury: case report2016
Author(s)
Iwatsuki K, Tajima F, Sankai Y, Ohnishi YI, Nakamura T, Ishihara M, Hosomi K, Ninomiya K, Moriwaki T, Yoshimine T.
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Journal Title
Spinal cord series and cases
Volume: Jan 7;2
Issue: 1
Pages: 15018-15018
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Isolation of human adult olfactory sphere cells as a cell source of neural progenitors.2015
Author(s)
Ohnishi Y1, Iwatsuki K2, Ishihara M2, Shikina T3, Shinzawa K4, Moriwaki T2, Ninomiya K2, Ohkawa T2, Umegaki M2, Kishima H2, Yoshimine T2.
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Journal Title
Stem Cell Research
Volume: 15(1)
Issue: 1
Pages: 23-29
DOI
Related Report
Peer Reviewed / Open Access
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