Functional connectivy after operation for spinal cord injury

• Project/Area Number: 26462205
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Osaka University
• Principal Investigator: Ishihara Masahiro 大阪大学, 医学系研究科, 特任研究員 (00533803)
• Co-Investigator(Kenkyū-buntansha): 岩月 幸一 大阪大学, 医学系研究科, 准教授 (80346204)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経再生 / 脊髄損傷 / 嗅粘膜 / ｆMRI / 神経因性疼痛 / 機能的結合

Outline of Final Research Achievements

We performed olfactory mucosa transplantation to 5 patients of complete spinal cord injury. 4 patients showed lower extremity functional recovery. Functional MRI was performed before and after operation. Functional MRI showed activation of left precentral gyrus and right cerebellum. In contrast, activation at left postcentral gyrus, left parahippocampal gyrus and left globus pallidus was decreased. We detected alteration of brain activity by lower extremity recovery after olfactory mucosa transplantation.

Research Products

• [Journal Article] A Pilot Clinical Study of Olfactory Mucosa Autograft for Chronic Complete Spinal Cord Injury (2016)
  • Author(s): Iwatsuki K1, Tajima F, Ohnishi Y, Nakamura T, Ishihara M, Hosomi K, Ninomiya K, Moriwaki T, Yoshimine T.
  • Journal Title: Neurologia medico-chirurgica Volume: 56 Issue: 6 Pages: 285-292
  • DOI: 10.2176/nmc.oa.2015-0320
  • NAID: 130005157732
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access
• [Journal Article] Motor evoked potential and voluntary EMG activity after olfactory mucosal autograft transplantation in a case of chronic, complete spinal cord injury: case report (2016)
  • Author(s): Iwatsuki K, Tajima F, Sankai Y, Ohnishi YI, Nakamura T, Ishihara M, Hosomi K, Ninomiya K, Moriwaki T, Yoshimine T.
  • Journal Title: Spinal cord series and cases Volume: Jan 7;2 Issue: 1 Pages: 15018-15018
  • DOI: 10.1038/scsandc.2015.18
  • Peer Reviewed / Open Access
• [Journal Article] A case of long-term survival after multimodal local treatments of intramedullary spinal cord metastasis of squamous cell lung cancer (2016)
  • Author(s): Minomo S, Tokoro A, Utsumi T, Ishihara M, Akira M, Atagi S.
  • Journal Title: Journal of thoracic disease Volume: Aug;8(8) Issue: 8 Pages: 681-3
  • DOI: 10.21037/jtd.2016.06.58
  • Peer Reviewed
• [Journal Article] A Pilot Clinical Study of Olfactory Mucosa Autograft for Chronic Complete Spinal Cord Injury. (2016)
  • Author(s): Iwatsuki K, Tajima F, Ohnishi YI, Nakamura T, Ishihara M, Hosomi K, Ninomiya K, Moriwaki T, Yoshimine T.
  • Journal Title: Neuroligia medico-chirurgica Volume: in press
  • NAID: 130005157732
  • Peer Reviewed / Open Access
• [Journal Article] Isolation of human adult olfactory sphere cells as a cell source of neural progenitors. (2015)
  • Author(s): Ohnishi Y1, Iwatsuki K2, Ishihara M2, Shikina T3, Shinzawa K4, Moriwaki T2, Ninomiya K2, Ohkawa T2, Umegaki M2, Kishima H2, Yoshimine T2.
  • Journal Title: Stem Cell Research Volume: 15(1) Issue: 1 Pages: 23-29
  • DOI: 10.1016/j.scr.2015.04.006
  • Peer Reviewed / Open Access
• [Journal Article] Presence of trans-synaptic neurons derived from olfactory mucosa transplanted after spinal cord injury. (2014)
  • Author(s): Moriwaki T, Iwatsuki K, Mochizuki-Oda N, Ohnishi Y, Ishihara M, Umegaki M, Ninomiya K, Yoshimine T.
  • Journal Title: Spine Volume: 15;39(16) Issue: 16 Pages: 1267-73
  • DOI: 10.1097/brs.0000000000000386
  • Peer Reviewed / Open Access
• [Journal Article] Primary olfactory mucosal cells promote axonal outgrowth in a three-dimensional assay (2014)
  • Author(s): Ishihara, Masahiro; Mochizuki-Oda, Noriko; Iwatsuki, Koichi et al.
  • Journal Title: Journal of Neuroscience Research Volume: ahead of print Issue: 7 Pages: 270-4
  • DOI: 10.1002/jnr.23367
  • Peer Reviewed
• [Presentation] 嗅粘膜組織による神経軸索誘引効果の検討 (2015)
  • Author(s): 石原正浩、小田紀子、岩月幸一、二宮貢士、森脇祟、吉峰俊樹
  • Organizer: 第30日本脊髄外科学会
  • Place of Presentation: 北海道立道民活動センターかでる2.7
  • Year and Date: 2015-06-25