The effect of corpus callosal stimulation on epileptic cortical hyperexcitability
Project/Area Number |
26462208
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | Osaka University |
Principal Investigator |
Satoru Oshino 大阪大学, 医学系研究科, 助教 (40403050)
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Co-Investigator(Kenkyū-buntansha) |
貴島 晴彦 大阪大学, 医学系研究科, 教授 (10332743)
三好 智満 大阪大学, 医学系研究科, 助教 (70314309)
中村 元 大阪大学, 医学系研究科, 助教 (80533794)
枝川 光太朗 大阪大学, 医学部附属病院, 医員 (40722806)
小林 真紀 大阪大学, 医学部附属病院, 医員 (10570575)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 機能脳神経外科 / てんかん / 白質 / 電気刺激 / 動物実験 / ペニシリン / 興奮性 |
Outline of Final Research Achievements |
Corpus callosum is the largest bundle of white matter and which consists of mainly inhibitory fiber. We studied whether there were some inhibitory effects of corpus callosum stimulation on epileptic cortical hyper-excitability. Using cat model under general anesthesia, we recorded "Penicillin induced epileptic discharge" and its change under the stimulation of corpus callosum. As a result, we could not find certain inhibitory change on the epileptic discharge. Conversely, the epileptic discharge was increased by stimulation in some of the cases, although the parameters of stimulation were varied. These results indicates that corpus callosum stimulation has certain impact on cortical excitability, but electrical stimulation with the parameters we have attempted does not induced its physiological inhibitory effect. This interesting findings lead us to apply this model to new research, which investigates epileptic propagation through white matter.
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Report
(4 results)
Research Products
(88 results)
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[Journal Article] Navigation-assisted trans-inferotemporal cortex selective amygdalohippocampectomy for mesial temporal lobe epilepsy; preserving the temporal stem2017
Author(s)
Kishima H, Kato A, Oshino S, Tani N, Maruo T, Khoo HM, Yanagisawa T, Edakawa K, Kobayashi M, Tanaka M, Hosomi K, Hirata M, Yoshimine T
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Journal Title
Neurol Res
Volume: 39(3)
Pages: 223-230
Related Report
Peer Reviewed
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[Journal Article] Electrical stimulation of the parahippocampal gyrus for prediction of posthippocampectomy verbal memory decline2016
Author(s)
Tani N, Kishima H, Khoo HM, Yanagisawa T, Oshino S, Maruo T, Hosomi K, Hirata M, Kazui H, Nomura KT, Aly MM, Kato A, Yoshimine T
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Journal Title
J Neurosurg.
Volume: 15
Issue: 5
Pages: 1-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus.2015
Author(s)
Khoo HM, Kishima H, Tani N, Oshino S, Maruo T, Hosomi K, Yanagisawa T, Kazui H, Watanabe Y, Shimokawa T, Aso T, Kawaguchi A, Yamashita F, Saitoh S, Yoshimine T.
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Journal Title
J Neurosurgery.
Volume: 未定
Related Report
Peer Reviewed
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[Journal Article] Low-frequency subthalamic nucleus stimulation in Parkinson's disease: a randomized clinical trial.2014
Author(s)
Khoo HM, Kishima H, Hosomi K, Maruo T, Tani N, Oshino S, Shimokawa T, Yokoe M, Mochizuki H, Saitoh Y, Yoshimine T.
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Journal Title
Mov Disord.
Volume: 29(2)
Issue: 2
Pages: 2270-4
DOI
Related Report
Peer Reviewed
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[Journal Article] Rapid decline in bone turnover markers but not bone mineral density in acromegalic patients after transsphenoidal surgery2014
Author(s)
Tamada D, Kitamura T, Onodera T, Tabuchi Y, Fukuhara A, Oshino S, Saitoh Y, Hamasaki T, Otsuki M, Shimomura I.
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Journal Title
Endocrine Journal
Volume: 61
Issue: 3
Pages: 231-237
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed
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[Presentation] 神経変性疾患に対するバクロフェン髄腔内持続投与治療2016
Author(s)
押野悟,貴島晴彦,細見晃一,枝川光太朗,クーウィミン,柳澤琢史,後藤雄子,小林真紀,田中將貴,清水豪士,谷直樹,尾知之,田雅之,吉峰俊樹
Organizer
第55回日本定位機能神経外科学会
Place of Presentation
仙台
Year and Date
2016-01-23
Related Report
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[Presentation] 頭蓋内電極留置のpitfallと工夫2016
Author(s)
押野悟, 貴島晴彦, 柳澤琢文, 枝川光太朗, 小林真紀, 田中將貴, 平田雅之, クーウィミン, 吉峰俊樹
Organizer
第39回日本てんかん外科学会
Place of Presentation
仙台
Year and Date
2016-01-21
Related Report
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[Presentation] 特発性正常圧水頭症患者での脳内機能的結合の変化2015
Author(s)
Khoo Hui Ming, 貴島晴彦, 谷直樹, 押野 悟, 圓尾知之, 細見晃一, 柳澤琢史, 數井裕光, 渡邊嘉之, 吉峰俊樹
Organizer
東西合同脳神経外科認知症研究会(第 5 回関西脳神経外科認知症研究会・第 4 回関東脳神経外科認知症研究会 合同開催)
Place of Presentation
大阪
Year and Date
2015-04-11
Related Report
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[Presentation] Alternation of cross frequency coupling in the pre-ictal iEEG of epileptic patients2014
Author(s)
Edagawa K, Kishima H, Yanagisawa T, Oshino S, Inoue Y, Kobayashi M, Hosomi K, Khoo HM, Hirata M, Yoshimine T
Organizer
2014 Annual Meeting of the American Epilepsy Society
Place of Presentation
Seattle, USA
Year and Date
2014-12-06 – 2014-12-07
Related Report
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[Presentation] Frameless image-guided stereotactic implantation of depth electrodes via craniotomy for pharmacoresistant epilepsy2014
Author(s)
Khoo HM, Kishima H, Oshino S, Tani N, Maruo T, Yanagisawa T, Edagawa K, Inoue Y, Hirata M, Yoshimine T
Organizer
2014 Annual Meeting of the American Epilepsy Society
Place of Presentation
Seattle, USA
Year and Date
2014-12-06 – 2014-12-07
Related Report
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[Presentation] Surgery for refractory epilepsy with MRI positive lesions in childhood2014
Author(s)
Kishima H, Oshino S, Khoo HM, Kobayashi M, Yanagisawa T, Edagawa K, Hosomi K, Inoue Y, Shimizu T, Hirata M, Yoshimine T
Organizer
The 8th Asian Epilepsy Surgery Congress
Place of Presentation
Tokyo,Japan
Year and Date
2014-10-05 – 2014-10-06
Related Report
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[Presentation] Frameless image-guided stereotactic implantation of depth electrodes via craniotomy for pharmacoresistant epilepsy2014
Author(s)
Khoo HM, Kishima H, Oshino S, Tani N, Maruo T, Yanagisawa T, Edagawa K, Inoue Y, Hirata M, Yoshimine T
Organizer
The 8th Asian Epilepsy Surgery Congress
Place of Presentation
Tokyo,Japan
Year and Date
2014-10-05 – 2014-10-06
Related Report
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[Presentation] Alternation of cross frequency coupling in the pre-ictal iEEG of epileptic patients2014
Author(s)
Edagawa K, Kishima H, Yanagisawa T, Oshino S, Inoue Y, Kobayashi M, Hosomi K, Khoo HM, Hirata M, Yoshimine T
Organizer
The 8th Asian Epilepsy Surgery Congress
Place of Presentation
Tokyo,Japan
Year and Date
2014-10-05 – 2014-10-06
Related Report
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[Presentation] The efficacy of the study with intracranial electroencephalography in relation to epileptic pathology2014
Author(s)
Oshino S, Kishima H, Hirata M, Yanagisawa T, Edagawa K, Khoo HM, Inoue Y, Tani N, Kobayashi M, Yoshimine T
Organizer
The 8th Asian Epilepsy Surgery Congress
Place of Presentation
Tokyo,Japan
Year and Date
2014-10-05 – 2014-10-06
Related Report
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