The anti-epileptic effect of spinal cord stimulation in kainic acid induced epilepsy rat model
| Project/Area Number |
26462209
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders |
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Principal Investigator |
KONDO AKIHIKO 独立行政法人国立病院機構(静岡・てんかん神経医療センター臨床研究部), その他部局等, その他 (20721137)
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| Co-Investigator(Kenkyū-buntansha) |
安原 隆雄 岡山大学, 医歯薬学総合研究科, 講師 (50457214)
亀田 雅博 岡山大学, 医歯薬学総合研究科, 助教 (50586427)
上利 崇 岡山大学, 大学病院, 助教 (60423290)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | てんかん / 脊髄刺激 / SCS / epilepsy |
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| Outline of Final Research Achievements |
Male Fischer 344 rats received SCS(spinal cord stimulation) with an epidural electrode at C1-2 level for one week. After SCS, the rats were injected with KA (12mg/kg, i.p.).The behavior was monitored for 6 h following KA injection and assigned a score for seizure stage using Racine scale. As a result, SCS with a frequency of 200Hz significantly reduced seizure severity in Kainic acid induced epilepsy rats model. The result suggests that SCS with high frequency exerts anticonvulsant effects.
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Report
(4 results)
Research Products
(3 results)
