| Project/Area Number |
26462210
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
Koji Iida 広島大学, 病院(医), 講師 (20304412)
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| Co-Investigator(Kenkyū-buntansha) |
香川 幸太 広島大学, 病院(医), 医科診療医 (40726981)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIHARA Kumatoshi 広島国際大学, 薬学部, 教授 (20212912)
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| Research Collaborator |
KATAGIRI Masaya 広島大学, 大学病院, 医科診療医 (40793451)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | Vagus nerve stimulation / Epilepsy / Noda Epileptic Rat / 迷走神経刺激術 / Ascending arousal system / Noda epileptic rat / Vagal nerve stimulation / 非定型欠神発作 / 強直間代性けいれん / vagus nerve stimulation / noda epileptic rat / mechanism / c-Fos |
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| Outline of Final Research Achievements |
We performed vagus nerve stimulation to genetic epileptic model rat 'NER'. Acute stimulation of 2 hours showed anti-epileptic effect to generalized tonic-clonic seizure. Chronic stimulation of 4 weeks showed anti-epileptic effect to the absence like seizure and reduced duration of the absence seizures. We also studied neuronal activity changes among the rat brains after acute and chronic stimulation using immunofluorescence staining of c-Fos and delta-FosB. In the VNS group, we observed hyper neuronal activations in the nuclei corresponding with ascending reticular activating system. Furthermore, there were specific hyper neuronal activation in the locus caeruleus after acute stimulation and in the laterodorsal tegmental nucleus after chronic stimulation. Time dependent anti-epileptic effect of VNS may be derived from the difference of these activated cites.
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