Evaluation of physiological and pathological brain activities by simultaneous recording of single unit and intracranial EEG

• Project/Area Number: 26462221
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Jichi Medical University (2015-2016); Tokyo Health Care University (2014)
• Principal Investigator: Kawai Kensuke 自治医科大学, 医学部, 教授 (70260924)
• Co-Investigator(Kenkyū-buntansha): 國井 尚人 東京大学, 医学部附属病院, 助教 (80713940)
• Co-Investigator(Renkei-kenkyūsha): MATSUO Takeshi 東京医療保健大学, 医学保健学部, 講師 (10733941)
• Research Collaborator: IBAYASHI Kenji 東京大学, 医学系研究科, 大学院生
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 単一ニューロン記録 / 頭蓋内脳波 / 頭蓋内電極 / ブレインマシンインターフェース / てんかん / single neuron recording / epilepsy / brain / human / electroencephalography / intracranial electrode / intracranial EEG / epilepsy surgery

Outline of Final Research Achievements

The present study is the first attempt in Japan to analyze physiological and pathological brain activities using custom-made electrodes for simultaneous recording of intracranial EEG and single neuron firing. The study clarified some aspects of thus-far undetected brain activities and suggested possibilities that those recording promote the understanding of physiological and pathological neural processes. Furthermore, it was expected that those recording improve localization of epileptogenic zones and outcome of surgical treatment of epilepsy, improve the quality of functional mapping, and furhter help developing BMI for treatment of brain diseases and support for disabled as implantable neuromodulation therapy in future.

Research Products

• [Journal Article] Long-term outcome and neuroradiologic changes after multiple hippocampal transection combined with multiple subpial transection or lesionectomy for temporal lobe epilepsy (2016)
  • Author(s): Usami K, Kubota M, Kawai K, Kunii N, Matsuo T, Ibayashi K, Takahashi M, Kamada K, Momose T, Aoki S, Saito N
  • Journal Title: Epilepsia Volume: 57(6) Issue: 6 Pages: 931-940
  • DOI: 10.1111/epi.13374
  • Peer Reviewed / Open Access
• [Journal Article] Effect of vagus nerve stimulation on neural adaptation in thalamo-cortical system in rats (2016)
  • Author(s): Shiramatsu, T. I. Hitsuyu, R. Ibayashi, K. Kanzaki, R. Kawai, K. Takahashi, H.
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc Volume: 2016 Pages: 1834-1837
  • DOI: 10.1109/embc.2016.7591076
  • Peer Reviewed
• [Journal Article] Machine Learning of DTI Structural Brain Connectomes for Lateralization of Temporal Lobe Epilepsy (2016)
  • Author(s): Kamiya, K. Amemiya, S. Suzuki, Y. Kunii, N. Kawai, K. Mori, H. Kunimatsu, A. Saito, N. Aoki, S. Ohtomo, K.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 15 Issue: 1 Pages: 121-129
  • DOI: 10.2463/mrms.2015-0027
  • NAID: 130005118987
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Epilepsy Surgery: Current Status and Ongoing Challenges (2015)
  • Author(s): Kawai K
  • Journal Title: Neurologia medico-chirurgica Volume: 55 Issue: 5 Pages: 357-366
  • DOI: 10.2176/nmc.ra.2014-0414
  • NAID: 130005069873
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed
• [Journal Article] Spontaneous Temporal Pole Encephalocele Presenting with Epilepsy: Report of Two Cases (2015)
  • Author(s): Shimada S, Kunii N, Kawai K, Usami K, Matsuo T, Uno T, Koizumi T, Saito N
  • Journal Title: World Neurosurg Volume: 84 Issue: 3 Pages: 867.e1-867.e6
  • DOI: 10.1016/j.wneu.2015.04.028
  • Peer Reviewed
• [Journal Article] Dissociated roles of the inferior frontal gyrus and superior temporal sulcus in audiovisual processing: top-down and bottom-up mismatch detection (2015)
  • Author(s): Uno, T., Kawai, K., Sakai, K., Wakebe, T., Ibaraki, T., Kunii, N., Matsuo, T., & Saito, N.
  • Journal Title: PLoS ONE Volume: 10 Issue: 3 Pages: e0122580-e0122580
  • DOI: 10.1371/journal.pone.0122580
  • Peer Reviewed / Open Access
• [Journal Article] The significance of parahippocampal high gamma activity for memory preservation in surgical treatment of atypical temporal lobe epilepsy (2014)
  • Author(s): Kunii N,Kamada K（3番目）、他3名
  • Journal Title: Epilepsia Volume: 55(10) Issue: 10 Pages: 1594-1601
  • DOI: 10.1111/epi.12764
  • Peer Reviewed / Open Access
• [Journal Article] Decoding visual object categories from temporal correlations of ECoG signals. (2014)
  • Author(s): Majima K, Matsuo T, Kawasaki K, Kawai K, Saito N, Hasegawa I, Kamitani Y.
  • Journal Title: Neuroimage Volume: 90 Pages: 74-83
  • Peer Reviewed
• [Journal Article] Alternating zones selective to faces and written words in the human ventral occipitotemporal cortex (2013)
  • Author(s): Matsuo T, Kawasaki K, Kawai K, Majima K, Masuda H, Murakami H, Kunii N, Kamitani Y, Kameyama S, Saito N, Hasegawa I
  • Journal Title: Cereb Cortex Volume: (in press) Issue: 5 Pages: 1265-77
  • DOI: 10.1093/cercor/bht319
  • Peer Reviewed
• [Presentation] 新型ハイブリッド型電極を用いたヒト顔面運動野の神経活動計測と平仮名調音のデコーディング (2016)
  • Author(s): 井林賢志、國井尚人、松尾健、石下洋平、嶋田勢二郞、川合謙介、斉藤延人
  • Organizer: 第3回 脳神経外科BMI懇話会
  • Place of Presentation: 旭川医科大学研究棟１階小講堂 (北海道、旭川市)
• [Presentation] Decoding articulation by neuronal spike frequency and power spectrum recorded from human face motor cortex (2016)
  • Author(s): Ibayashi K, Matsuo T, Kunii N, Ishishita Y, Shimada S, Kawai K, Saito N
  • Organizer: Human Single Unit Meeting
  • Place of Presentation: Beckman Institute, California Institute of Technology (Pasadena, California, USA)
  • Int'l Joint Research
• [Presentation] Decoding articulation by neuronal spike frequency and power spectrum recorded from human face motor cortex (2016)
  • Author(s): Ibayashi K, Matsuo T, Kunii N, Ishishita Y, Shimada S, Kawai K, Saito N
  • Organizer: 北米神経科学会
  • Place of Presentation: San Diego Convention Center (San Diego, California, USA)
  • Int'l Joint Research
• [Presentation] Decoding articulation of Japanese alphabet by unit firing pattern and power spectrum obtained from the human face motor cortex (2016)
  • Author(s): Ibayashi K, Matsuo T, Kunii N, Ishishita Y, Shimada S, Kawai K, Saito N
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜 (神奈川県、横浜市)
• [Presentation] 単一ニューロン記録を用いた発声の復号化 (2015)
  • Author(s): 井林賢志、松尾健、國井尚人、川合謙介、斉藤延人
  • Organizer: 第２回脳神経BMI懇話会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-14
• [Presentation] 海馬傍回高周波脳律動活動はTLE術後記銘力低下の予測因子となり得るか (2015)
  • Author(s): 國井尚人，川合謙介，鎌田恭輔、太田貴裕、宇野健志、松尾健、斉藤延人
  • Organizer: 第17回日本ヒト脳機能マッピング学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-02
• [Presentation] てんかん外科における次の一手ーsingle unit 記録 (2015)
  • Author(s): 松尾健、國井尚人、斉藤延人、川合謙介
  • Organizer: 第38回日本てんかん外科学会
  • Place of Presentation: 東京
  • Year and Date: 2015-01-16
• [Presentation] てんかん外科：その進歩と今後の展開 (2014)
  • Author(s): 川合謙介
  • Organizer: 第73回日本脳神経外科学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-11
  • Invited
• [Presentation] Neuronal & neural networks in epilepsy – Surgical perspective (2014)
  • Author(s): Kawai, K. Matsuo, T. Kunii, N. Uno, T.
  • Organizer: 8th Asian Epilepsy Surgery Congress AESC 2014
  • Place of Presentation: Tokyo
  • Year and Date: 2014-10-05
  • Invited
• [Presentation] Cut it, leave it or shred it? (2014)
  • Author(s): 川合謙介、松尾健、國井尚人
  • Organizer: 第48回日本てんかん学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-03
  • Invited
• [Presentation] 側頭葉の解剖・機能・手術 (2014)
  • Author(s): 川合謙介
  • Organizer: 第4回 Epilepsy Expert Meeting
  • Place of Presentation: 名古屋
  • Year and Date: 2014-07-11
  • Invited
• [Patent(Industrial Property Rights)] 単一ニューロン活動と皮質脳波を同時記録する頭蓋内電極 (2015)
  • Inventor(s): 川合謙介
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-12-31