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Evaluation of physiological and pathological brain activities by simultaneous recording of single unit and intracranial EEG

Research Project

Project/Area Number 26462221
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionJichi Medical University (2015-2016)
Tokyo Health Care University (2014)

Principal Investigator

Kawai Kensuke  自治医科大学, 医学部, 教授 (70260924)

Co-Investigator(Kenkyū-buntansha) 國井 尚人  東京大学, 医学部附属病院, 助教 (80713940)
Co-Investigator(Renkei-kenkyūsha) MATSUO Takeshi  東京医療保健大学, 医学保健学部, 講師 (10733941)
Research Collaborator IBAYASHI Kenji  東京大学, 医学系研究科, 大学院生
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords単一ニューロン記録 / 頭蓋内脳波 / 頭蓋内電極 / ブレインマシンインターフェース / てんかん / single neuron recording / epilepsy / brain / human / electroencephalography / intracranial electrode / intracranial EEG / epilepsy surgery
Outline of Final Research Achievements

The present study is the first attempt in Japan to analyze physiological and pathological brain activities using custom-made electrodes for simultaneous recording of intracranial EEG and single neuron firing. The study clarified some aspects of thus-far undetected brain activities and suggested possibilities that those recording promote the understanding of physiological and pathological neural processes. Furthermore, it was expected that those recording improve localization of epileptogenic zones and outcome of surgical treatment of epilepsy, improve the quality of functional mapping, and furhter help developing BMI for treatment of brain diseases and support for disabled as implantable neuromodulation therapy in future.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (21 results)

All 2016 2015 2014 2013

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 3 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Long-term outcome and neuroradiologic changes after multiple hippocampal transection combined with multiple subpial transection or lesionectomy for temporal lobe epilepsy2016

    • Author(s)
      Usami K, Kubota M, Kawai K, Kunii N, Matsuo T, Ibayashi K, Takahashi M, Kamada K, Momose T, Aoki S, Saito N
    • Journal Title

      Epilepsia

      Volume: 57(6) Issue: 6 Pages: 931-940

    • DOI

      10.1111/epi.13374

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of vagus nerve stimulation on neural adaptation in thalamo-cortical system in rats2016

    • Author(s)
      Shiramatsu, T. I. Hitsuyu, R. Ibayashi, K. Kanzaki, R. Kawai, K. Takahashi, H.
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc

      Volume: 2016 Pages: 1834-1837

    • DOI

      10.1109/embc.2016.7591076

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Machine Learning of DTI Structural Brain Connectomes for Lateralization of Temporal Lobe Epilepsy2016

    • Author(s)
      Kamiya, K. Amemiya, S. Suzuki, Y. Kunii, N. Kawai, K. Mori, H. Kunimatsu, A. Saito, N. Aoki, S. Ohtomo, K.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 15 Issue: 1 Pages: 121-129

    • DOI

      10.2463/mrms.2015-0027

    • NAID

      130005118987

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epilepsy Surgery: Current Status and Ongoing Challenges2015

    • Author(s)
      Kawai K
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 55 Issue: 5 Pages: 357-366

    • DOI

      10.2176/nmc.ra.2014-0414

    • NAID

      130005069873

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Spontaneous Temporal Pole Encephalocele Presenting with Epilepsy: Report of Two Cases2015

    • Author(s)
      Shimada S, Kunii N, Kawai K, Usami K, Matsuo T, Uno T, Koizumi T, Saito N
    • Journal Title

      World Neurosurg

      Volume: 84 Issue: 3 Pages: 867.e1-867.e6

    • DOI

      10.1016/j.wneu.2015.04.028

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dissociated roles of the inferior frontal gyrus and superior temporal sulcus in audiovisual processing: Top-down and bottom-up mismatch detection2015

    • Author(s)
      Uno, T., Kawai, K., Sakai, K., Wakebe, T., Ibaraki, T., Kunii, N., Matsuo, T., & Saito, N.
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 3 Pages: e0122580-e0122580

    • DOI

      10.1371/journal.pone.0122580

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The significance of parahippocampal high gamma activity for memory preservation in surgical treatment of atypical temporal lobe epilepsy2014

    • Author(s)
      Kunii N,Kamada K(3番目)、他3名
    • Journal Title

      Epilepsia

      Volume: 55(10) Issue: 10 Pages: 1594-1601

    • DOI

      10.1111/epi.12764

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decoding visual object categories from temporal correlations of ECoG signals.2014

    • Author(s)
      Majima K, Matsuo T, Kawasaki K, Kawai K, Saito N, Hasegawa I, Kamitani Y.
    • Journal Title

      Neuroimage

      Volume: 90 Pages: 74-83

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alternating zones selective to faces and written words in the human ventral occipitotemporal cortex2013

    • Author(s)
      Matsuo T, Kawasaki K, Kawai K, Majima K, Masuda H, Murakami H, Kunii N, Kamitani Y, Kameyama S, Saito N, Hasegawa I
    • Journal Title

      Cereb Cortex

      Volume: (in press) Issue: 5 Pages: 1265-77

    • DOI

      10.1093/cercor/bht319

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 新型ハイブリッド型電極を用いたヒト顔面運動野の神経活動計測と平仮名調音のデコーディング2016

    • Author(s)
      井林賢志、國井尚人、松尾健、石下洋平、嶋田勢二郞、川合謙介、斉藤延人
    • Organizer
      第3回 脳神経外科BMI懇話会
    • Place of Presentation
      旭川医科大学研究棟1階小講堂 (北海道、旭川市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Decoding articulation by neuronal spike frequency and power spectrum recorded from human face motor cortex2016

    • Author(s)
      Ibayashi K, Matsuo T, Kunii N, Ishishita Y, Shimada S, Kawai K, Saito N
    • Organizer
      Human Single Unit Meeting
    • Place of Presentation
      Beckman Institute, California Institute of Technology (Pasadena, California, USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Decoding articulation by neuronal spike frequency and power spectrum recorded from human face motor cortex2016

    • Author(s)
      Ibayashi K, Matsuo T, Kunii N, Ishishita Y, Shimada S, Kawai K, Saito N
    • Organizer
      北米神経科学会
    • Place of Presentation
      San Diego Convention Center (San Diego, California, USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Decoding articulation of Japanese alphabet by unit firing pattern and power spectrum obtained from the human face motor cortex2016

    • Author(s)
      Ibayashi K, Matsuo T, Kunii N, Ishishita Y, Shimada S, Kawai K, Saito N
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜 (神奈川県、横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 単一ニューロン記録を用いた発声の復号化2015

    • Author(s)
      井林賢志、松尾健、國井尚人、川合謙介、斉藤延人
    • Organizer
      第2回脳神経BMI懇話会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-14
    • Related Report
      2015 Research-status Report
  • [Presentation] 海馬傍回高周波脳律動活動はTLE術後記銘力低下の予測因子となり得るか2015

    • Author(s)
      國井尚人,川合謙介,鎌田恭輔、太田貴裕、宇野健志、松尾健、斉藤延人
    • Organizer
      第17回日本ヒト脳機能マッピング学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
  • [Presentation] てんかん外科における次の一手ーsingle unit 記録2015

    • Author(s)
      松尾健、國井尚人、斉藤延人、川合謙介
    • Organizer
      第38回日本てんかん外科学会
    • Place of Presentation
      東京
    • Year and Date
      2015-01-16
    • Related Report
      2014 Research-status Report
  • [Presentation] てんかん外科:その進歩と今後の展開2014

    • Author(s)
      川合謙介
    • Organizer
      第73回日本脳神経外科学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-11
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Neuronal & neural networks in epilepsy – Surgical perspective2014

    • Author(s)
      Kawai, K. Matsuo, T. Kunii, N. Uno, T.
    • Organizer
      8th Asian Epilepsy Surgery Congress AESC 2014
    • Place of Presentation
      Tokyo
    • Year and Date
      2014-10-05
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Cut it, leave it or shred it?2014

    • Author(s)
      川合謙介、松尾健、國井尚人
    • Organizer
      第48回日本てんかん学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-03
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 側頭葉の解剖・機能・手術2014

    • Author(s)
      川合謙介
    • Organizer
      第4回 Epilepsy Expert Meeting
    • Place of Presentation
      名古屋
    • Year and Date
      2014-07-11
    • Related Report
      2014 Research-status Report
    • Invited
  • [Patent(Industrial Property Rights)] 単一ニューロン活動と皮質脳波を同時記録する頭蓋内電極2015

    • Inventor(s)
      川合謙介
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-12-31
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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