• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Overcome of intractable radiation necrosis. Bevacizumab therapy and beyond bevacizumab

Research Project

Project/Area Number 26462222
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionOsaka Medical College

Principal Investigator

Furuse Motomasa  大阪医科大学, 医学部, 講師 (70340560)

Co-Investigator(Kenkyū-buntansha) 川端 信司  大阪医科大学, 医学部, 講師 (20340549)
Research Collaborator NONOGUCHI Naosuke  
TOHO Taichiro  
TSUJI Yuichiro  
FUKUMURA Masao  
YOSHIKAWA Masashi  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords放射線壊死 / ベバシズマブ / 神経膠腫 / 髄膜腫 / VEGF / bevacizumab / glioma / glioblastoma / radiation / radiation necrosis / meningioma
Outline of Final Research Achievements

The aim of this study was to concur radiation necrosis of the brain. In a laboratory study, an optical radiation dose for formation of radiation necrosis was clarified in rats. Radiation necrosis stably appeared 6 months after 65 Gy of a single fraction. In the next study, key molecules for radiation necrosis will be elucidated using this model. In a clinical study, bevacizumab suppressed radiation necrosis, but not tumor tissue in previously irradiated meningioma. Recurrent meningioma could be distinguished from radiation necrosis by administration of bevacizumab. In radiation necrosis, efficacy of bevacizumab lasted 6 months after completion of bevacizumab therapy. And we reported pathological review of brain radiation necrosis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (24 results)

All 2017 2016 2015 2014

All Journal Article (10 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 3 results,  Open Access: 5 results) Presentation (14 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Immunotherapy of Nivolumab with Dendritic Cell Vaccination Is Effective against Intractable Recurrent Primary Central Nervous System Lymphoma: A Case Report2017

    • Author(s)
      Furuse M, Nonoguchi N, Naoki O, Shirahata M, Iwasaki K, Inui T, Kuroiwa T, Kuwabara H, Miyatake SI
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 57 Issue: 4 Pages: 191-197

    • DOI

      10.2176/nmc.cr.2016-0330

    • NAID

      130006882497

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Delayed brain radiation necrosis: Pathological review and new molecular targets for treatment.2015

    • Author(s)
      Furuse M, Nonoguchi N, Kawabata S, Miyatake SI, Kuroiwa T
    • Journal Title

      Med Mol Morphol

      Volume: 48 Pages: 183-190

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Intratumoral and peritumoral post-irradiation changes, but not viable tumor.2015

    • Author(s)
      Furuse M, Nonoguchi N, Kawabata S, Miyata T, Toho T, Kuroiwa T, Miyatake S.
    • Journal Title

      Radiat Oncol.

      Volume: 10 Issue: 1 Pages: 156-156

    • DOI

      10.1186/s13014-015-0446-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathophysiology, Diagnosis, and Treatment of Radiation Necrosis in the Brain2015

    • Author(s)
      Shin-Ichi Miyatake, Noasuke Nonoguchi, Motomasa Furuse, Erina Yoritsune, Tomo Miyata, Shinji Kawabata, and Toshihiko Kuroiwa
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 55 Issue: 1 Pages: 50-59

    • DOI

      10.2176/nmc.ra.2014-0188

    • NAID

      130004922267

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脳放射線壊死とミクログリア2015

    • Author(s)
      野々口 直助、古瀬 元雅、宮武 伸一
    • Journal Title

      Clinical Neuroscience

      Volume: 33 Pages: 1377-1381

    • Related Report
      2015 Research-status Report
  • [Journal Article] 進行性放射線壊死に対するベバシズマブ治療 自験例および臨床試験の経過報告2014

    • Author(s)
      古瀬 元雅、川端 信司、黒岩 敏彦、宮武 伸一
    • Journal Title

      定位放射線治療

      Volume: 18 Pages: 147-152

    • Related Report
      2014 Research-status Report
  • [Journal Article] Boron neutron capture therapy with bevacizumab may prolong the survival of recurrent malignant glioma patients: four cases2014

    • Author(s)
      Miyatake SI, Kawabata S, Hiramatsu R, Furuse M, Kuroiwa T, Suzuki M.
    • Journal Title

      Radiation Oncology

      Volume: 9 Issue: 1 Pages: 6-11

    • DOI

      10.1186/1748-717x-9-6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The roles of platelet-derived growth factors and their receptors in brain radiation necrosis2014

    • Author(s)
      Miyata T, Toho T, Nonoguchi N, Furuse M, Kuwabara H, Yoritsune E, Kawabata S, Kuroiwa T, and Miyatake S
    • Journal Title

      Radiation Oncology

      Volume: 9 Issue: 1 Pages: 51-59

    • DOI

      10.1186/1748-717x-9-51

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inflammation as well as angiogenesis may participate in the pathophysiology of brain radiation necrosis.2014

    • Author(s)
      Yoritsune E, Furuse M, Kuwabara H, Miyata T, Nonoguchi N, Kawabata S, Hana Hayasaki H, Kuroiwa T, Ono K, Shibayama Y, and Miyatake S
    • Journal Title

      J Radiat Res

      Volume: 55(4) Issue: 4 Pages: 803-11

    • DOI

      10.1093/jrr/rru017

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] V XIII 脳放射線壊死の成因、診断、治療2014

    • Author(s)
      宮武 伸一、古瀬 元雅、野々口 直助、黒岩 敏彦
    • Journal Title

      別冊日本臨床 神経症候群(第2版)-その他の神経疾患を含めて- III

      Volume: 第2版 Pages: 873-876

    • Related Report
      2014 Research-status Report
  • [Presentation] PS不良再発神経膠芽腫におけるベバシズマブの治療効果2016

    • Author(s)
      古瀬 元雅、川端 信司、池田 直廉、野々口 直助、田村 陽史、梶本 宜永、宮武 伸一、黒岩 敏彦
    • Organizer
      第34回日本脳腫瘍学会学術集会
    • Place of Presentation
      甲府富士屋ホテル
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] Treatment efficacy of bevacizumab on malignant glioma in patients with poor performance status2016

    • Author(s)
      Furuse M, Hiramatsu R, Kawabata S, Kuroiwa T
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] PS不良再発神経膠芽腫におけるベバシズマブの治療効果2016

    • Author(s)
      古瀬 元雅、池田 直廉、野々口 直助、川端 信司、田村 陽史、梶本 宜永、宮武 伸一、黒岩 敏彦
    • Organizer
      日本脳神経外科学会 第75回学術総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] Bevacizumab for brain radiation necrosis2016

    • Author(s)
      Furuse M, Ikeda N, Nonoguchi N, Kawabata S, Miyatake SI, Kuroiwa T
    • Organizer
      13th Asian Society for Neuro-Oncology meeting
    • Place of Presentation
      Sheraton on the park Sydney
    • Year and Date
      2016-09-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 症候性脳放射線壊死に対するベバシズマブ治療 多施設共同前向き臨床試験2015

    • Author(s)
      古瀬 元雅、野々口 直助、黒岩 敏彦、中谷 英仁、栗栖 晶子、中川 陽子、宮武 伸一
    • Organizer
      第33回日本脳腫瘍学会学術集会
    • Place of Presentation
      グランドプリンスホテル京都
    • Year and Date
      2015-12-06
    • Related Report
      2015 Research-status Report
  • [Presentation] A prospective multicenter single-arm clinical trial of bevacizumab for patients with surgically untreatable symptomatic brain radiation necrosis2015

    • Author(s)
      Furuse M, Nonoguchi N, Kuroiwa T, Nakatani E, Kurisu S, Nakagawa Y, Miyatake SI
    • Organizer
      20th Annual Scientific Meeting of the Society for Neuro-Oncology
    • Place of Presentation
      Marriott Rivercenter, San Antonio
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 遅発性脳放射線壊死に対するベバシズマブ治療 多施設共同臨床試験のサブ解析2015

    • Author(s)
      古瀬 元雅、野々口 直助、黒岩 敏彦、中谷 英仁、栗栖 晶子、中川 陽子、宮武 伸一
    • Organizer
      日本脳神経外科学会 第74回学術総会
    • Place of Presentation
      ロイトン札幌
    • Year and Date
      2015-10-14
    • Related Report
      2015 Research-status Report
  • [Presentation] Multicenter clinical trial of bevacizumab for patients with surgically untreatable symptomatic brain radiation necrosis2015

    • Author(s)
      Furuse M, Nonoguchi N, Kawabata S, Miyatake SI, Kuroiwa T
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 再発髄膜腫に対する放射線治療とbevacizumabの役割2015

    • Author(s)
      古瀬 元雅、野々口 直助、川端 信司、宮武 伸一,黒岩 敏彦
    • Organizer
      第20回日本脳腫瘍の外科学会
    • Place of Presentation
      名古屋観光ホテル
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report
  • [Presentation] Efficacy of bevacizumab on radiation necrosis diagnosed by PET2015

    • Author(s)
      Furuse M, Nonoguchi N, Kawabata S, Kuroiwa T, Miyatake SI
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      Kyoto International Conference Center
    • Year and Date
      2015-05-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ベバシズマブは髄膜腫には有効か?2014

    • Author(s)
      古瀬 元雅、野々口 直助、川端 信司、黒岩 敏彦、宮武 伸一
    • Organizer
      第32回日本脳腫瘍学会学術集会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル(千葉県・浦安市)
    • Year and Date
      2014-11-30 – 2014-12-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 悪性神経膠腫に対するベバシズマブ治療 自験例の検討2014

    • Author(s)
      古瀬 元雅、野々口 直助、川端 信司、田村 陽史、梶本 宜永、宮武 伸一、黒岩 敏彦
    • Organizer
      日本脳神経外科学会 第73回学術総会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都・港区)
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Bevacizumab for malignant glioma. A single-institution experience2014

    • Author(s)
      Motomasa Furuse, Shinji Kawabata, Shin-Ichi Miyatake, Toshihiko Kuroiwa
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 放射線壊死 -診断と治療-2014

    • Author(s)
      古瀬 元雅
    • Organizer
      第27回関西脳神経外科セミナー
    • Place of Presentation
      新阪急ホテル(大阪府・大阪市)
    • Year and Date
      2014-07-04
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi