Investigation of biomarkers for responders in vagus nerve stimulation therapy
| Project/Area Number |
26462223
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | Kindai University |
|---|
Principal Investigator |
KATO Amami 近畿大学, 医学部, 教授 (00233776)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
池田 昭夫 京都大学, 医学研究科, 特定教授 (90212761)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NAKANO Naoki 近畿大学, 医学部, 講師 (60258027)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 難治てんかん / 迷走神経刺激療法 / バイオマーカ / バイオマーカー |
|---|
| Outline of Final Research Achievements |
Vagus nerve stimulation therapy (VNS) is a palliative treatment option for patients with intractable epilepsy who are not good candidates for surgical resection. The biomarker for responder to VNS is, however, not well known. We investigated the clinical features of VNS responders after starting stimulation. We also analyzed routine clinical electroencephalograms (EEGs) from 24 patients who were undergoing seizure treatment by VNS. We compared SCPs at 5 electrodes (around Cz) between the 2 states of VNS: stimulation period and inter-stimulation period. As the results, a positive shift of SCP correlated significantly with seizure reduction, and could be a surrogate marker for VNS response.
|
Report
(4 results)
Research Products
(45 results)
-
[Journal Article] Navigation-assisted trans-inferotemporal cortex selective amygdalohippocampectomy for mesial temporal lobe epilepsy; preserving the temporal stem.2017
Author(s)
Kishima H, Kato A, Oshino S, Tani N, Maruo T, Khoo HM, Yanagisawa T, Edakawa K, Kobayashi M, Tanaka M, Hosomi K, Hirata M1, Yoshimine T
-
Journal Title
Neurol Res
Volume: 39(3)
Issue: 3
Pages: 223-230
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
[Journal Article] Electrical stimulation of the parahippocampal gyrus for prediction of posthippocampectomy verbal memory decline2016
Author(s)
Tani N, Kishima H, Khoo HM, Yanagisawa T, Oshino S, Maruo T, Hosomi K, Hirata M, Kazui H, Nomura KT, Aly MM, Kato A, Yoshimine T
-
Journal Title
J Neurosurg.
Volume: 15
Issue: 5
Pages: 1-8
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 当院の脳梁離断術手術手技2017
Author(s)
中野直樹, 宮内正晴, 吉岡宏真, 村上沙織, 田崎貴之, 岩倉倫裕, 加藤天美
Organizer
第40回日本てんかん外科学会
Place of Presentation
コングレコンベンションセンター（大阪市）
Year and Date
2017-01-26
Related Report
-
-
-
-
-
-
-
-
-
-
[Presentation] てんかん とは何か2015
Author(s)
加藤天美
Organizer
てんかん月間メディアセミナー
Place of Presentation
東京（エムワイ貸会議室高田馬場）
Year and Date
2015-10-16
Related Report
Invited
-
-
-
-
-
-
-
