| Project/Area Number |
26462223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kindai University |
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Principal Investigator |
KATO Amami 近畿大学, 医学部, 教授 (00233776)
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| Co-Investigator(Kenkyū-buntansha) |
池田 昭夫 京都大学, 医学研究科, 特定教授 (90212761)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKANO Naoki 近畿大学, 医学部, 講師 (60258027)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 難治てんかん / 迷走神経刺激療法 / バイオマーカ / バイオマーカー |
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| Outline of Final Research Achievements |
Vagus nerve stimulation therapy (VNS) is a palliative treatment option for patients with intractable epilepsy who are not good candidates for surgical resection. The biomarker for responder to VNS is, however, not well known. We investigated the clinical features of VNS responders after starting stimulation. We also analyzed routine clinical electroencephalograms (EEGs) from 24 patients who were undergoing seizure treatment by VNS. We compared SCPs at 5 electrodes (around Cz) between the 2 states of VNS: stimulation period and inter-stimulation period. As the results, a positive shift of SCP correlated significantly with seizure reduction, and could be a surrogate marker for VNS response.
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