| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Effect of hyaluronic acid (HA) for osteoarthritis is still controversial. We examined the histopathological changes and the friction coefficient in osteoarthritic knee joint after different molecular weight HA injection (low molecular weight HA, 0.8x106 Da or Ultra-high molecular weight, 6x106 Da) using a rabbit osteoarthritis model. Macroscopic findings showed that severe damaged cartilage was observed in 10% of Ultra-high molecular weight HA and 30% of low molecular weight HA and NS. The histological score and the friction coefficient value of Ultra-high molecular weight HA group were significantly lower than those of the control group (P < 0.05). Ultra-high molecular weight HA has potential chondroprotective effects and superior fiction coefficient. These factors would contribute to prevent progression of osteoarthritis. Intrajoint alteration of molecular weight HA should be clarified in future study.
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