Effects of Radiation on Spinal Dura Mater and Surrounding Tissue in Mice
Project/Area Number |
26462233
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
|
Research Institution | Kanazawa University |
Principal Investigator |
|
Research Collaborator |
YOKOGAWA Noriaki 金沢大学, 医学系, 大学院生
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 放射線障害 / 硬膜外fibrosis / 硬膜損傷 / 髄液漏 / 放射線傷害 / 髄膜透過性亢進 / 術後髄液漏 |
Outline of Final Research Achievements |
This study confirms that epidural fibrosis is induced in the late stages after high-dose irradiation in mice, and that overexpression of TGF-β1 occurs in a manner similar to radiation-induced fibrosis in other tissue. Additionally, thinning of the ABC was observed in the late stages after irradiation. Thus, consideration should be given to the possibility that these phenomena can occur as radiation-induced injuries of the spine.
|
Report
(4 results)
Research Products
(7 results)
-
-
-
-
-
-
[Presentation] 放射線照射が硬膜とその周囲組織に与える影響2015
Author(s)
横川文彬,村上英樹,出村諭,加藤仁志,吉岡克人,土屋弘行
Organizer
第124回中部日本整形外科災害外科学会(金沢) 4月10-11日
Place of Presentation
金沢、ホテル日航金沢・ANAクラウンプラザホテル金沢
Year and Date
2015-04-10
Related Report
-