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The mechanism to rescue the inflammation of injured spinal cord tissue especially for the influence of leptin.

Research Project

Project/Area Number 26462244
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionNagoya City University

Principal Investigator

SAKUMA Eisuke  名古屋市立大学, 大学院医学研究科, 講師 (90295585)

Co-Investigator(Kenkyū-buntansha) 和田 郁雄  名古屋市立大学, 大学院医学研究科, 教授 (70182970)
若林 健二郎  名古屋市立大学, 大学院医学研究科, 助教 (20418867)
伊藤 錦哉  名古屋市立大学, 大学院医学研究科, 研究員 (50597820)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords再生医療 / ミクログリア / 下垂体前葉 / 脊髄損傷 / 炎症 / 下垂体 / 移植 / 濾胞星細胞 / ギャップジャンクション / レプチン / ズッカーラット
Outline of Final Research Achievements

In the acute spinal injury, we must try to minimize the inflammation of the spinal cord tissue. We try to rescue this inflammation and investigate the mechanism to suppress the microglia for minimizing the inflammation. The ghrelin system activated by Rikkunshito significantly reduced the number of pathologically activated microglia with amoeboid morphology in the brains of klotho-deficient, SAMP8 and aged ICR mice. We also report that SGK1 and SGK3 are expressed in multiple microglial cell lines. An SGK inhibitor, gsk650394, inhibits cell viability. In addition, lipopolysaccharide-induced expression of inflammatory regulators iNOS and TNFa was enhanced by gsk650394. These findings suggest that SGKs may play an important role in regulating microglial viability and inflammatory responses. These two investigations include the important findings to rescue this inflammation of the spinal cord tissue.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (2 results)

  • [Journal Article] Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1.2016

    • Author(s)
      Fujitsuka N, Asakawa A, Morinaga A, Amitani MS, Amitani H, Katsuura G, Sawada Y, Sudo Y, Uezono Y, Mochiki E, Sakata I, Sakai T, Hanazaki K, Yada T, Yakabi K, Sakuma E, Ueki T, Niijima A, Nakagawa K, Okubo N, Takeda H, Asaka M, Inui A.
    • Journal Title

      Mol Psychiatry

      Volume: 21 Issue: 11 Pages: 1-11

    • DOI

      10.1038/mp.2015.220

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum- and glucocorticoid-inducible kinases in microglia.2016

    • Author(s)
      Inoue K, Sakuma E, Morimoto H, Asai H, Koide Y, Leng T, Wada I, Xiong ZG, Ueki T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 478 Issue: 1 Pages: 53-59

    • DOI

      10.1016/j.bbrc.2016.07.094

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The changes of gap junctions between pituitary folliculo-stellate cells during the postnatal development of Zucker fatty and lean rats2014

    • Author(s)
      Sakuma E, Wada I, Soji T, Wakabayashi K, Otsuka T, Herbert DC.
    • Journal Title

      Microsc Res Tech

      Volume: 77 Pages: 31-36

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intercellular communications within the rat anterior pituitary. XVI: postnatal changes of distribution of S-100 protein positive cells, connexin 43 and LH-RH positive sites in the pars tuberalis of the rat pituitary gland. An immunohistochemical and electron microscopic study2014

    • Author(s)
      Wada I, Sakuma E, Shirasawa N, Wakabayashi K, Otsuka T, Hattori K, Yashiro T, Herbert DC, Soji T.
    • Journal Title

      Tissue Cell

      Volume: 46 Pages: 33-39

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] リン酸化酵素SGKによるミクログリア活性の調節2016

    • Author(s)
      井上浩一、佐久間英輔、森本浩之、和田郁雄、植木孝俊
    • Organizer
      第121回日本解剖学会総会全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Postnatal Changes of Distribution of S-100 Protein Positive Cells, Connexin 43 and LH-RH Positive Sites in the Pars Tuberalis of the Rat Pituitary Gland2015

    • Author(s)
      Sakuma E, Wada I, Shirasawa N, Wakabayashi K, Otsuka T, Ueki T
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会 合同大会
    • Place of Presentation
      神戸国際会議場(神戸市・兵庫県)
    • Year and Date
      2015-03-22
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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